PMID- 29523993
OWN - NLM
STAT- MEDLINE
DCOM- 20180717
LR  - 20181114
IS  - 1435-702X (Electronic)
IS  - 0721-832X (Linking)
VI  - 256
IP  - 7
DP  - 2018 Jul
TI  - Structural changes of macular inner retinal layers in early normal-tension and 
      high-tension glaucoma by spectral-domain optical coherence tomography.
PG  - 1245-1256
LID - 10.1007/s00417-018-3944-6 [doi]
AB  - PURPOSE: Assessment of the diagnostic ability of segmented macular inner retinal 
      layer thickness and peripapillary retinal nerve fiber layer (pRNFL) measured by 
      spectral-domain optical coherence tomography (SD-OCT) in patients with 
      normal-tension (NT) and high-tension (HT) perimetric and preperimetric glaucoma. 
      METHODS: The 212 participants included 45 healthy subjects, 55 patients with 
      ocular hypertension, 56 patients with preperimetric glaucoma, and 56 patients 
      with perimetric glaucoma. The preperimetric and perimetric groups were further 
      subdivided into NT and HT groups. Sectoral and global thickness of macular 
      retinal nerve fiber layer (mRNFL), ganglion cell layer (mGCL), inner plexiform 
      layer (mIPL), ganglion cell complex (mGCC), and pRNFL were measured using SD-OCT 
      (Spectralis, Heidelberg Engineering, Germany). Diagnostic performance was 
      ascertained by sectoral and global comparison of the sensitivities at specificity 
      >/= 95%. RESULTS: For all layers, the largest thickness decrease was reported in 
      the HT perimetric group. In all groups, the sensitivities of mGCL showed a 
      comparable diagnostic value to pRNFL in order to distinguish between healthy 
      subjects and glaucoma patients. In the perimetric group, mGCL (85.7%) exhibited 
      higher sensitivities than mRNFL (78.6%) and mGCC (78.6%). Both mRNFL and pRNFL 
      demonstrated equal diagnostic performance in the HT perimetric group (88.5 and 
      96.2%), in the NT groups, mRNFL was inferior to all other layers. CONCLUSION: The 
      sensitivities of mGCL and mRNFL were comparable to the sensitivities of pRNFL. In 
      clinical application, mGCL and mRNFL, with a focus on the temporal and inferior 
      sectors, may provide a convincing supplementation to pRNFL. CLINICAL TRIAL 
      REGISTRATION: Erlangen Glaucoma Registry www.clinicaltrials.gov ID: NCT00494923.
FAU - Edlinger, Florian S M
AU  - Edlinger FSM
AD  - Department of Ophthalmology, University of Erlangen-Nuremberg, Schwabachanlage 6, 
      91054, Erlangen, Germany.
FAU - Schrems-Hoesl, Laura M
AU  - Schrems-Hoesl LM
AD  - Department of Ophthalmology, University of Erlangen-Nuremberg, Schwabachanlage 6, 
      91054, Erlangen, Germany.
FAU - Mardin, Christian Y
AU  - Mardin CY
AD  - Department of Ophthalmology, University of Erlangen-Nuremberg, Schwabachanlage 6, 
      91054, Erlangen, Germany.
FAU - Laemmer, Robert
AU  - Laemmer R
AD  - Department of Ophthalmology, University of Erlangen-Nuremberg, Schwabachanlage 6, 
      91054, Erlangen, Germany.
FAU - Kruse, Friedrich E
AU  - Kruse FE
AD  - Department of Ophthalmology, University of Erlangen-Nuremberg, Schwabachanlage 6, 
      91054, Erlangen, Germany.
FAU - Schrems, Wolfgang A
AU  - Schrems WA
AD  - Department of Ophthalmology, University of Erlangen-Nuremberg, Schwabachanlage 6, 
      91054, Erlangen, Germany. wolfgang.schrems@gmail.com.
LA  - eng
SI  - ClinicalTrials.gov/NCT00494923
PT  - Journal Article
DEP - 20180309
PL  - Germany
TA  - Graefes Arch Clin Exp Ophthalmol
JT  - Graefe's archive for clinical and experimental ophthalmology = Albrecht von 
      Graefes Archiv fur klinische und experimentelle Ophthalmologie
JID - 8205248
SB  - IM
MH  - Disease Progression
MH  - Female
MH  - Fluorescein Angiography/*methods
MH  - Fundus Oculi
MH  - Glaucoma, Open-Angle/*diagnosis/physiopathology
MH  - Humans
MH  - *Intraocular Pressure
MH  - Macula Lutea/pathology
MH  - Male
MH  - Middle Aged
MH  - Nerve Fibers/pathology
MH  - Ocular Hypertension/*diagnosis/physiopathology
MH  - Optic Disk/pathology
MH  - ROC Curve
MH  - Retinal Ganglion Cells/*pathology
MH  - Retinal Photoreceptor Cell Inner Segment/*pathology
MH  - Time Factors
MH  - Tomography, Optical Coherence/*methods
OTO - NOTNLM
OT  - Macular inner retinal layers
OT  - Normal-tension and high-tension glaucoma
OT  - Open angle glaucoma
OT  - Peripapillary retinal nerve fiber layer
OT  - Spectral-domain optical coherence tomography
EDAT- 2018/03/11 06:00
MHDA- 2018/07/18 06:00
CRDT- 2018/03/11 06:00
PHST- 2017/11/27 00:00 [received]
PHST- 2018/02/27 00:00 [accepted]
PHST- 2018/02/21 00:00 [revised]
PHST- 2018/03/11 06:00 [pubmed]
PHST- 2018/07/18 06:00 [medline]
PHST- 2018/03/11 06:00 [entrez]
AID - 10.1007/s00417-018-3944-6 [pii]
AID - 10.1007/s00417-018-3944-6 [doi]
PST - ppublish
SO  - Graefes Arch Clin Exp Ophthalmol. 2018 Jul;256(7):1245-1256. doi: 
      10.1007/s00417-018-3944-6. Epub 2018 Mar 9.