PMID- 29518212
OWN - NLM
STAT- MEDLINE
DCOM- 20190328
LR  - 20190328
IS  - 2047-2412 (Electronic)
IS  - 2047-2404 (Linking)
VI  - 19
IP  - 8
DP  - 2018 Aug 1
TI  - Myocardial T1 mapping and extracellular volume quantification in patients with 
      left ventricular non-compaction cardiomyopathy.
PG  - 888-895
LID - 10.1093/ehjci/jey022 [doi]
AB  - AIMS: From pathophysiological mechanisms to risk stratification and management, 
      much debate and discussion persist regarding left ventricular non-compaction 
      cardiomyopathy (LVNC). This study aimed to characterize myocardial T1 mapping and 
      extracellular volume (ECV) fraction by cardiovascular magnetic resonance (CMR), 
      and investigate how these biomarkers relate to left ventricular ejection fraction 
      (LVEF) and ventricular arrhythmias (VA) in LVNC. METHODS AND RESULTS: Patients 
      with LVNC (n = 36) and healthy controls (n = 18) were enrolled to perform a CMR 
      with T1 mapping. ECV was quantified in LV segments without late gadolinium 
      enhancement (LGE) areas to investigate diffuse myocardial fibrosis. Patients with 
      LVNC had slightly higher native T1 (1024 +/- 43 ms vs. 995 +/- 22 ms, P = 0.01) and 
      substantially expanded ECV (28.0 +/- 4.5% vs. 23.5 +/- 2.2%, P < 0.001) compared to 
      controls. The ECV was independently associated with LVEF (beta = -1.3, P = 0.001). 
      Among patients without LGE, VAs were associated with higher ECV (27.7% with VA 
      vs. 25.8% without VA, P = 0.002). CONCLUSION: In LVNC, tissue characterization by 
      T1 mapping suggests an extracellular expansion by diffuse fibrosis in myocardium 
      without LGE, which was associated with myocardial dysfunction and VA, but not 
      with the amount of non-compacted myocardium.
FAU - Araujo-Filho, Jose A B
AU  - Araujo-Filho JAB
AD  - Department of Radiology and Oncology, Heart Institute (InCor), University of Sao 
      Paulo Medical School, Cardiovascular Magnetic Resonance and Computed Tomography 
      Sector, Av. Dr. Eneas de Carvalho Aguiar, 44, Andar AB, Cerqueira Cesar, Sao 
      Paulo, 05403-000 SP, Brazil.
FAU - Assuncao, Antonildes N Jr
AU  - Assuncao AN Jr
AD  - Department of Radiology and Oncology, Heart Institute (InCor), University of Sao 
      Paulo Medical School, Cardiovascular Magnetic Resonance and Computed Tomography 
      Sector, Av. Dr. Eneas de Carvalho Aguiar, 44, Andar AB, Cerqueira Cesar, Sao 
      Paulo, 05403-000 SP, Brazil.
FAU - Tavares de Melo, Marcelo D
AU  - Tavares de Melo MD
AD  - Heart Failure Unit, Heart Institute (InCor), University of Sao Paulo Medical 
      School, Av. Dr. Eneas de Carvalho Aguiar, 44, Andar AB, Cerqueira Cesar, Sao 
      Paulo, 05403-000 SP, Brazil.
FAU - Biere, Loic
AU  - Biere L
AD  - UMR CNRS 6015-INSERM U1083, Institute MitoVasc, University of Angers, 3 rue Roger 
      Amsler, 49100 Angers, France.
FAU - Lima, Camila R
AU  - Lima CR
AD  - Heart Failure Unit, Heart Institute (InCor), University of Sao Paulo Medical 
      School, Av. Dr. Eneas de Carvalho Aguiar, 44, Andar AB, Cerqueira Cesar, Sao 
      Paulo, 05403-000 SP, Brazil.
FAU - Dantas, Roberto N Jr
AU  - Dantas RN Jr
AD  - Department of Radiology and Oncology, Heart Institute (InCor), University of Sao 
      Paulo Medical School, Cardiovascular Magnetic Resonance and Computed Tomography 
      Sector, Av. Dr. Eneas de Carvalho Aguiar, 44, Andar AB, Cerqueira Cesar, Sao 
      Paulo, 05403-000 SP, Brazil.
FAU - Nomura, Cesar H
AU  - Nomura CH
AD  - Department of Radiology and Oncology, Heart Institute (InCor), University of Sao 
      Paulo Medical School, Cardiovascular Magnetic Resonance and Computed Tomography 
      Sector, Av. Dr. Eneas de Carvalho Aguiar, 44, Andar AB, Cerqueira Cesar, Sao 
      Paulo, 05403-000 SP, Brazil.
FAU - Salemi, Vera M C
AU  - Salemi VMC
AD  - Heart Failure Unit, Heart Institute (InCor), University of Sao Paulo Medical 
      School, Av. Dr. Eneas de Carvalho Aguiar, 44, Andar AB, Cerqueira Cesar, Sao 
      Paulo, 05403-000 SP, Brazil.
FAU - Jerosch-Herold, Michael
AU  - Jerosch-Herold M
AD  - Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, 75 
      Francis St, Boston, 02115 Massachusetts, USA.
FAU - Parga, Jose R
AU  - Parga JR
AD  - Department of Radiology and Oncology, Heart Institute (InCor), University of Sao 
      Paulo Medical School, Cardiovascular Magnetic Resonance and Computed Tomography 
      Sector, Av. Dr. Eneas de Carvalho Aguiar, 44, Andar AB, Cerqueira Cesar, Sao 
      Paulo, 05403-000 SP, Brazil.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Eur Heart J Cardiovasc Imaging
JT  - European heart journal. Cardiovascular Imaging
JID - 101573788
RN  - Noncompaction of Left Ventricular Myocardium with Congenital Heart Defects
SB  - IM
MH  - Adult
MH  - Body Surface Potential Mapping/*methods
MH  - Cardiomyopathies/*diagnostic imaging/*pathology
MH  - Case-Control Studies
MH  - Female
MH  - Fibrosis/diagnostic imaging/pathology
MH  - Follow-Up Studies
MH  - Heart Defects, Congenital
MH  - Humans
MH  - Magnetic Resonance Imaging, Cine/*methods
MH  - Male
MH  - Middle Aged
MH  - Reference Values
MH  - Risk Assessment
MH  - Stroke Volume/physiology
MH  - Ventricular Function, Left/physiology
EDAT- 2018/03/09 06:00
MHDA- 2019/03/29 06:00
CRDT- 2018/03/09 06:00
PHST- 2017/08/17 00:00 [received]
PHST- 2018/02/06 00:00 [accepted]
PHST- 2018/03/09 06:00 [pubmed]
PHST- 2019/03/29 06:00 [medline]
PHST- 2018/03/09 06:00 [entrez]
AID - 4922688 [pii]
AID - 10.1093/ehjci/jey022 [doi]
PST - ppublish
SO  - Eur Heart J Cardiovasc Imaging. 2018 Aug 1;19(8):888-895. doi: 
      10.1093/ehjci/jey022.