PMID- 29520182 OWN - NLM STAT- MEDLINE DCOM- 20190130 LR - 20190130 IS - 2005-8330 (Electronic) IS - 1229-6929 (Print) IS - 1229-6929 (Linking) VI - 19 IP - 2 DP - 2018 Mar-Apr TI - Self-Gated Late Gadolinium Enhancement at 7T to Image Rats with Reperfused Acute Myocardial Infarction. PG - 247-255 LID - 10.3348/kjr.2018.19.2.247 [doi] AB - OBJECTIVE: A failed electrocardiography (ECG)-trigger often leads to a long acquisition time (TA) and deterioration in image quality. The purpose of this study was to evaluate and optimize the technique of self-gated (SG) cardiovascular magnetic resonance (CMR) for cardiac late gadolinium enhancement (LGE) imaging of rats with myocardial infarction/reperfusion. MATERIALS AND METHODS: Cardiovascular magnetic resonance images of 10 rats were obtained using SG-LGE or ECG with respiration double-gating (ECG-RESP-gating) method at 7T to compare differences in image interference and TA between the two methods. A variety of flip angles (FA: 10 degrees -80 degrees ) and the number of repetitions (NR: 40, 80, 150, and 300) were investigated to determine optimal scan parameters of SG-LGE technique based on image quality score and contrast-to-noise ratio (CNR). RESULTS: Self-gated late gadolinium enhancement allowed successful scan in 10 (100%) rats. However, only 4 (40%) rats were successfully scanned with the ECG-RESP-gating method. TAs with SG-LGE varied depending on NR used (TA: 41, 82, 154, and 307 seconds, corresponding to NR of 40, 80, 150, and 300, respectively). For the ECG-RESP-gating method, the average TA was 220 seconds. For SG-LGE images, CNR (42.5 +/- 5.5, 43.5 +/- 7.5, 54 +/- 9, 59.5 +/- 8.5, 56 +/- 13, 54 +/- 8, and 41 +/- 9) and image quality score (1.85 +/- 0.75, 2.20 +/- 0.83, 2.85 +/- 0.37, 3.85 +/- 0.52, 2.8 +/- 0.51, 2.45 +/- 0.76, and 1.95 +/- 0.60) were achieved with different FAs (10 degrees , 15 degrees , 20 degrees , 25 degrees , 30 degrees , 35 degrees , and 40 degrees , respectively). Optimal FAs of 20 degrees -30 degrees and NR of 80 were recommended. CONCLUSION: Self-gated technique can improve image quality of LGE without irregular ECG or respiration gating. Therefore, SG-LGE can be used an alternative method of ECG-RESP-gating. FAU - Wang, Lei AU - Wang L AD - Molecular Imaging Center, West China Hospital of Sichuan University, Chengdu 610041, China. FAU - Chen, Yushu AU - Chen Y AD - Department of Radiology, West China Hospital of Sichuan University, Chengdu 610041, China. FAU - Zhang, Bing AU - Zhang B AD - Department of Radiology, West China Hospital of Sichuan University, Chengdu 610041, China. FAU - Chen, Wei AU - Chen W AD - Department of Radiology, West China Hospital of Sichuan University, Chengdu 610041, China. FAU - Wang, Chunhua AU - Wang C AD - Department of Radiology, West China Hospital of Sichuan University, Chengdu 610041, China. FAU - Song, Li AU - Song L AD - Molecular Imaging Center, West China Hospital of Sichuan University, Chengdu 610041, China. FAU - Xu, Ziqian AU - Xu Z AD - Department of Radiology, West China Hospital of Sichuan University, Chengdu 610041, China. FAU - Zheng, Jie AU - Zheng J AD - Mallinckrodt Institute of Radiology, Washington University School of Medicine in St. Louis, MO 63110, USA. FAU - Gao, Fabao AU - Gao F AD - Department of Radiology, West China Hospital of Sichuan University, Chengdu 610041, China. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20180222 PL - Korea (South) TA - Korean J Radiol JT - Korean journal of radiology JID - 100956096 RN - 0 (Contrast Media) RN - AU0V1LM3JT (Gadolinium) SB - IM MH - Animals MH - Contrast Media/*chemistry MH - Electrocardiography MH - Gadolinium/*chemistry MH - Image Enhancement MH - *Magnetic Resonance Imaging MH - Male MH - Myocardial Infarction/*diagnosis/diagnostic imaging/veterinary MH - Rats MH - Rats, Sprague-Dawley PMC - PMC5840053 OTO - NOTNLM OT - 7T OT - Animal studies OT - Flip angle OT - Late gadolinium enhancement OT - MRI OT - Myocardial infarction OT - Self-gated EDAT- 2018/03/10 06:00 MHDA- 2019/01/31 06:00 PMCR- 2018/03/01 CRDT- 2018/03/10 06:00 PHST- 2017/02/03 00:00 [received] PHST- 2017/07/28 00:00 [accepted] PHST- 2018/03/10 06:00 [entrez] PHST- 2018/03/10 06:00 [pubmed] PHST- 2019/01/31 06:00 [medline] PHST- 2018/03/01 00:00 [pmc-release] AID - 10.3348/kjr.2018.19.2.247 [doi] PST - ppublish SO - Korean J Radiol. 2018 Mar-Apr;19(2):247-255. doi: 10.3348/kjr.2018.19.2.247. Epub 2018 Feb 22.