PMID- 29521315
OWN - NLM
STAT- MEDLINE
DCOM- 20190513
LR  - 20190513
IS  - 2149-2271 (Electronic)
IS  - 2149-2263 (Print)
IS  - 2149-2263 (Linking)
VI  - 19
IP  - 3
DP  - 2018 Mar
TI  - Relationship between intrarenal renin-angiotensin activity and re-hospitalization 
      in patients with heart failure with reduced ejection fraction.
PG  - 205-212
LID - 10.14744/AnatolJCardiol.2018.68726 [doi]
AB  - OBJECTIVE: Heart failure (HF) is a clinical syndrome resulting from structural or 
      functional damages. Although clinical trials have shown that the plasma 
      renin-angiotensin system (RAS) activation decreases HF functional status and 
      increases hospitalization for HF patients, the effect of intrarenal RAS activity 
      is still unknown. In this study, we investigated the relationship between the New 
      York Heart Association (NYHA) class, duration, and number of hospitalizations in 
      the previous year and urinary angiotensinogen (UAGT) in patients with HF with 
      reduced ejection fraction (HFrEF). METHODS: This study included 85 patients who 
      had an ejection fraction of <40% and were receiving optimal medical treatment. 
      Among these, 22 were excluded from the study for various reasons. Demographically 
      and biochemically, the remaining 63 patients were compared according to the NYHA 
      functional classes and re-hospitalization status. RESULTS: When the groups were 
      compared in terms of N-terminal pro-B-type natriuretic peptide (NT-proBNP), UAGT, 
      and high-sensitivity C-reactive protein (Hs-CRP), it was found that these 
      parameters were significantly higher in patients who were hospitalized more than 
      two times in the previous year [p<0.001; p=0.007; p<0.001, respectively]. There 
      was a significant correlation between number of hospitalizations and NT-proBNP 
      (r=0.507, p<0.001), Hs-CRP (r=0.511, p<0.001), hemoglobin (r=-0.419, p=0.001), 
      serum sodium (r=-0.26, p=0.04), and systolic blood pressure (r=-0.283, p=0.02). 
      When the independence of multiple correlations was assessed using multiple linear 
      regression analysis, NT-proBNP, Hs-CRP, and hemoglobin levels were independent 
      predictors of re-hospitalization, but this was not the same for UAGT. CONCLUSION: 
      Although UAGT levels are high in patients with poor NYHA functional class and 
      repeated hospitalizations, this marker is not valuable for predicting repeated 
      hospitalization in patients with HFrEF.
FAU - Orscelik, Ozcan
AU  - Orscelik O
AD  - Department of Cardiology, Faculty of Medicine, Mersin University; Mersin-Turkey. 
      ozcanorscelik@yahoo.com.
FAU - Ozkan, Bugra
AU  - Ozkan B
FAU - Arslan, Ayca
AU  - Arslan A
FAU - Sahin, Emre Ertan
AU  - Sahin EE
FAU - Sakarya, Ozan
AU  - Sakarya O
FAU - Surmeli, Orcun Ali
AU  - Surmeli OA
FAU - Balci Fidanci, Senay
AU  - Balci Fidanci S
FAU - Celik, Ahmet
AU  - Celik A
FAU - Cimen, Burak Yavuz
AU  - Cimen BY
FAU - Ozcan, Ismail Turkay
AU  - Ozcan IT
LA  - eng
PT  - Journal Article
PL  - Turkey
TA  - Anatol J Cardiol
JT  - Anatolian journal of cardiology
JID - 101652981
RN  - 0 (Biomarkers)
RN  - 11002-13-4 (Angiotensinogen)
SB  - IM
MH  - Aged
MH  - Angiotensinogen/*urine
MH  - Biomarkers/*urine
MH  - Female
MH  - Heart Failure/complications/mortality/*physiopathology/urine
MH  - Hospitalization
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Renin-Angiotensin System
MH  - Stroke Volume
MH  - Turkey
MH  - Ventricular Dysfunction, Left/complications/mortality/*physiopathology/urine
PMC - PMC5864771
COIS- Conflict of interest: None declared.
EDAT- 2018/03/10 06:00
MHDA- 2019/05/14 06:00
PMCR- 2018/03/01
CRDT- 2018/03/10 06:00
PHST- 2018/03/10 06:00 [entrez]
PHST- 2018/03/10 06:00 [pubmed]
PHST- 2019/05/14 06:00 [medline]
PHST- 2018/03/01 00:00 [pmc-release]
AID - AJC-19-205 [pii]
AID - 10.14744/AnatolJCardiol.2018.68726 [doi]
PST - ppublish
SO  - Anatol J Cardiol. 2018 Mar;19(3):205-212. doi: 
      10.14744/AnatolJCardiol.2018.68726.