PMID- 29520002
OWN - NLM
STAT- MEDLINE
DCOM- 20181016
LR  - 20200225
IS  - 2158-3188 (Electronic)
IS  - 2158-3188 (Linking)
VI  - 7
IP  - 11
DP  - 2018 Mar 9
TI  - Stimulated left DLPFC-nucleus accumbens functional connectivity predicts the 
      anti-depression and anti-anxiety effects of rTMS for depression.
PG  - 3
LID - 10.1038/s41398-017-0005-6 [doi]
LID - 3
AB  - Not all depression patients effectively respond to repeated transcranial magnetic 
      stimulation (rTMS). We tested whether the intrinsic functional connectivity (FC) 
      strength between the stimulated left dorsolateral prefrontal cortex (DLPFC) and 
      left nucleus accumbens (NAcc) might predict effects of rTMS. Twenty-two 
      medication-naive depression patients received rTMS on left DLPFC for 2 weeks and 
      underwent baseline functional magnetic resonance imaging (fMRI). We compared the 
      amplitude of the low-frequency fluctuation (ALFF) and regional homogeneity (ReHo) 
      in the stimulated target (the cortex region directly stimulated by rTMS) located 
      in the left DLPFC, and the left NAcc, as well as the intrinsic FC of the 
      DLPFC-NAcc between early improvers and non-improvers. We evaluated the 
      association between the baseline brain imaging features (ALFF, ReHo, and FC) and 
      improvements in depression and anxiety symptoms. We found that the pretreatment 
      ALFF and ReHo in the stimulated DLPFC and left NAcc did not significantly differ 
      between the subgroups. The early improvers displayed increased negative FC 
      strength between the stimulated DLPFC and left NAcc with respect to 
      non-improvers. The stimulated DLPFC-NAcc FC strength negatively correlated with 
      improved depressive and anxious symptoms. This study is the first to demonstrate 
      that the resting-state FC of the stimulated DLPFC-NAcc, rather than regional 
      brain activity or local synchronization in the stimulated target, might predict 
      the anti-depression and anti-anxiety effects of rTMS for depression.
FAU - Du, Lian
AU  - Du L
AD  - Department of Psychiatry, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing, 400016, P.R. China.
AD  - Laboratory of Stem Cells and Tissue Engineering, Chongqing Medical University, 
      Chongqing, 400016, P.R. China.
FAU - Liu, Huan
AU  - Liu H
AD  - Department of Psychiatry, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing, 400016, P.R. China.
FAU - Du, Wanyi
AU  - Du W
AD  - Department of Psychiatry, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing, 400016, P.R. China.
FAU - Chao, Fenglei
AU  - Chao F
AD  - Laboratory of Stem Cells and Tissue Engineering, Chongqing Medical University, 
      Chongqing, 400016, P.R. China.
AD  - Department of Histology and Embryology, Chongqing Medical University, Chongqing, 
      400016, P.R. China.
FAU - Zhang, Lei
AU  - Zhang L
AD  - Laboratory of Stem Cells and Tissue Engineering, Chongqing Medical University, 
      Chongqing, 400016, P.R. China.
AD  - Department of Histology and Embryology, Chongqing Medical University, Chongqing, 
      400016, P.R. China.
FAU - Wang, Kejian
AU  - Wang K
AD  - Department of Anatomy, Chongqing Medical University, Chongqing, 400016, P.R. 
      China.
FAU - Huang, Chunxia
AU  - Huang C
AD  - Department of Physiology, Chongqing Medical University, Chongqing, 400016, P.R. 
      China.
FAU - Gao, Yuan
AU  - Gao Y
AD  - Department of Geriatrics, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing, 400016, P.R. China.
FAU - Tang, Yong
AU  - Tang Y
AD  - Laboratory of Stem Cells and Tissue Engineering, Chongqing Medical University, 
      Chongqing, 400016, P.R. China. ytang062@163.com.
AD  - Department of Histology and Embryology, Chongqing Medical University, Chongqing, 
      400016, P.R. China. ytang062@163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180309
PL  - United States
TA  - Transl Psychiatry
JT  - Translational psychiatry
JID - 101562664
SB  - IM
MH  - Adult
MH  - Anxiety Disorders/*therapy
MH  - Connectome/*methods
MH  - Depressive Disorder/*therapy
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Nucleus Accumbens/diagnostic imaging/*physiopathology
MH  - Outcome Assessment, Health Care/*methods
MH  - Prefrontal Cortex/diagnostic imaging/*physiopathology
MH  - Transcranial Magnetic Stimulation/*methods
MH  - Young Adult
PMC - PMC5843586
COIS- The authors declare that they have no competing interests.
EDAT- 2018/03/10 06:00
MHDA- 2018/10/17 06:00
PMCR- 2018/03/09
CRDT- 2018/03/10 06:00
PHST- 2017/02/11 00:00 [received]
PHST- 2017/08/20 00:00 [accepted]
PHST- 2018/03/10 06:00 [entrez]
PHST- 2018/03/10 06:00 [pubmed]
PHST- 2018/10/17 06:00 [medline]
PHST- 2018/03/09 00:00 [pmc-release]
AID - 10.1038/s41398-017-0005-6 [pii]
AID - 5 [pii]
AID - 10.1038/s41398-017-0005-6 [doi]
PST - epublish
SO  - Transl Psychiatry. 2018 Mar 9;7(11):3. doi: 10.1038/s41398-017-0005-6.