PMID- 29523823
OWN - NLM
STAT- MEDLINE
DCOM- 20190918
LR  - 20190918
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 8
IP  - 1
DP  - 2018 Mar 9
TI  - Evaluation of the therapeutic effects of QuickOpt optimization in Chinese 
      patients with chronic heart failure treated by cardiac resynchronization.
PG  - 4259
LID - 10.1038/s41598-018-22525-0 [doi]
LID - 4259
AB  - In this trial, long-term therapeutic effects and clinical improvements in Chinese 
      chronic heart failure patients optimized by QuickOpt or echocardiography were 
      compared for atrioventricular (AV) and interventricular (VV) delay optimizations 
      after cardiac resynchronization therapy (CRT) with pacing (CRT-P) or with pacing 
      and defibrillator (CRT-D) therapy. One hundred and ninety-six subjects (50%) had 
      dilated cardiomyopathy, 108 (27.6%) had ischemic heart disease and 112 (28.6%) 
      were hypertensive and were randomized into QuickOpt (198) or echocardiographic 
      optimization (control) (194) groups at </=2-weeks post-implantation. Programmed 
      AV/VV delay was optimized at baseline and at 3 and 6 months. Left ventricular 
      end-systolic volume (LVESV), New York Heart Association (NYHA) class, specific 
      activity scale (SAS), and the six-minute walk tests (6MWT) were evaluated by 
      blinded researchers at 12 months. Of the QuickOpt group, LVESV decreased 
      significantly by 24.7% +/- 33.9% compared with baseline, while LVESV of Controls 
      decreased by 25.1% +/- 36.1% (P = 0.924). NYHA class, SAS and 6MWT also improved 
      similarly in both groups at 12 months. Mortality in both groups was not 
      significantly different (11.0% vs 7.6%, P = 0.289). However, there was a 
      significant difference in the time required for optimization by QuickOpt compared 
      with echocardiography (3.33 +/- 3.11 vs 58.79 +/- 27.03 minutes, P < 0.000).
FAU - Yan, Ji
AU  - Yan J
AD  - Department of Cardiology, Anhui Provincial Hospital, No. 17 Lujiang Road, Hefei, 
      230001, China.
FAU - Zhang, Shu
AU  - Zhang S
AD  - Cardiac Arrhythmia center, Fuwai Hospital, Chinese Academy of medical Sciences, 
      No. 167 North Lishi Road, Beijing, 100037, China. ZhangShu021617@163.com.
FAU - Huang, Dejia
AU  - Huang D
AD  - Department of Cardiology, West China Hospital, Sichuan University, No. 37 Guoxue 
      lane, Chengdu, 610041, China. HuangDejia021617@163.com.
FAU - Xue, Xiaolin
AU  - Xue X
AD  - Department of Cardiology, The First Affiliated Hospital of Xi'an Jiaotong 
      University, No. 277 Yanta West Road, Xi'an, 710061, China.
FAU - Xu, Jing
AU  - Xu J
AD  - Department of Cardiology, Tianjin chest hospital, No. 93 Xi'an Road, Tianjin, 
      300051, China.
FAU - Tao, Qianmin
AU  - Tao Q
AD  - Department of Cardiology, The First Affiliated Hospital, Zhejiang University, No. 
      79 Qingchun Road, Hangzhou, 310003, China.
FAU - Zhang, Weize
AU  - Zhang W
AD  - Department of Cardiology, The General Hospital of Lanzhou Military, No. 98 
      Xiaoxihu West Street, Lanzhou, 730050, China.
FAU - Zhang, Zheng
AU  - Zhang Z
AD  - Department of Cardiology, The First Hospital of Lanzhou University, No. 1 
      Donggang West Road, Lanzhou, 730000, China.
FAU - Hua, Wei
AU  - Hua W
AD  - Cardiac Arrhythmia center, Fuwai Hospital, Chinese Academy of medical Sciences, 
      No. 167 North Lishi Road, Beijing, 100037, China.
FAU - Liang, Yanchun
AU  - Liang Y
AD  - Department of Cardiology, The General Hospital of Shenyang Military, No. 83 
      Wenhua Road, Shenyang, 110840, China.
FAU - Tang, Baopeng
AU  - Tang B
AD  - Department of Cardiology, The First Affiliated Hospital of Xinjiang Medical 
      University, No. 137 Liyushan South Road, Urumqi, 830054, China.
FAU - Xu, Wei
AU  - Xu W
AD  - Department of Cardiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of 
      Nanjing University Medical School, No. 321 Zhongshan Road, Nanjing, 210008, 
      China.
FAU - Xu, Geng
AU  - Xu G
AD  - Department of Cardiology, The Second Affiliated Hospital of Zhejiang University 
      School of Medicine, No. 88 Jiefang Road, Hangzhou, 310009, China.
FAU - Ren, Xuejun
AU  - Ren X
AD  - Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, 
      No. 2 Anzhen Road, Beijing, 100029, China.
FAU - Wang, Jingfeng
AU  - Wang J
AD  - Department of Cardiology, Sun Yat-sen Memorial Hospital of Sun Yat-sen 
      University, No. 107 Yanjiang West Road, Guangzhou, 510120, China.
