PMID- 29516164
OWN - NLM
STAT- MEDLINE
DCOM- 20180724
LR  - 20181114
IS  - 1432-2307 (Electronic)
IS  - 0945-6317 (Linking)
VI  - 473
IP  - 1
DP  - 2018 Jul
TI  - Cathepsin K expression in clear cell "sugar" tumor (PEComa) of the lung.
PG  - 55-59
LID - 10.1007/s00428-018-2325-1 [doi]
AB  - Clear cell "sugar" tumor is a rare benign neoplasm arising in the lung, 
      considered as a part of the PEComa family. As PEComas of other sites, this tumor 
      expresses melanocytic markers such as HMB45 and Melan-A. Despite cathepsin K, 
      MITF and CD68 staining are known to be positive in a large number of PEComas and 
      TFE3 rearrangement has been reported in a subset of PEComas, no data is available 
      regarding the expression of these markers and the occurrence of TFE3 and TFEB 
      rearrangement in clear cell "sugar" tumor of the lung. We have investigated the 
      immunolabeling of cathepsin K, MITF, and CD68 in five cases of clear cell "sugar" 
      tumor. Moreover, we have also sought the presence of TFE3 and TFEB rearrangement 
      by fluorescence in situ hybridization (FISH) assay. In all tumors, strong 
      immunoreactivity of cathepsin K and CD68 (PG-M1 and KP1 clone) was demonstrated, 
      whereas none of them labeled for MITF staining and showed TFE3 or TFEB 
      rearrangement. These findings widen the immunohistochemical profile of clear cell 
      "sugar" tumor providing useful new markers for challenging cases. The expression 
      of lysosomal markers, such as cathepsin K and CD68, strengthens the hypothesis 
      that this tumor is part of the PEComa family.
FAU - Calio, Anna
AU  - Calio A
AD  - Department of Diagnostic and Public Health, Section of Pathology, University of 
      Verona, Largo L. Scuro 10, 37134, Verona, Italy.
FAU - Mengoli, Maria Cecilia
AU  - Mengoli MC
AD  - Department of Pathology, Arcispedale S. Maria Nuova/I.R.C.C.S., Reggio Emilia, 
      Italy.
FAU - Cavazza, Alberto
AU  - Cavazza A
AD  - Department of Pathology, Arcispedale S. Maria Nuova/I.R.C.C.S., Reggio Emilia, 
      Italy.
FAU - Rossi, Giulio
AU  - Rossi G
AD  - Operative Unit of Pathologic Anatomy, Hospital S. Maria delle Croci, Azienda 
      Romagna, Ravenna, Italy.
FAU - Ghimenton, Claudio
AU  - Ghimenton C
AD  - Department of Diagnostic and Public Health, Section of Pathology, University of 
      Verona, Largo L. Scuro 10, 37134, Verona, Italy.
FAU - Brunelli, Matteo
AU  - Brunelli M
AD  - Department of Diagnostic and Public Health, Section of Pathology, University of 
      Verona, Largo L. Scuro 10, 37134, Verona, Italy.
FAU - Pea, Maurizio
AU  - Pea M
AD  - Department of Pathology, Orlandi Hospital, Bussolengo, Verona, Italy.
FAU - Chilosi, Marco
AU  - Chilosi M
AD  - Department of Pathology, Pederzoli Hospital, Peschiera del Garda, Italy.
FAU - Marcolini, Lisa
AU  - Marcolini L
AD  - Department of Pathology, Pederzoli Hospital, Peschiera del Garda, Italy.
FAU - Martignoni, Guido
AU  - Martignoni G
AD  - Department of Diagnostic and Public Health, Section of Pathology, University of 
      Verona, Largo L. Scuro 10, 37134, Verona, Italy. guido.martignoni@univr.it.
AD  - Department of Pathology, Pederzoli Hospital, Peschiera del Garda, Italy. 
      guido.martignoni@univr.it.
LA  - eng
PT  - Journal Article
DEP - 20180307
PL  - Germany
TA  - Virchows Arch
JT  - Virchows Archiv : an international journal of pathology
JID - 9423843
RN  - 0 (Antigens, CD)
RN  - 0 (Antigens, Differentiation, Myelomonocytic)
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (CD68 antigen, human)
RN  - EC 3.4.22.38 (Cathepsin K)
SB  - IM
MH  - Adult
MH  - Antigens, CD/metabolism
MH  - Antigens, Differentiation, Myelomonocytic/metabolism
MH  - Biomarkers, Tumor/*metabolism
MH  - Cathepsin K/*metabolism
MH  - Female
MH  - Gene Rearrangement/genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence/methods
MH  - Kidney Neoplasms/metabolism/*pathology
MH  - Lung/metabolism/pathology
MH  - Male
MH  - Middle Aged
MH  - Perivascular Epithelioid Cell Neoplasms/diagnosis/genetics/*pathology
MH  - Translocation, Genetic/genetics
OTO - NOTNLM
OT  - Cathepsin K
OT  - Clear cell "sugar" tumor
OT  - Immunohistochemistry
OT  - PEComa
EDAT- 2018/03/09 06:00
MHDA- 2018/07/25 06:00
CRDT- 2018/03/09 06:00
PHST- 2018/01/11 00:00 [received]
PHST- 2018/02/16 00:00 [accepted]
PHST- 2018/02/15 00:00 [revised]
PHST- 2018/03/09 06:00 [pubmed]
PHST- 2018/07/25 06:00 [medline]
PHST- 2018/03/09 06:00 [entrez]
AID - 10.1007/s00428-018-2325-1 [pii]
AID - 10.1007/s00428-018-2325-1 [doi]
PST - ppublish
SO  - Virchows Arch. 2018 Jul;473(1):55-59. doi: 10.1007/s00428-018-2325-1. Epub 2018 
      Mar 7.