PMID- 29523413
OWN - NLM
STAT- MEDLINE
DCOM- 20191004
LR  - 20210109
IS  - 1873-2402 (Electronic)
IS  - 0006-3223 (Print)
IS  - 0006-3223 (Linking)
VI  - 84
IP  - 4
DP  - 2018 Aug 15
TI  - Insula-Retrosplenial Cortex Overconnectivity Increases Internalizing via Reduced 
      Insight in Autism.
PG  - 287-294
LID - S0006-3223(18)30063-5 [pii]
LID - 10.1016/j.biopsych.2018.01.015 [doi]
AB  - BACKGROUND: Internalizing symptoms like anxiety and depression are common and 
      impairing in autism spectrum disorder (ASD). Here, we test the hypothesis that 
      aberrant functional connectivity among three brain networks (salience network 
      [SN], default mode network [DMN], and frontoparietal network [FPN]) plays a role 
      in the pathophysiology of internalizing in ASD. METHODS: We examined the 
      association between resting-state functional connectivity and internalizing in 
      102 adolescents and young adults with ASD (n = 49) or typical development (n = 
      53). Seed-to-target functional connectivity was contrasted between adolescents 
      and young adults with ASD and typically developing subjects using a recent 
      parcellation of the human cerebral cortex, and connections that were aberrant in 
      ASD were analyzed dimensionally as a function of parent-reported internalizing 
      symptoms. RESULTS: Three connections demonstrated robust overconnectivity in ASD: 
      1) the anterior insula to the retrosplenial cortex (i.e., SN-DMN), 2) the 
      anterior insula to the frontal pole (i.e., SN-FPN), and 3) the dorsolateral 
      prefrontal cortex to the retrosplenial cortex (i.e., FPN-DMN). These differences 
      remained significant after controlling for age, and no age-related effects 
      survived correction. The SN-DMN connection was associated with greater 
      internalizing in ASD, mediated by a bigger difference between self- and 
      parent-reported internalizing. Control analyses found that the other two 
      connections were not associated with internalizing, and SN-DMN connectivity was 
      not associated with a well-matched control measure (externalizing symptoms). 
      CONCLUSIONS: The present findings provide novel evidence for a specific link 
      between SN-DMN overconnectivity and internalizing in ASD. Further, the mediation 
      results suggest that intact anterior insula-retrosplenial connectivity may play a 
      role in an individual's generating insight into his or her own psychopathology.
CI  - Copyright (c) 2018 Society of Biological Psychiatry. Published by Elsevier Inc. All 
      rights reserved.
FAU - Hogeveen, Jeremy
AU  - Hogeveen J
AD  - MIND Institute, University of California, Davis, Sacramento, California; 
      Department of Psychiatry and Behavioral Sciences, University of California, 
      Davis, Sacramento, California. Electronic address: hogeveen@ucdavis.edu.
FAU - Krug, Marie K
AU  - Krug MK
AD  - MIND Institute, University of California, Davis, Sacramento, California; 
      Department of Psychiatry and Behavioral Sciences, University of California, 
      Davis, Sacramento, California.
FAU - Elliott, Matthew V
AU  - Elliott MV
AD  - MIND Institute, University of California, Davis, Sacramento, California; 
      Department of Psychiatry and Behavioral Sciences, University of California, 
      Davis, Sacramento, California.
FAU - Solomon, Marjorie
AU  - Solomon M
AD  - MIND Institute, University of California, Davis, Sacramento, California; 
      Department of Psychiatry and Behavioral Sciences, University of California, 
      Davis, Sacramento, California; Imaging Research Center, University of California, 
      Davis, Sacramento, California.
LA  - eng
GR  - R01 MH106518/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20180131
PL  - United States
TA  - Biol Psychiatry
JT  - Biological psychiatry
JID - 0213264
SB  - IM
CIN - Biol Psychiatry. 2018 Aug 15;84(4):236-238. PMID: 30071947
MH  - Adolescent
MH  - Anxiety Disorders/physiopathology
MH  - Attention Deficit Disorder with Hyperactivity/physiopathology
MH  - Autism Spectrum Disorder/*physiopathology
MH  - Cerebral Cortex/*physiopathology
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Neural Pathways/*physiopathology
MH  - Reproducibility of Results
MH  - Young Adult
PMC - PMC6067993
MID - NIHMS938247
OTO - NOTNLM
OT  - Anterior insula
OT  - Anxiety
OT  - Autism spectrum disorder
OT  - Internalizing
OT  - Retrosplenial cortex
OT  - Salience network
EDAT- 2018/03/11 06:00
MHDA- 2019/10/08 06:00
PMCR- 2019/08/15
CRDT- 2018/03/11 06:00
PHST- 2017/11/01 00:00 [received]
PHST- 2018/01/14 00:00 [revised]
PHST- 2018/01/16 00:00 [accepted]
PHST- 2018/03/11 06:00 [pubmed]
PHST- 2019/10/08 06:00 [medline]
PHST- 2018/03/11 06:00 [entrez]
PHST- 2019/08/15 00:00 [pmc-release]
AID - S0006-3223(18)30063-5 [pii]
AID - 10.1016/j.biopsych.2018.01.015 [doi]
PST - ppublish
SO  - Biol Psychiatry. 2018 Aug 15;84(4):287-294. doi: 10.1016/j.biopsych.2018.01.015. 
      Epub 2018 Jan 31.