PMID- 29521680
OWN - NLM
STAT- MEDLINE
DCOM- 20190207
LR  - 20190215
IS  - 1473-558X (Electronic)
IS  - 0959-4965 (Linking)
VI  - 29
IP  - 6
DP  - 2018 Apr 11
TI  - Leptin in the nucleus accumbens blocks the increase of GluA1 phosphorylation 
      induced by acute cocaine administration.
PG  - 483-487
LID - 10.1097/WNR.0000000000001001 [doi]
AB  - Leptin in the rat's nucleus accumbens (NAcc) core has previously shown to disrupt 
      the effects of acute administration of cocaine on both locomotor activity and the 
      phosphorylation levels of glycogen synthase kinase 3beta. In the present study, we 
      further measured the phosphorylation levels of GluA1 after bilateral 
      microinjections of leptin in this site followed by acute administration of 
      cocaine. Interestingly, leptin in the NAcc core significantly blocks the increase 
      of GluA1 phosphorylation levels at serine 845 induced by acute administration of 
      cocaine. These effects were not observed for GluA1 phosphorylation levels at 
      serine 831. We have also found additional evidence that glycogen synthase kinase 
      3beta may play a major role in mediating these processes.
FAU - Lee, Jung Won
AU  - Lee JW
FAU - Kim, Wha Young
AU  - Kim WY
FAU - Kim, Jeong-Hoon
AU  - Kim JH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Neuroreport
JT  - Neuroreport
JID - 9100935
RN  - 0 (Leptin)
RN  - 0 (Receptors, AMPA)
RN  - 0 (Vasoconstrictor Agents)
RN  - EC 2.7.11.1 (Glycogen Synthase Kinase 3 beta)
RN  - I5Y540LHVR (Cocaine)
RN  - TFZ3H25BS1 (glutamate receptor ionotropic, AMPA 1)
SB  - IM
MH  - Animals
MH  - Cocaine/*administration & dosage
MH  - Glycogen Synthase Kinase 3 beta/metabolism
MH  - Leptin/metabolism/*pharmacology
MH  - Male
MH  - Microinjections
MH  - Nucleus Accumbens/*drug effects/metabolism
MH  - Phosphorylation/drug effects
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, AMPA/*metabolism
MH  - Vasoconstrictor Agents/*administration & dosage
EDAT- 2018/03/10 06:00
MHDA- 2019/02/08 06:00
CRDT- 2018/03/10 06:00
PHST- 2018/03/10 06:00 [pubmed]
PHST- 2019/02/08 06:00 [medline]
PHST- 2018/03/10 06:00 [entrez]
AID - 10.1097/WNR.0000000000001001 [doi]
PST - ppublish
SO  - Neuroreport. 2018 Apr 11;29(6):483-487. doi: 10.1097/WNR.0000000000001001.