PMID- 29524195
OWN - NLM
STAT- MEDLINE
DCOM- 20181224
LR  - 20210624
IS  - 1559-0720 (Electronic)
IS  - 0163-4984 (Linking)
VI  - 186
IP  - 1
DP  - 2018 Nov
TI  - Maternal Selenium Supplementation Enhanced Skeletal Muscle Development Through 
      Increasing Protein Synthesis and SelW mRNA Levels of their Offspring.
PG  - 238-248
LID - 10.1007/s12011-018-1288-z [doi]
AB  - The present study aimed to investigate the influence of maternal selenium 
      supplementation on the skeletal muscle development of the offspring. A total of 
      720 Ross 308 broiler breeders at 24-week-old were allocated into 3 treatments 
      with 6 replicates of 40 hens each and fed with 0 mg/kg-(group Se/C), 0.5 mg/kg 
      organic-(group Se/O), and 0.5 mg/kg inorganic-(group Se/I) selenium, respectively 
      for 8 weeks. The male offspring from each nutritional treatment were divided and 
      housed into 8 cages of 12 birds each and fed with a commercial diet supplemented 
      with selenium from Na(2)SeO(3) at 0.15 mg/kg. Results showed that Se/O group had 
      the highest selenium deposition (P < 0.05) in the egg yolk and albumen. 
      Furthermore, maternal selenium supplementation promoted breast muscle yield; 
      increased serum insulin and IGF-I concentration; upregulated AKT, mammalian 
      target of rapamycin (mTOR), P70S6K, Myf5, MyoD, MyoG, and SelW mRNA levels; and 
      improved the phosphorylation of AKT at Serine 473 residue, mTOR at Serine 2448 
      residue, and FOXO at Serine 256 residue in skeletal muscles of the offspring. In 
      contrast, the hens' diet supplemented with selenium could result in reduction of 
      uric acid level in serum and downregulation of Atrogin-1 and MuRF1 mRNA levels in 
      the skeletal muscle of the offspring. Additionally, no significant effect on the 
      skeletal muscle development post-hatch was observed between organic and inorganic 
      selenium supplementation. In conclusion, maternal organic selenium 
      supplementation improved selenium deposition in egg; however, no significant 
      effect has been detected on the breast muscle development of the offspring of 
      broiler breeder compared with inorganic selenium supplementation.
FAU - Gao, Jing
AU  - Gao J
AD  - State Key Laboratory of Animal Nutrition, College of Animal Science and 
      Technology, China Agricultural University, No. 2 Yuanmingyuan West Road, Haidian 
      District, Beijing, 100193, China.
FAU - Nie, Wei
AU  - Nie W
AUID- ORCID: 0000-0002-5753-9184
AD  - State Key Laboratory of Animal Nutrition, College of Animal Science and 
      Technology, China Agricultural University, No. 2 Yuanmingyuan West Road, Haidian 
      District, Beijing, 100193, China. caunw@163.com.
FAU - Wang, Fenglai
AU  - Wang F
AD  - State Key Laboratory of Animal Nutrition, College of Animal Science and 
      Technology, China Agricultural University, No. 2 Yuanmingyuan West Road, Haidian 
      District, Beijing, 100193, China.
FAU - Guo, Yuming
AU  - Guo Y
AD  - State Key Laboratory of Animal Nutrition, College of Animal Science and 
      Technology, China Agricultural University, No. 2 Yuanmingyuan West Road, Haidian 
      District, Beijing, 100193, China.
LA  - eng
GR  - CARS-42-G13/China Agriculture Research System program/
PT  - Journal Article
DEP - 20180309
PL  - United States
TA  - Biol Trace Elem Res
JT  - Biological trace element research
JID - 7911509
RN  - 0 (RNA, Messenger)
RN  - 0 (Selenoprotein W)
RN  - H6241UJ22B (Selenium)
SB  - IM
MH  - Animals
MH  - Chickens
MH  - Dietary Supplements
MH  - Dose-Response Relationship, Drug
MH  - Male
MH  - Muscle, Skeletal/*drug effects/metabolism
MH  - Protein Biosynthesis
MH  - RNA, Messenger/*biosynthesis
MH  - Selenium/administration & dosage/*pharmacology
MH  - Selenoprotein W/*biosynthesis
OTO - NOTNLM
OT  - Inorganic selenium
OT  - Offspring
OT  - Organic selenium
OT  - Protein metabolism
OT  - Skeletal muscle
EDAT- 2018/03/11 06:00
MHDA- 2018/12/26 06:00
CRDT- 2018/03/11 06:00
PHST- 2017/11/29 00:00 [received]
PHST- 2018/02/26 00:00 [accepted]
PHST- 2018/03/11 06:00 [pubmed]
PHST- 2018/12/26 06:00 [medline]
PHST- 2018/03/11 06:00 [entrez]
AID - 10.1007/s12011-018-1288-z [pii]
AID - 10.1007/s12011-018-1288-z [doi]
PST - ppublish
SO  - Biol Trace Elem Res. 2018 Nov;186(1):238-248. doi: 10.1007/s12011-018-1288-z. 
      Epub 2018 Mar 9.