PMID- 29522357
OWN - NLM
STAT- MEDLINE
DCOM- 20190215
LR  - 20190503
IS  - 1559-2308 (Electronic)
IS  - 1559-2294 (Print)
IS  - 1559-2294 (Linking)
VI  - 13
IP  - 3
DP  - 2018
TI  - Genipin normalizes depression-like behavior induced by prenatal stress through 
      inhibiting DNMT1.
PG  - 310-317
LID - 10.1080/15592294.2018.1450033 [doi]
AB  - Synthetic antidepressants in current use for the complex etiopathogeneses of 
      depression have slow response and remission as well as various unpleasant side 
      effects. As a result, it is imperative to develop new antidepressants with more 
      effectiveness and less severe side effects. Recent studies demonstrated that 
      genipin, the aglycon of geniposide, extracted from Gardenia jasminoides Ellis has 
      antidepressive effects. However, knowledge regarding the molecular mechanisms of 
      its antidepressant effects remains limited. Employing a depression-like mouse 
      model, we confirmed that genipin is capable of correcting depressions-like 
      behaviors induced by prenatal stress in offspring from prenatally stressed dams 
      (defined as PRS mice). In further experiments, we found that the effect of 
      genipin on PRS mice occurs through DNA demethylation by inhibiting DNA 
      methyltransferase 1 (DNMT1), normalizing the expression of reduced brain-derived 
      neurotrophic factor (BDNF) in the hippocampus.
FAU - Ye, Di
AU  - Ye D
AD  - a Oncology Department, The Second Affiliated Hospital , Chongqing Medical 
      University , Yuzhong District , Chongqing , China.
FAU - Zhang, Li
AU  - Zhang L
AD  - a Oncology Department, The Second Affiliated Hospital , Chongqing Medical 
      University , Yuzhong District , Chongqing , China.
FAU - Fan, Weidong
AU  - Fan W
AD  - a Oncology Department, The Second Affiliated Hospital , Chongqing Medical 
      University , Yuzhong District , Chongqing , China.
FAU - Zhang, Xianquan
AU  - Zhang X
AD  - a Oncology Department, The Second Affiliated Hospital , Chongqing Medical 
      University , Yuzhong District , Chongqing , China.
FAU - Dong, Erbo
AU  - Dong E
AD  - a Oncology Department, The Second Affiliated Hospital , Chongqing Medical 
      University , Yuzhong District , Chongqing , China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180503
PL  - United States
TA  - Epigenetics
JT  - Epigenetics
JID - 101265293
RN  - 0 (Antidepressive Agents)
RN  - 0 (Bdnf protein, mouse)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Iridoids)
RN  - A3V2NE52YG (genipin)
RN  - EC 2.1.1.37 (DNA (Cytosine-5-)-Methyltransferase 1)
RN  - EC 2.1.1.37 (Dnmt1 protein, mouse)
SB  - IM
MH  - Animals
MH  - Antidepressive Agents/administration & dosage
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - DNA (Cytosine-5-)-Methyltransferase 1/*genetics
MH  - DNA Methylation/drug effects/*genetics
MH  - Depression/*drug therapy/genetics/pathology
MH  - Disease Models, Animal
MH  - Female
MH  - Gardenia/chemistry
MH  - Gene Expression Regulation/drug effects
MH  - Hippocampus/drug effects
MH  - Humans
MH  - Iridoids/*administration & dosage/chemistry
MH  - Mice
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/drug therapy/genetics/pathology
MH  - Stress, Psychological/drug therapy/genetics/pathology
PMC - PMC5997145
OTO - NOTNLM
OT  - BDNF
OT  - DNA methylation
OT  - DNMT1
OT  - Genipin
OT  - depression
OT  - mouse
OT  - prenatal stress
EDAT- 2018/03/10 06:00
MHDA- 2019/02/16 06:00
PMCR- 2019/05/03
CRDT- 2018/03/10 06:00
PHST- 2018/03/10 06:00 [pubmed]
PHST- 2019/02/16 06:00 [medline]
PHST- 2018/03/10 06:00 [entrez]
PHST- 2019/05/03 00:00 [pmc-release]
AID - 1450033 [pii]
AID - 10.1080/15592294.2018.1450033 [doi]
PST - ppublish
SO  - Epigenetics. 2018;13(3):310-317. doi: 10.1080/15592294.2018.1450033. Epub 2018 
      May 3.