FAU - Guo, Tao
AU  - Guo T
AD  - Department of Cardiology, The First Affiliated Hospital of Kunming Medical 
      University, No. 295 Xichang Road, Kunming, 650032, China.
FAU - Jia, Shaobin
AU  - Jia S
AD  - Department of Cardiology, General Hospital of Ningxia Medical University, No. 804 
      Shengli South Street, Yinchuan, 750004, China.
FAU - Dong, Yugang
AU  - Dong Y
AD  - Department of Cardiology, The First Affiliated Hospital of Sun Yat-sen 
      University, No. 58 Zhongshan Er Road, Guangzhou, 510080, China.
FAU - Jiang, Hong
AU  - Jiang H
AD  - Department of Cardiology, Renmin Hospital of Wuhan University, No. 99 
      Zhangzhidong Road, Wuhan, 430060, China.
FAU - Fu, Guosheng
AU  - Fu G
AD  - Department of Cardiology, Sir Run Run Shaw Hospital of Medicine, Zhejiang 
      University, No. 3 Qingchun East Road, Hangzhou, 310020, China.
FAU - Zhu, Liguang
AU  - Zhu L
AD  - Department of Cardiology, The First Affiliated Hospital of Guangxi Medical 
      University, No. 6 Shuangyong Road, Nanjing, 530021, China.
FAU - Chen, Lin
AU  - Chen L
AD  - Department of Cardiology, Fujian Provincial Hospital, No. 134 East Street, 
      Fuzhou, 350001, China.
FAU - Tian, Fuli
AU  - Tian F
AD  - The First Department of Cardiology, The 251ST Hospital of PLA, No. 13 Jianguo 
      Road, Zhangjiakou, 075000, China.
FAU - Ling, Feng
AU  - Ling F
AD  - Department of Cardiology, Hangzhou First People's Hospital, No. 261 HuanSha Road, 
      Hangzhou, 310006, China.
FAU - Li, Jianmei
AU  - Li J
AD  - Department of Cardiology, The second people's Hospital of Yunnan Province, No. 
      176 Qingnian Road, Kunming, 650021, China.
FAU - Qi, Xiaoyong
AU  - Qi X
AD  - Department of Cardiology, Hebei General Hospital, No. 348 Heping West Road, 
      Shijiazhuang, 050051, China.
FAU - Hao, Yinglu
AU  - Hao Y
AD  - Department of Cardiology, People's Hospital of Yuxi City, No. 21 Nieer Road, 
      Yuxi, 653100, China.
FAU - Wang, Yutang
AU  - Wang Y
AD  - Department of Cardiology, Chinese PLA General Hospital, No. 28 Fuxing Road, 
      Beijing, 100853, China.
FAU - Zheng, Liangrong
AU  - Zheng L
AD  - Department of Cardiology, The First Affiliated Hospital, Zhejiang University, No. 
      79 Qingchun Road, Hangzhou, 310003, China.
FAU - Pu, Xiaoqun
AU  - Pu X
AD  - Department of Cardiology, Xiangya Hospital Central South University, No. 87 
      xiangya Road, Changsha, 410008, China.
FAU - Shen, Farong
AU  - Shen F
AD  - Department of Cardiology, Zhejiang Greentown Hospital, No. 409 Gudun Road, 
      Hangzhou, 310000, China.
FAU - Li, Guangping
AU  - Li G
AD  - Department of Cardiology, The Second Hospital of Tianjin Medical University, No. 
      23 Pingjiang Road, Tianjin, 300211, China.
FAU - Li, Hui
AU  - Li H
AD  - Department of Cardiology, Daqing Oilfield General Hospital, No. 9 Zhongkang 
      Street, Daqing, 163000, China.
FAU - Peng, Fang
AU  - Peng F
AD  - Department of Cardiology, Shaoxing People's Hospital, No. 568 Zhongxing North 
      Road, Shaoxing, 312000, China.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20180309
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
SB  - IM
MH  - Aged
MH  - Algorithms
MH  - Cardiac Resynchronization Therapy/adverse effects/*methods
MH  - Echocardiography/adverse effects/methods
MH  - Electrocardiography/adverse effects/*methods
MH  - Female
MH  - Heart Failure/diagnosis/*therapy
MH  - Humans
MH  - Male
MH  - Middle Aged
PMC - PMC5844885
COIS- The authors declare no competing interests.
EDAT- 2018/03/11 06:00
MHDA- 2019/09/19 06:00
PMCR- 2018/03/09
CRDT- 2018/03/11 06:00
PHST- 2017/05/05 00:00 [received]
PHST- 2018/02/19 00:00 [accepted]
PHST- 2018/03/11 06:00 [entrez]
PHST- 2018/03/11 06:00 [pubmed]
PHST- 2019/09/19 06:00 [medline]
PHST- 2018/03/09 00:00 [pmc-release]
AID - 10.1038/s41598-018-22525-0 [pii]
AID - 22525 [pii]
AID - 10.1038/s41598-018-22525-0 [doi]
PST - epublish
SO  - Sci Rep. 2018 Mar 9;8(1):4259. doi: 10.1038/s41598-018-22525-0.