PMID- 29521010
OWN - NLM
STAT- MEDLINE
DCOM- 20191209
LR  - 20211204
IS  - 1751-7893 (Electronic)
IS  - 1751-7885 (Linking)
VI  - 13
IP  - 4
DP  - 2019 Aug
TI  - Medication adherence in first-episode psychosis patients in Singapore.
PG  - 780-788
LID - 10.1111/eip.12559 [doi]
AB  - AIM: Early intervention programmes for first episode psychosis (FEP) aim to 
      reduce the duration of untreated psychosis (DUP) and improve functional outcomes. 
      The sustained maintenance of improved outcomes depends largely on patients' 
      adherence to prescribed treatment. This paper examines the prevalence of 
      non-adherence in a cohort of patients with FEP and the sociodemographic and 
      clinical factors associated with non-adherent behaviour. METHODS: The sample 
      included consecutive patients accepted from 2007 to 2012 into the Early Psychosis 
      Intervention Programme (EPIP) in Singapore. Sociodemographic variables as well as 
      DUP, insight, severity of psychopathology and clinical diagnoses were collected. 
      Patients were assessed at baseline and 1 year with the PANSS and Global 
      Assessment of Functioning Scale (GAF). Medication adherence was grouped into 3 
      categories: no-adherence, partial adherence and regular adherence. RESULTS: Of 
      the 445 patients included, 51% were male with a mean age of 26.3 years, 74.6% had 
      schizophrenia spectrum and delusional disorders, 14% had affective psychosis and 
      11.3% had brief psychotic disorder or psychotic disorder not otherwise specified. 
      At 1 year follow up, 65.5% reported regular adherence, 18.7% were partially 
      adherent and 15.8% were non-adherent. Non-adherence was correlated with male 
      gender, living alone and having poorer judgement and insight. Partial adherence 
      was associated with Malay ethnicity and having undergone national service. 
      CONCLUSION: Medication adherence is prevalent in FEP and associated with a 
      variety of factors. This study supports the use of culturally appropriate 
      interventions in addressing barriers to adherence. Further studies would need to 
      be done to address specific factors affecting adherence outcomes.
CI  - (c) 2018 John Wiley & Sons Australia, Ltd.
FAU - Tan, Chunzhen
AU  - Tan C
AD  - Department of Early Psychosis Intervention, Institute of Mental Health, 
      Singapore.
FAU - Abdin, Edimansyah
AU  - Abdin E
AD  - Research Division, Institute of Mental Health, Singapore.
FAU - Liang, Wilfred
AU  - Liang W
AD  - Department of Early Psychosis Intervention, Institute of Mental Health, 
      Singapore.
FAU - Poon, Lye Yin
AU  - Poon LY
AD  - Department of Early Psychosis Intervention, Institute of Mental Health, 
      Singapore.
FAU - Poon, Ngar Yee
AU  - Poon NY
AD  - Department of Early Psychosis Intervention, Institute of Mental Health, 
      Singapore.
FAU - Verma, Swapna
AU  - Verma S
AD  - Department of Early Psychosis Intervention, Institute of Mental Health, 
      Singapore.
LA  - eng
PT  - Journal Article
DEP - 20180309
PL  - Australia
TA  - Early Interv Psychiatry
JT  - Early intervention in psychiatry
JID - 101320027
SB  - IM
MH  - Adult
MH  - Affective Disorders, Psychotic/*psychology
MH  - Early Medical Intervention/statistics & numerical data
MH  - Ethnicity/psychology
MH  - Female
MH  - Humans
MH  - Male
MH  - Medication Adherence/*psychology
MH  - Psychotic Disorders/*psychology
MH  - Schizophrenia, Paranoid/*psychology
MH  - Schizophrenic Psychology
MH  - Singapore
MH  - Young Adult
OTO - NOTNLM
OT  - early intervention
OT  - first-episode psychosis
OT  - medication adherence
EDAT- 2018/03/10 06:00
MHDA- 2019/12/18 06:00
CRDT- 2018/03/10 06:00
PHST- 2017/03/01 00:00 [received]
PHST- 2017/09/02 00:00 [revised]
PHST- 2018/02/04 00:00 [accepted]
PHST- 2018/03/10 06:00 [pubmed]
PHST- 2019/12/18 06:00 [medline]
PHST- 2018/03/10 06:00 [entrez]
AID - 10.1111/eip.12559 [doi]
PST - ppublish
SO  - Early Interv Psychiatry. 2019 Aug;13(4):780-788. doi: 10.1111/eip.12559. Epub 
      2018 Mar 9.