PMID- 29521064
OWN - NLM
STAT- MEDLINE
DCOM- 20190627
LR  - 20190627
IS  - 1899-5276 (Print)
IS  - 1899-5276 (Linking)
VI  - 27
IP  - 2
DP  - 2018 Feb
TI  - The effect of high intensity physical exercise and hypoxia on glycemia, 
      angiogenic biomarkers and cardiorespiratory function in patients with type 1 
      diabetes.
PG  - 207-216
LID - 10.17219/acem/66354 [doi]
AB  - BACKGROUND: An integral part of the treatment of diabetes is physical activity. 
      Scientific reports have shown the beneficial effects of hypoxia and exercise on 
      cardiovascular and metabolic variables in patients with diabetes. OBJECTIVES: The 
      aim of the study was to assess the effect of normobaric hypoxia and exercise on 
      the serum concentrations of proangiogenic factors and glycemia in patients with 
      type 1 diabetes. MATERIAL AND METHODS: A total of 28 adults (aged 30.4 years +/-9.7 
      years), suffering from diabetes for 12.1 years +/-6.0 years and healthy 
      individuals, participated in the following trials: normoxic (Nor) and hypoxic 
      (Hy) rest and Nor and Hy incremental exercise test (Ex) (FIO2 = 15.2%). The 
      Altitude Trainer Hypoxico System (HYP-123 Hypoxic Generator, LOWOXYGEN Technology 
      GmbH, Berlin, Germany) corresponding to a height of about 2500 m above sea level 
      was used in the study. Exercise tests were performed on a cycle ergometer 
      Excalibur Sport (Lode B.V., Groningen, The Netherlands). Cardiorespiratory 
      variables, glycemia, angiogenic and hematological indices were measured at rest 
      and in response to both exercise protocols. RESULTS: The present data confirmed 
      that the patients with type 1 diabetes demonstrated a good level of aerobic 
      capacity and fitness. NorEx and HyEx resulted in a significant decrease in serum 
      glucose concentration (p < 0.05 vs p < 0.01). Patients with diabetes had higher 
      baseline hypoxia induced factor-1alpha levels compared to healthy adults (p < 
      0.05), which increased after exposure to hypoxia and hypoxia with exercise (p < 
      0.001). Hypoxia significantly decreased baseline transforming growth factor-beta 
      (TGF-beta) (p < 0.05) and had a significant effect on tumor necrosis factor-alpha level 
      (TNF-alpha) (F = 4.9; p < 0.05). CONCLUSIONS: Our study demonstrated that hypoxia 
      combined with exercise reduces glycemia and may induce significant benefits in 
      the prevention of diabetes cardiovascular complications.
FAU - Zebrowska, Aleksandra
AU  - Zebrowska A
AD  - Department of Physiological and Medical Sciences, Academy of Physical Education, 
      Katowice, Poland.
FAU - Hall, Barbara
AU  - Hall B
AD  - Department of Physiological and Medical Sciences, Academy of Physical Education, 
      Katowice, Poland.
FAU - Kochanska-Dziurowicz, Aleksandra
AU  - Kochanska-Dziurowicz A
AD  - Department of Health Care, Silesian Medical College, Katowice, Poland.
FAU - Janikowska, Grazyna
AU  - Janikowska G
AD  - Department of Analytical Chemistry, Medical University of Silesia, Katowice, 
      Poland.
LA  - eng
PT  - Journal Article
PL  - Poland
TA  - Adv Clin Exp Med
JT  - Advances in clinical and experimental medicine : official organ Wroclaw Medical 
      University
JID - 101138582
RN  - 0 (Biomarkers)
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Adult
MH  - Biomarkers
MH  - Diabetes Mellitus, Type 1/*therapy
MH  - Exercise/*physiology
MH  - Exercise Test
MH  - Exercise Tolerance/*physiology
MH  - Germany
MH  - Humans
MH  - Hypoxia/*physiopathology
MH  - Oxygen/metabolism
MH  - Physical Fitness
OTO - NOTNLM
OT  - angiogenesis
OT  - exercise tolerance
OT  - hypoxia-inducible factor-1
OT  - type 1 diabetes mellitus
EDAT- 2018/03/10 06:00
MHDA- 2019/06/30 06:00
CRDT- 2018/03/10 06:00
PHST- 2018/03/10 06:00 [entrez]
PHST- 2018/03/10 06:00 [pubmed]
PHST- 2019/06/30 06:00 [medline]
AID - 10.17219/acem/66354 [doi]
PST - ppublish
SO  - Adv Clin Exp Med. 2018 Feb;27(2):207-216. doi: 10.17219/acem/66354.