PMID- 29520783
OWN - NLM
STAT- MEDLINE
DCOM- 20191126
LR  - 20220531
IS  - 1943-3670 (Electronic)
IS  - 0022-3492 (Linking)
VI  - 89
IP  - 3
DP  - 2018 Mar
TI  - The KCNQ1 gene polymorphism as a shared genetic risk for rheumatoid arthritis and 
      chronic periodontitis in Japanese adults: A pilot case-control study.
PG  - 315-324
LID - 10.1002/JPER.17-0412 [doi]
AB  - BACKGROUND: A number of studies have suggested a bidirectional relationship of 
      periodontitis with rheumatoid arthritis (RA) and type 2 diabetes mellitus (T2DM). 
      However, the genetic factors that underlie these relationships have not been 
      elucidated. METHODS: We conducted a multicenter case-control study that included 
      185 patients with RA and chronic periodontitis (CP), 149 patients with T2DM and 
      CP, 251 patients with CP, and 130 systemically and periodontally healthy controls 
      from a cohort of Japanese adults to assess the shared genetic risk factors for RA 
      and CP as well as for T2DM and CP. A total of 17 candidate single nucleotide 
      polymorphisms (SNPs) associated with RA, T2DM, and CP were genotyped. RESULTS: 
      Multiple logistic regression analyses revealed that the KCNQ1 rs2237892 was 
      significantly associated with comorbidity of RA and CP (P = 0.005) after 
      adjustment for age, sex, and smoking status. The carriers of the T allele among 
      patients with RA and CP showed significantly higher disease activity scores 
      including 28 joints using C-reactive protein values than the non-carriers 
      (P = 0.02), although the age, female percentage, and smoking status were 
      comparable. Other SNPs were not associated with comorbidity of RA and CP, T2DM 
      and CP, or susceptibility to CP. CONCLUSION: The results of the present pilot 
      study suggest for the first time that the KCNQ1 rs2237892 may constitute a shared 
      genetic risk factor for RA and CP, but not for T2DM and CP in Japanese adults.
CI  - (c) 2018 American Academy of Periodontology.
FAU - Kobayashi, Tetsuo
AU  - Kobayashi T
AD  - General Dentistry and Clinical Education Unit, Niigata University Medical and 
      Dental Hospital.
AD  - Division of Periodontology, Niigata University Graduate School of Medical and 
      Dental Sciences.
FAU - Kido, Jun-Ichi
AU  - Kido JI
AD  - Department of Periodontology and Endodontology, Institute of Biomedical Sciences, 
      Tokushima University Graduate School.
FAU - Ishihara, Yuichi
AU  - Ishihara Y
AD  - Department of Operative Dentistry, Endodontology, and Periodontology, School of 
      Dentistry, Matsumoto Dental University.
FAU - Omori, Kazuhiro
AU  - Omori K
AD  - Department of Periodontics and Endodontics, Okayama University Hospital.
FAU - Ito, Satoshi
AU  - Ito S
AD  - Department of Rheumatology, Niigata Rheumatic Center.
FAU - Matsuura, Takato
AU  - Matsuura T
AD  - Department of Periodontology, School of Dentistry, Aichi Gakuin University.
FAU - Bando, Takashi
AU  - Bando T
AD  - Department of Dentistry, Kawashima Hospital.
FAU - Wada, Jun
AU  - Wada J
AD  - Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama 
      University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences.
FAU - Murasawa, Akira
AU  - Murasawa A
AD  - Department of Rheumatology, Niigata Rheumatic Center.
FAU - Nakazono, Kiyoshi
AU  - Nakazono K
AD  - Department of Rheumatology, Niigata Rheumatic Center.
FAU - Mitani, Akio
AU  - Mitani A
AD  - Department of Periodontology, School of Dentistry, Aichi Gakuin University.
FAU - Takashiba, Shogo
AU  - Takashiba S
AD  - Department of Pathophysiology-Periodontal Science, Okayama University Graduate 
      School of Medicine, Dentistry and Pharmaceutical Sciences.
FAU - Nagata, Toshihiko
AU  - Nagata T
AD  - Department of Periodontology and Endodontology, Institute of Biomedical Sciences, 
      Tokushima University Graduate School.
FAU - Yoshie, Hiromasa
AU  - Yoshie H
AD  - Division of Periodontology, Niigata University Graduate School of Medical and 
      Dental Sciences.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180312
PL  - United States
TA  - J Periodontol
JT  - Journal of periodontology
JID - 8000345
RN  - 0 (KCNQ1 Potassium Channel)
RN  - 0 (KCNQ1 protein, human)
SB  - IM
MH  - Adult
MH  - Arthritis, Rheumatoid/*genetics
MH  - Case-Control Studies
MH  - Chronic Periodontitis/*genetics
MH  - Diabetes Mellitus, Type 2/*genetics
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Japan
MH  - KCNQ1 Potassium Channel/*genetics
MH  - Pilot Projects
MH  - Polymorphism, Single Nucleotide
MH  - Risk Factors
OTO - NOTNLM
OT  - Arthritis, rheumatoid
OT  - case-control studies
OT  - comorbidity
OT  - diabetes mellitus
OT  - periodontitis
OT  - polymorphism, single nucleotide
EDAT- 2018/03/10 06:00
MHDA- 2019/11/27 06:00
CRDT- 2018/03/10 06:00
PHST- 2017/07/04 00:00 [received]
PHST- 2017/08/20 00:00 [revised]
PHST- 2017/09/17 00:00 [accepted]
PHST- 2018/03/10 06:00 [pubmed]
PHST- 2019/11/27 06:00 [medline]
PHST- 2018/03/10 06:00 [entrez]
AID - 10.1002/JPER.17-0412 [doi]
PST - ppublish
SO  - J Periodontol. 2018 Mar;89(3):315-324. doi: 10.1002/JPER.17-0412. Epub 2018 Mar 
      12.