PMID- 29521164
OWN - NLM
STAT- MEDLINE
DCOM- 20181030
LR  - 20181030
IS  - 1607-8454 (Electronic)
IS  - 1024-5332 (Linking)
VI  - 23
IP  - 9
DP  - 2018 Oct
TI  - Causes of microcytic anaemia and evaluation of conventional laboratory parameters 
      in the differentiation of erythrocytic microcytosis in blood donors candidates.
PG  - 705-711
LID - 10.1080/10245332.2018.1446703 [doi]
AB  - CONTEXT AND OBJECTIVE: Microcytic anaemia results from defective synthesis of 
      haemoglobin in the erythroid precursors, causing a reduction in its mean 
      corpuscular volume (MCV). The most common causes of microcytosis, without the 
      increase in HbA(2) levels, are iron deficiency anaemia (IDA) and alpha-thalassemia. 
      The aim of this study was to identify the causes of microcytic anaemia and 
      evaluate the haematological parameters from blood donors deemed ineligible (due 
      to the low haematocrit level) that would differentiate the IDA and alpha-thal, 
      whether isolated or in association. METHODS: Genomic DNA was submitted to the 
      polymerase chain reaction multiplex for the diagnosis of the most common allele 
      deletions of alpha-thal and erythrogram and in order to verify haematological 
      parameters. Iron deficiency (ID) was determined through the measurement of serum 
      ferritin. RESULTS: Of the 204 samples, 82 (40.2%) were identified with ID, 24 
      (17.8%) with alpha-thal and 10 (4.9%) with ID associated with alpha-thal. In the alpha-thal 
      with ID group haemoglobin (Hb), MCV, mean corpuscular Hb concentration (MCHC) and 
      mean corpuscular Hb (MCH) values were significantly lower compared to the 
      isolated alpha-thal. In the group with ID Hb, MCV, MCHC and MCH values were 
      significantly lower compared to those with isolated alpha-thal. The alpha-thal with ID 
      group, showed Hb, MCV, MCHC and MCH significantly reduced when compared to those 
      with IDA. CONCLUSIONS: This study showed that the values of haematological 
      parameters, especially haematocrit, Hb, MCV, MCH, MCHC and red blood cell 
      distribution width (RDW), are lower in patients with IDA, especially when 
      associated with alpha-thal and therefore it may be useful to discriminate between the 
      different types of microcytic anaemia.
FAU - Carlos, Aline Menezes
AU  - Carlos AM
AD  - a Department of Medicine , Universidade Federal do Triangulo Mineiro (UFTM) , 
      Uberaba , Minas Gerais , Brazil.
FAU - Souza, Bruna Maria Bereta de
AU  - Souza BMB
AD  - a Department of Medicine , Universidade Federal do Triangulo Mineiro (UFTM) , 
      Uberaba , Minas Gerais , Brazil.
FAU - Souza, Renata Andreia Volpe de
AU  - Souza RAV
AD  - a Department of Medicine , Universidade Federal do Triangulo Mineiro (UFTM) , 
      Uberaba , Minas Gerais , Brazil.
FAU - Resende, Glaucia Aparecida Domingos
AU  - Resende GAD
AD  - a Department of Medicine , Universidade Federal do Triangulo Mineiro (UFTM) , 
      Uberaba , Minas Gerais , Brazil.
FAU - Pereira, Gilberto de Araujo
AU  - Pereira GA
AD  - b Department of Nursing , Universidade Federal do Triangulo Mineiro (UFTM) , 
      Uberaba , Minas Gerais , Brazil.
FAU - Moraes-Souza, Helio
AU  - Moraes-Souza H
AD  - c Department of Medicine , Universidade Federal do Triangulo Mineiro (UFTM) , 
      Uberaba , Minas Gerais , Brazil.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Multicenter Study
PT  - Observational Study
DEP - 20180309
PL  - England
TA  - Hematology
JT  - Hematology (Amsterdam, Netherlands)
JID - 9708388
RN  - 9034-53-1 (Hemoglobin A2)
SB  - IM
MH  - Adult
MH  - Anemia/*blood
MH  - *Blood Donors
MH  - *Erythrocyte Indices
MH  - Erythroid Cells/*metabolism/pathology
MH  - Female
MH  - Hematocrit
MH  - Hemoglobin A2/*metabolism
MH  - Humans
MH  - Male
OTO - NOTNLM
OT  - Anaemia
OT  - anaemia
OT  - diagnosis
OT  - differential
OT  - erythrocyte indices
OT  - hypochromic microcytic
OT  - iron deficiency
OT  - thalassemia
EDAT- 2018/03/10 06:00
MHDA- 2018/10/31 06:00
CRDT- 2018/03/10 06:00
PHST- 2018/03/10 06:00 [pubmed]
PHST- 2018/10/31 06:00 [medline]
PHST- 2018/03/10 06:00 [entrez]
AID - 10.1080/10245332.2018.1446703 [doi]
PST - ppublish
SO  - Hematology. 2018 Oct;23(9):705-711. doi: 10.1080/10245332.2018.1446703. Epub 2018 
      Mar 9.