PMID- 29517685
OWN - NLM
STAT- MEDLINE
DCOM- 20180319
LR  - 20210109
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 97
IP  - 10
DP  - 2018 Mar
TI  - The altered Granger causality connection among pain-related brain networks in 
      migraine.
PG  - e0102
LID - 10.1097/MD.0000000000010102 [doi]
LID - e0102
AB  - Numerous fMRI studies have confirmed functional abnormalities in resting-state 
      brain networks in migraine patients. However, few studies focusing on causal 
      relationships of pain-related brain networks in migraine have been conducted. 
      This study aims to explore the difference of Granger causality connection among 
      pain-related brain networks in migraine without aura (MWoA) patients.Twenty two 
      MWoA patients and 17 matched healthy subjects were recruited to undergo 
      resting-state fMRI scanning. Independent component analysis was used to extract 
      pain-related brain networks, and Granger causality analysis to characterize the 
      difference of Granger causality connection among pain-related brain networks was 
      employed.Seven pain-related brain networks were identified, and MwoA patients 
      showed more complex Granger causality connections in comparison with healthy 
      subjects. Two-sample t test results displayed that there was the significant 
      difference between right-frontoparietal network (RFPN) and executive control 
      network (ECN).This study indicates that the specific intrinsic brain Granger 
      causality connectivity among pain-related networks in MwoA patients are affected 
      after long-term migraine attacks.
FAU - Ning, Yanzhe
AU  - Ning Y
AD  - Department of Neurology and Stroke Center, Dongzhimen Hospital, the First 
      Affiliated Hospital of Beijing University of Chinese Medicine The National 
      Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental 
      Disorders, Beijing Anding Hospital, Capital Medical University Department of 
      Acupuncture and Moxibustion, Dongfang Hospital, The Second Affiliated Hospital of 
      Beijing University of Chinese Medicine Department of Internal Medicine, Gulou 
      Hospital of Traditional Chinese Medicine of Beijing.
FAU - Zheng, Ruwen
AU  - Zheng R
FAU - Li, Kuangshi
AU  - Li K
FAU - Zhang, Yong
AU  - Zhang Y
FAU - Lyu, Diyang
AU  - Lyu D
FAU - Jia, Hongxiao
AU  - Jia H
FAU - Ren, Yi
AU  - Ren Y
FAU - Zou, Yihuai
AU  - Zou Y
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
SB  - IM
MH  - Adult
MH  - Brain/diagnostic imaging/*physiopathology
MH  - Brain Mapping/methods
MH  - Case-Control Studies
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Migraine without Aura/complications/diagnostic imaging/*physiopathology
MH  - Nerve Net/diagnostic imaging/*physiopathology
MH  - Pain/diagnostic imaging/*etiology/physiopathology
MH  - Rest/physiology
PMC - PMC5882438
COIS- The authors have no conflicts of interest to disclose.
EDAT- 2018/03/09 06:00
MHDA- 2018/03/20 06:00
PMCR- 2018/03/09
CRDT- 2018/03/09 06:00
PHST- 2018/03/09 06:00 [entrez]
PHST- 2018/03/09 06:00 [pubmed]
PHST- 2018/03/20 06:00 [medline]
PHST- 2018/03/09 00:00 [pmc-release]
AID - 00005792-201803090-00030 [pii]
AID - MD-D-17-06445 [pii]
AID - 10.1097/MD.0000000000010102 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2018 Mar;97(10):e0102. doi: 10.1097/MD.0000000000010102.