PMID- 29517281
OWN - NLM
STAT- MEDLINE
DCOM- 20181101
LR  - 20181101
IS  - 1744-8301 (Electronic)
IS  - 1479-6694 (Linking)
VI  - 14
IP  - 16
DP  - 2018 Jul
TI  - YB-1 promotes laryngeal squamous cell carcinoma progression by inducing miR-155 
      expression via c-Myb.
PG  - 1579-1589
LID - 10.2217/fon-2018-0058 [doi]
AB  - AIM: In this study, we investigated the role of Y-box binding protein-1 (YB-1), 
      c-Myb and miR-155 in human laryngeal squamous cell carcinoma (LSCC) progression. 
      MATERIALS & METHODS: Quantitative real-time PCR, western blot, MTT and Transwell 
      were conducted to determine the expression and function of YB-1/miR-155 pathway. 
      Univariate and multivariate analyses were used to determine the prognostic 
      factors. RESULTS: Expression of YB-1, c-Myb and miR-155 was higher in LSCC 
      tissues. YB-1 promoted proliferation, invasiveness and migration of Hep-2 cells 
      in vitro. Patients with higher YB-1 correlated with advanced T stage, poor 
      differentiation and cervical metastasis. LSCC patients with high YB-1 expression 
      showed poor overall survival. CONCLUSION: YB-1 promotes LSCC progression by 
      increasing miR-155 levels via c-Myb and acts as a prognostic factor.
FAU - Zhao, Xudong
AU  - Zhao X
AD  - Department of Otorhinolaryngology, Shengjing Hospital, China Medical University, 
      Shenyang, 110004, PR China.
FAU - Zhang, Wei
AU  - Zhang W
AD  - Department of Endocrinology Shengjing Hospital, China Medical University, 
      Shenyang, 110004, PR China.
FAU - Ji, Wenyue
AU  - Ji W
AD  - Department of Otorhinolaryngology, Shengjing Hospital, China Medical University, 
      Shenyang, 110004, PR China.
LA  - eng
PT  - Journal Article
DEP - 20180308
PL  - England
TA  - Future Oncol
JT  - Future oncology (London, England)
JID - 101256629
RN  - 0 (MIRN155 microRNA, human)
RN  - 0 (MicroRNAs)
RN  - 0 (Y-Box-Binding Protein 1)
RN  - 0 (YBX1 protein, human)
SB  - IM
MH  - Aged
MH  - Carcinoma, Squamous Cell/genetics/mortality/*pathology/surgery
MH  - Cell Line, Tumor
MH  - Cell Movement/genetics
MH  - Cell Proliferation/genetics
MH  - Female
MH  - Gene Expression Regulation, Neoplastic
MH  - Genes, myb/*genetics
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Laryngeal Neoplasms/genetics/mortality/*pathology/surgery
MH  - Male
MH  - MicroRNAs/*genetics
MH  - Middle Aged
MH  - Prognosis
MH  - Y-Box-Binding Protein 1/*genetics/metabolism
OTO - NOTNLM
OT  - LSCC
OT  - YB-1
OT  - c-Myb
OT  - cervical metastasis
OT  - head and neck cancer
OT  - invasion
OT  - laryngeal cancer
OT  - miR-155
OT  - prognosis
OT  - proliferation
EDAT- 2018/03/09 06:00
MHDA- 2018/11/02 06:00
CRDT- 2018/03/09 06:00
PHST- 2018/03/09 06:00 [pubmed]
PHST- 2018/11/02 06:00 [medline]
PHST- 2018/03/09 06:00 [entrez]
AID - 10.2217/fon-2018-0058 [doi]
PST - ppublish
SO  - Future Oncol. 2018 Jul;14(16):1579-1589. doi: 10.2217/fon-2018-0058. Epub 2018 
      Mar 8.