PMID- 29519513
OWN - NLM
STAT- MEDLINE
DCOM- 20181120
LR  - 20191210
IS  - 1873-2542 (Electronic)
IS  - 0378-1135 (Linking)
VI  - 216
DP  - 2018 Mar
TI  - Efficacy evaluation of two commercial modified-live virus vaccines against a 
      novel recombinant type 2 porcine reproductive and respiratory syndrome virus.
PG  - 176-182
LID - S0378-1135(17)31305-6 [pii]
LID - 10.1016/j.vetmic.2018.02.016 [doi]
AB  - NADC30-like porcine reproductive and respiratory syndrome virus (PRRSV) causing 
      clinical disease outbreaks has been recently reported in China. The recombination 
      occurring among PRRSV strains could lead to the emergence of novel and more 
      virulent viruses. In our previous study, a novel recombinant type 2 PRRSV 
      (TJnh1501) between NADC30-like and modified-live virus (MLV)-like derived from 
      the Chinese highly pathogenic PRRSV was shown to have higher pathogenicity than 
      NADC30-like PRRSV. It remains unknown whether the emergence of the novel 
      recombinant PRRSV strain can lead to variable protection efficacy of the MLV 
      vaccines. In this paper, two typical commercial MLV vaccines were used to 
      evaluate their efficacy to block TJnh1501 infection and onset of clinical 
      symptoms. Our results showed that both MLV vaccines could shorten the period of 
      fever and reduce viral loads in sera, but were not able to reduce the clinical 
      signs and lung lesions indicating that the two commercial MLV vaccines provide 
      limited cross-protection efficacy against the novel recombinant type 2 PRRSV 
      infection. This study gives valuable suggestions for the use of MLV vaccines to 
      control PRRSV infection in the field.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Sun, Ying-Feng
AU  - Sun YF
AD  - College of Animal Science and Veterinary Medicine, Tianjin Agricultural 
      University, Tianjin 300384, China; Key Laboratory of Animal Epidemiology of the 
      Ministry of Agriculture, College of Veterinary Medicine and State Key Laboratory 
      of Agrobiotechnology, China Agricultural University, Beijing 100193, China.
FAU - Zhou, Lei
AU  - Zhou L
AD  - Key Laboratory of Animal Epidemiology of the Ministry of Agriculture, College of 
      Veterinary Medicine and State Key Laboratory of Agrobiotechnology, China 
      Agricultural University, Beijing 100193, China.
FAU - Bian, Ting
AU  - Bian T
AD  - Key Laboratory of Animal Epidemiology of the Ministry of Agriculture, College of 
      Veterinary Medicine and State Key Laboratory of Agrobiotechnology, China 
      Agricultural University, Beijing 100193, China.
FAU - Tian, Xiang-Xue
AU  - Tian XX
AD  - Tianjin Animal Husbandry and Veterinary Research Institute, Tianjin 300381, 
      China.
FAU - Ren, Wei-Ke
AU  - Ren WK
AD  - Tianjin Animal Husbandry and Veterinary Research Institute, Tianjin 300381, 
      China.
FAU - Lu, Chao
AU  - Lu C
AD  - Tianjin Animal Husbandry and Veterinary Research Institute, Tianjin 300381, 
      China.
FAU - Zhang, Li
AU  - Zhang L
AD  - Tianjin Animal Husbandry and Veterinary Research Institute, Tianjin 300381, 
      China.
FAU - Li, Xiu-Li
AU  - Li XL
AD  - Tianjin Animal Husbandry and Veterinary Research Institute, Tianjin 300381, 
      China.
FAU - Cui, Mao-Sheng
AU  - Cui MS
AD  - Tianjin Animal Husbandry and Veterinary Research Institute, Tianjin 300381, 
      China.
FAU - Yang, Han-Chun
AU  - Yang HC
AD  - Key Laboratory of Animal Epidemiology of the Ministry of Agriculture, College of 
      Veterinary Medicine and State Key Laboratory of Agrobiotechnology, China 
      Agricultural University, Beijing 100193, China. Electronic address: 
      yanghanchun1@cau.edu.cn.
FAU - Yu, Hai
AU  - Yu H
AD  - Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 
      Shanghai 200241, China; Jiangsu Co-Innovation Center for Prevention and Control 
      of Important Animal Infectious Diseases and Zoonoses, Yangzhou 225009, China. 
      Electronic address: haiyu_008@126.com.
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
DEP - 20180212
PL  - Netherlands
TA  - Vet Microbiol
JT  - Veterinary microbiology
JID - 7705469
RN  - 0 (Antibodies, Viral)
RN  - 0 (Vaccines, Attenuated)
RN  - 0 (Viral Vaccines)
SB  - IM
MH  - Animals
MH  - Antibodies, Viral/blood
MH  - Cross Protection
MH  - Phylogeny
MH  - Porcine Reproductive and Respiratory Syndrome/immunology/*prevention & control
MH  - Porcine respiratory and reproductive syndrome 
      virus/genetics/*immunology/isolation & purification
MH  - *Recombination, Genetic
MH  - Swine
MH  - Vaccine Potency
MH  - Vaccines, Attenuated/administration & dosage/*immunology
MH  - Viral Load
MH  - Viral Vaccines/*immunology
MH  - Virulence
OTO - NOTNLM
OT  - Commercial MLV vaccines
OT  - Efficacy evaluation
OT  - Novel recombinant type 2 PRRSV
EDAT- 2018/03/10 06:00
MHDA- 2018/11/21 06:00
CRDT- 2018/03/10 06:00
PHST- 2017/11/09 00:00 [received]
PHST- 2018/02/08 00:00 [revised]
PHST- 2018/02/11 00:00 [accepted]
PHST- 2018/03/10 06:00 [entrez]
PHST- 2018/03/10 06:00 [pubmed]
PHST- 2018/11/21 06:00 [medline]
AID - S0378-1135(17)31305-6 [pii]
AID - 10.1016/j.vetmic.2018.02.016 [doi]
PST - ppublish
SO  - Vet Microbiol. 2018 Mar;216:176-182. doi: 10.1016/j.vetmic.2018.02.016. Epub 2018 
      Feb 12.