PMID- 29520199
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220409
IS  - 1318-2099 (Print)
IS  - 1581-3207 (Electronic)
IS  - 1318-2099 (Linking)
VI  - 52
IP  - 1
DP  - 2018 Mar
TI  - Helicobacter Pylori Treatment Results in Slovenia in the Period 2013-2015 as a 
      Part of European Registry on Helicobacter Pylori Management.
PG  - 1-6
LID - 10.1515/raon-2017-0055 [doi]
AB  - BACKGROUND: Helicobacter pylori (H. pylori) is the most common chronic bacterial 
      infection in the world affecting over 50% of the world's population. H. pylori is 
      a grade I carcinogen, responsible for the development of 89 % of noncardia 
      gastric cancers. In the present study we analyzed the data for H. pylori 
      eradication treatments in Slovenia. PATIENTS AND METHODS: Slovenia is a part of 
      the European Registry on Helicobacter pylori Management from the beginning. In 
      seven medical institutions data for H. pylori eradication treatments was 
      collected for 1774 patients from April 16(th) 2013 to May 15(th) 2016. For 
      further modified intention to treat (mITT) analysis 1519 patients were eligible 
      and for per protocol (PP) analysis 1346 patients. RESULTS: Patients' dropout was 
      11.4%. Eradication rate for 7 day triple therapy with proton pump inhibitor (PPI) 
      + Clarithromycin (C) + Amoxicillin (A) was 88.7% PP and 72.0% mITT; for PPI + C + 
      Metronidazole (M) 85.2% PP and 84.4% mITT. Second line 14 day therapy PPI + A + 
      Levofloxacin had 92.3% eradication rate PP and 87.1% mITT. Ten to fourteen day 
      Bismuth quadruple therapy was the therapy in difficult to treat patients. At the 
      end all patients that adhered to prescribed regimens were cured of their H. 
      pylori infection. CONCLUSIONS: High dropout rate deserves further analysis. 
      Slovenia is still a country with < 15% H. pylori resistance to clarithromycin, 
      triple therapy with PPI plus two antibiotics reaches PP eradication rate > 85%, 
      but mITT eradication rates are suboptimal.
FAU - Tepes, Bojan
AU  - Tepes B
AD  - Abakus Medico, Diagnostic Center Rogaska, Rogaska Slatina, Slovenia.
FAU - Kastelic, Marko
AU  - Kastelic M
AD  - Abakus Medico, Diagnostic Center Rogaska, Rogaska Slatina, Slovenia.
FAU - Vujasinovic, Miroslav
AU  - Vujasinovic M
AD  - General Hospital Slovenj Gradec, Slovenj Gradec, Slovenia.
FAU - Lampic, Polona
AU  - Lampic P
AD  - Diagnostic Center Bled, Bled, Slovenia.
FAU - Seruga, Maja
AU  - Seruga M
AD  - General Hospital Murska Sobota, Murska Sobota, Slovenia.
FAU - Jurecic, Natasa Brglez
AU  - Jurecic NB
AD  - General Hospital Trbovlje, Trbovlje, Slovenia.
FAU - Nyssen, Olga P
AU  - Nyssen OP
AD  - Gastroenterology Unit, Hospital Universitario de La Princesa, Instituto de 
      Investigacion Sanitaria Princesa (IIS-IP) and Centro de Investigacion Biomedica 
      en Red de Enfermedades Hepaticas y Digestivas (CIBEREHD), Madrid, Spain.
FAU - Donday, Maria G
AU  - Donday MG
AD  - Gastroenterology Unit, Hospital Universitario de La Princesa, Instituto de 
      Investigacion Sanitaria Princesa (IIS-IP) and Centro de Investigacion Biomedica 
      en Red de Enfermedades Hepaticas y Digestivas (CIBEREHD), Madrid, Spain.
FAU - O'Morain, Colm
AU  - O'Morain C
AD  - Beacon Consultants Clinic, Dublin, Ireland.
FAU - Megraud, Francis
AU  - Megraud F
AD  - Laboratoire de Bacteriologie-Enfants Hopital Pellegrin 33076Bordeaux cedex, 
      France.
FAU - McNicholl, Adrian G
AU  - McNicholl AG
AD  - Gastroenterology Unit, Hospital Universitario de La Princesa, Instituto de 
      Investigacion Sanitaria Princesa (IIS-IP) and Centro de Investigacion Biomedica 
      en Red de Enfermedades Hepaticas y Digestivas (CIBEREHD), Madrid, Spain.
FAU - Gisbert, Javier P
AU  - Gisbert JP
AD  - Gastroenterology Unit, Hospital Universitario de La Princesa, Instituto de 
      Investigacion Sanitaria Princesa (IIS-IP) and Centro de Investigacion Biomedica 
      en Red de Enfermedades Hepaticas y Digestivas (CIBEREHD), Madrid, Spain.
LA  - eng
PT  - Journal Article
DEP - 20171207
PL  - Poland
TA  - Radiol Oncol
JT  - Radiology and oncology
JID - 9317213
PMC - PMC5839075
OTO - NOTNLM
OT  - European Registry on Helicobacter pylori management
OT  - Helicobacter pylori
OT  - Slovenian results
OT  - eradication treatment
COIS- Disclosure: No potential conflicts of interest were disclosed.
EDAT- 2018/03/10 06:00
MHDA- 2018/03/10 06:01
PMCR- 2018/03/01
CRDT- 2018/03/10 06:00
PHST- 2017/09/11 00:00 [received]
PHST- 2017/11/05 00:00 [accepted]
PHST- 2018/03/10 06:00 [entrez]
PHST- 2018/03/10 06:00 [pubmed]
PHST- 2018/03/10 06:01 [medline]
PHST- 2018/03/01 00:00 [pmc-release]
AID - raon-2017-0055 [pii]
AID - 10.1515/raon-2017-0055 [doi]
PST - epublish
SO  - Radiol Oncol. 2017 Dec 7;52(1):1-6. doi: 10.1515/raon-2017-0055. eCollection 2018 
      Mar.