PMID- 29515003
OWN - NLM
STAT- MEDLINE
DCOM- 20191011
LR  - 20221207
IS  - 1872-9061 (Electronic)
IS  - 0300-2977 (Linking)
VI  - 76
IP  - 2
DP  - 2018 Mar
TI  - Type 2 diabetes mellitus severity correlates with risk of hip fracture in 
      patients with osteoporosis.
PG  - 65-71
AB  - BACKGROUND: Osteoporosis is a major public health problem because of its 
      associated fractures and the resulting complications. The objective of this study 
      was to identify the association between the severity of type 2 diabetes mellitus 
      (T2DM) and the risk of hip fracture in osteoporotic patients. METHODS: The 
      patients who received a diagnosis of osteoporosis between 2006 and 2010, with an 
      adequate follow-up between 2006 and 2015, were enrolled in this study. Among 
      patients with T2DM, the severity of the disease was evaluated using the Diabetes 
      Complication Severity Index (DCSI). Logistic regression models were used to 
      calculate the odds ratios and to predict the risk of hip fracture in diabetic 
      osteoporotic patients. RESULTS: A total of 1188 patients were enrolled in the 
      final study, 87 patients had hip fractures in the follow-up period between 2006 
      and 2015. Among the diabetic patients, each level of the continuous DCSI was 
      associated with a 1.56-fold greater risk of hip fracture. In further 
      stratification, patients with a DCSI > 3 had a significantly higher risk of hip 
      fracture in comparison with those with a DCSI </= 1. The categorical DCSI (DCSI > 
      3), HbA1c level on the diagnosis of T2DM and duration of diabetes, facilitate 
      predicting the risk of hip fracture. CONCLUSION: The severity of T2DM reflects 
      the risk of hip fracture in osteoporotic patients. Physicians should pay 
      attention to osteoporotic patients presenting with a high HbA1c level on 
      diagnosis of T2DM and a higher DCSI because of their vulnerability to hip 
      fracture.
FAU - Hsu, J-Y
AU  - Hsu JY
AD  - Department of Orthopedics, National Taiwan University Hospital, Taipei, Taiwan.
FAU - Cheng, C-Y
AU  - Cheng CY
FAU - Hsu, C-Y
AU  - Hsu CY
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Neth J Med
JT  - The Netherlands journal of medicine
JID - 0356133
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (hemoglobin A1c protein, human)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Comorbidity
MH  - Diabetes Complications/blood/*epidemiology
MH  - Diabetes Mellitus, Type 2/blood/diagnosis/*epidemiology
MH  - Female
MH  - Glycated Hemoglobin/metabolism
MH  - Hip Fractures/*etiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Osteoporosis/*complications/*epidemiology
MH  - Prevalence
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Severity of Illness Index
MH  - Taiwan/epidemiology
EDAT- 2018/03/09 06:00
MHDA- 2019/10/12 06:00
CRDT- 2018/03/09 06:00
PHST- 2018/03/09 06:00 [entrez]
PHST- 2018/03/09 06:00 [pubmed]
PHST- 2019/10/12 06:00 [medline]
PST - ppublish
SO  - Neth J Med. 2018 Mar;76(2):65-71.