PMID- 29516593
OWN - NLM
STAT- MEDLINE
DCOM- 20190510
LR  - 20190510
IS  - 1399-5618 (Electronic)
IS  - 1398-5647 (Linking)
VI  - 20
IP  - 8
DP  - 2018 Dec
TI  - Lower levels of brain-derived neurotrophic factor are associated with melancholic 
      psychomotor retardation among depressed inpatients.
PG  - 746-752
LID - 10.1111/bdi.12636 [doi]
AB  - OBJECTIVES: Melancholic depression is a type of depression which is closely 
      related to biological variables than are other types of depression. Its clinical 
      features can be assessed using six items on the Hamilton Depression Rating Scale 
      (HAM-D(6) ). Previous studies have shown, using item response theory, that the 
      symptom depressed mood is the least severe melancholic feature; work and 
      activities, somatic symptoms and psychic anxiety are of moderate severity; and 
      feelings of guilt and psychomotor retardation are the most severe. We aimed to 
      evaluate whether the more severe melancholic signs or symptoms were associated 
      with decreases in brain-derived neurotrophic factor (BDNF) levels. METHODS: A 
      total of 151 severely depressed inpatients had their BDNF levels analyzed by 
      comparing those who presented with each HAM-D(6) melancholic feature to those for 
      whom the HAM-D(6) feature was absent, using multiple linear regressions. The 
      levels of BDNF of patients who presented with each melancholic feature were also 
      compared with those of 100 healthy controls. RESULTS: Depressed patients' median 
      BDNF level was 44.06 ng/mL (interquartile range [IQR]: 33.99-62.4 ng/mL), and 
      controls' median BDNF level was 65.22 ng/mL (IQR: 49.87-76.08 ng/mL) (P < .001). 
      The presence of depressed mood, work and activities, somatic symptoms, psychic 
      anxiety, and guilty feelings was not associated with BDNF levels. However, the 
      presence of psychomotor retardation was associated with reduced BDNF (median 
      reduction -10.07 ng/mL; 95% confidence interval [CI]: -19.43 to -0.71; P = .03). 
      CONCLUSIONS: To the best of our knowledge, this study is the first to associate 
      BDNF levels with melancholic features in a sample of severely depressed 
      inpatients. The main finding of this study was that severely depressed inpatients 
      who presented the most severe melancholic feature, psychomotor retardation, had 
      significantly reduced BDNF levels in the blood.
CI  - (c) 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Primo de Carvalho Alves, Lucas
AU  - Primo de Carvalho Alves L
AUID- ORCID: 0000-0003-4387-224X
AD  - Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
AD  - Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil.
AD  - Programa de Pos-Graduacao em Psiquiatria e Ciencias do Comportamento, Porto 
      Alegre, Brazil.
FAU - Sica da Rocha, Neusa
AU  - Sica da Rocha N
AD  - Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
AD  - Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil.
AD  - Programa de Pos-Graduacao em Psiquiatria e Ciencias do Comportamento, Porto 
      Alegre, Brazil.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180308
PL  - Denmark
TA  - Bipolar Disord
JT  - Bipolar disorders
JID - 100883596
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adult
MH  - Anxiety/blood/physiopathology
MH  - Bipolar Disorder/blood/physiopathology
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Case-Control Studies
MH  - Cross-Sectional Studies
MH  - Depressive Disorder, Major/*blood/physiopathology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Psychomotor Disorders/*blood/physiopathology
OTO - NOTNLM
OT  - brain-derived neurotrophic factor
OT  - major depression
OT  - melancholic depression
OT  - psychomotor retardation
EDAT- 2018/03/09 06:00
MHDA- 2019/05/11 06:00
CRDT- 2018/03/09 06:00
PHST- 2018/03/09 06:00 [pubmed]
PHST- 2019/05/11 06:00 [medline]
PHST- 2018/03/09 06:00 [entrez]
AID - 10.1111/bdi.12636 [doi]
PST - ppublish
SO  - Bipolar Disord. 2018 Dec;20(8):746-752. doi: 10.1111/bdi.12636. Epub 2018 Mar 8.