PMID- 29516260
OWN - NLM
STAT- MEDLINE
DCOM- 20181001
LR  - 20211129
IS  - 1567-2387 (Electronic)
IS  - 1567-2379 (Linking)
VI  - 49
IP  - 3
DP  - 2018 Jun
TI  - Activation of satellite glial cells in trigeminal ganglion following dental 
      injury and inflammation.
PG  - 257-263
LID - 10.1007/s10735-018-9765-4 [doi]
AB  - Satellite glial cells (SGCs), a peripheral neuroglial cell, surround neurons and 
      form a complete envelope around individual sensory neurons in the trigeminal 
      ganglia (TG), which may be involved in modulating neurons in inflammation. The 
      purpose of this study was to determine the effect of dental injury and 
      inflammation on SGCs in the TG. Pulp exposure (PX) was performed on the first 
      maxillary molar of 28 rats. The neurons innervating injured tooth in TG were 
      labeled by the retrograde transport of fluoro-gold (FG). Specimens were collected 
      at 1, 3, 7, 14, 21 and 28 days after PX and stained immunohistochemically for 
      glial fibrillary acid protein (GFAP), a marker of SGCs activation, in the TG. We 
      observed that GFAP-immunoreactivity (IR) SGCs enclosed FG-labeled neurons 
      increased in a time-dependent manner after PX. The neurons surrounded by GFAP-IR 
      SGCs were mainly small and medium in size. The GFAP-IR SGCs encircled neurons 
      increased significantly in the maxillary nerve region of the TG at 7-28 days 
      following PX. The results show that dental injury and inflammation induced SGCs 
      activation in the TG. It indicates that activation of SGCs might be implicated in 
      the peripheral mechanisms of pain following dental injury and inflammation.
FAU - Liu, Haichao
AU  - Liu H
AD  - Guangdong Provincial Key Laboratory of Stomatology, Guanghua School of 
      Stomatology, Sun Yat-sen University, Guangzhou, 510080, China.
FAU - Zhao, Lei
AU  - Zhao L
AD  - Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key 
      Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer 
      Medicine, Guangzhou, 510060, China.
FAU - Gu, Wenzhen
AU  - Gu W
AD  - Guangdong Provincial Key Laboratory of Stomatology, Guanghua School of 
      Stomatology, Sun Yat-sen University, Guangzhou, 510080, China.
FAU - Liu, Qin
AU  - Liu Q
AD  - Guangdong Provincial Key Laboratory of Stomatology, Guanghua School of 
      Stomatology, Sun Yat-sen University, Guangzhou, 510080, China.
FAU - Gao, Zhixiong
AU  - Gao Z
AD  - Guangdong Provincial Key Laboratory of Stomatology, Guanghua School of 
      Stomatology, Sun Yat-sen University, Guangzhou, 510080, China.
FAU - Zhu, Xiao
AU  - Zhu X
AD  - Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Guangdong 
      Medical University, Dongguan, 523808, China.
FAU - Wu, Zhi
AU  - Wu Z
AD  - Guangdong Provincial Key Laboratory of Stomatology, Guanghua School of 
      Stomatology, Sun Yat-sen University, Guangzhou, 510080, China.
FAU - He, Hongwen
AU  - He H
AD  - Guangdong Provincial Key Laboratory of Stomatology, Guanghua School of 
      Stomatology, Sun Yat-sen University, Guangzhou, 510080, China.
FAU - Huang, Fang
AU  - Huang F
AD  - Guangdong Provincial Key Laboratory of Stomatology, Guanghua School of 
      Stomatology, Sun Yat-sen University, Guangzhou, 510080, China. 
      hfang@mail.sysu.edu.cn.
FAU - Fan, Wenguo
AU  - Fan W
AD  - Guangdong Provincial Key Laboratory of Stomatology, Guanghua School of 
      Stomatology, Sun Yat-sen University, Guangzhou, 510080, China. 
      fanweng@mail.sysu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20180308
PL  - Netherlands
TA  - J Mol Histol
JT  - Journal of molecular histology
JID - 101193653
RN  - 0 (Glial Fibrillary Acidic Protein)
SB  - IM
MH  - Animals
MH  - Glial Fibrillary Acidic Protein/analysis
MH  - Inflammation/*etiology
MH  - Maxillary Nerve/cytology
MH  - Neuroglia/*metabolism
MH  - Neurons/metabolism
MH  - Pain/etiology
MH  - Rats
MH  - Satellite Cells, Perineuronal/*metabolism
MH  - Time Factors
MH  - Tooth Injuries/*pathology
MH  - Trigeminal Ganglion/*cytology
OTO - NOTNLM
OT  - Dental inflammation
OT  - Fluoro-gold
OT  - Glial fibrillary acidic protein (GFAP)
OT  - Immunohistochemistry
OT  - Satellite glial cells
EDAT- 2018/03/09 06:00
MHDA- 2018/10/03 06:00
CRDT- 2018/03/09 06:00
PHST- 2017/12/25 00:00 [received]
PHST- 2018/02/26 00:00 [accepted]
PHST- 2018/03/09 06:00 [pubmed]
PHST- 2018/10/03 06:00 [medline]
PHST- 2018/03/09 06:00 [entrez]
AID - 10.1007/s10735-018-9765-4 [pii]
AID - 10.1007/s10735-018-9765-4 [doi]
PST - ppublish
SO  - J Mol Histol. 2018 Jun;49(3):257-263. doi: 10.1007/s10735-018-9765-4. Epub 2018 
      Mar 8.