PMID- 29518524
OWN - NLM
STAT- MEDLINE
DCOM- 20190130
LR  - 20190130
IS  - 1569-1802 (Electronic)
IS  - 0945-053X (Linking)
VI  - 68-69
DP  - 2018 Aug
TI  - The impaired proteases and anti-proteases balance in Idiopathic Pulmonary 
      Fibrosis.
PG  - 382-403
LID - S0945-053X(17)30471-7 [pii]
LID - 10.1016/j.matbio.2018.03.001 [doi]
AB  - Idiopathic Pulmonary Fibrosis (IPF) is a devastating chronic, progressive and 
      irreversible disease that remains refractory to current therapies. Matrix 
      metalloproteinases (MMPs) and their inhibitors, tissue inhibitors of MMPs 
      (TIMPs), have been implicated in the development of pulmonary fibrosis since 
      decades. Coagulation signalling deregulation, which influences several key 
      inflammatory and fibro-proliferative responses, is also essential in IPF 
      pathogenesis, and a growing body of evidence indicates that Protease-Activated 
      Receptors (PARs) inhibition in IPF may be promising for future evaluation. 
      Therefore, proteases and anti-proteases aroused great biomedical interest over 
      the past years, owing to the identification of their potential roles in lung 
      fibrosis. During these last decades, numerous other proteases and anti-proteases 
      have been studied in lung fibrosis, such as matriptase, Human airway trypsin-like 
      protease (HAT), Hepatocyte growth factor activator (HGFA)/HGFA activator 
      inhibitor (HAI) system, Plasminogen activator inhibitor (PAI)-1, Protease nexine 
      (PN)-1, cathepsins, calpains, and cystatin C. Herein, we provide a general 
      overview of the proteases and anti-proteases unbalance during lung fibrogenesis 
      and explore potential therapeutics for IPF.
CI  - Copyright (c) 2018. Published by Elsevier B.V.
FAU - Menou, Awen
AU  - Menou A
AD  - Institut National de la Sante Et de la Recherche Medicale, U1152 Paris, France; 
      Departement Hospitalo, Universitaire FIRE, Paris, France; Laboratoire 
      d'Excellence Inflamex, Paris, France; Universite Paris Diderot - Paris 7, 
      Sorbonne Paris Cite, Paris, France.
FAU - Duitman, JanWillem
AU  - Duitman J
AD  - Institut National de la Sante Et de la Recherche Medicale, U1152 Paris, France; 
      Departement Hospitalo, Universitaire FIRE, Paris, France; Laboratoire 
      d'Excellence Inflamex, Paris, France; Universite Paris Diderot - Paris 7, 
      Sorbonne Paris Cite, Paris, France.
FAU - Crestani, Bruno
AU  - Crestani B
AD  - Institut National de la Sante Et de la Recherche Medicale, U1152 Paris, France; 
      Departement Hospitalo, Universitaire FIRE, Paris, France; Laboratoire 
      d'Excellence Inflamex, Paris, France; Universite Paris Diderot - Paris 7, 
      Sorbonne Paris Cite, Paris, France; Assistance Publique-Hopitaux de Paris, 
      Hopital Bichat, Service de Pneumologie A, Paris, France. Electronic address: 
      bruno.crestani@aphp.fr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20180306
PL  - Netherlands
TA  - Matrix Biol
JT  - Matrix biology : journal of the International Society for Matrix Biology
JID - 9432592
RN  - 0 (Proteinase Inhibitory Proteins, Secretory)
RN  - 0 (Tissue Inhibitor of Metalloproteinases)
RN  - EC 3.4.- (Peptide Hydrolases)
RN  - EC 3.4.24.- (Matrix Metalloproteinases)
SB  - IM
MH  - Gene Expression Regulation
MH  - Humans
MH  - Idiopathic Pulmonary Fibrosis/*metabolism
MH  - Matrix Metalloproteinases/metabolism
MH  - Peptide Hydrolases/*metabolism
MH  - Proteinase Inhibitory Proteins, Secretory/*metabolism
MH  - Signal Transduction
MH  - Tissue Inhibitor of Metalloproteinases/metabolism
OTO - NOTNLM
OT  - Anti-protease
OT  - Cysteine protease
OT  - Idiopathic Pulmonary Fibrosis
OT  - Matrix metalloproteinase
OT  - Serine protease
EDAT- 2018/03/09 06:00
MHDA- 2019/01/31 06:00
CRDT- 2018/03/09 06:00
PHST- 2017/12/15 00:00 [received]
PHST- 2018/02/28 00:00 [revised]
PHST- 2018/03/01 00:00 [accepted]
PHST- 2018/03/09 06:00 [pubmed]
PHST- 2019/01/31 06:00 [medline]
PHST- 2018/03/09 06:00 [entrez]
AID - S0945-053X(17)30471-7 [pii]
AID - 10.1016/j.matbio.2018.03.001 [doi]
PST - ppublish
SO  - Matrix Biol. 2018 Aug;68-69:382-403. doi: 10.1016/j.matbio.2018.03.001. Epub 2018 
      Mar 6.