PMID- 29524423
OWN - NLM
STAT- MEDLINE
DCOM- 20180509
LR  - 20201209
IS  - 1090-2104 (Electronic)
IS  - 0006-291X (Linking)
VI  - 498
IP  - 4
DP  - 2018 Apr 15
TI  - The suppressive effect of puerarin on atopic dermatitis-like skin lesions through 
      regulation of inflammatory mediators in vitro and in vivo.
PG  - 707-714
LID - S0006-291X(18)30493-5 [pii]
LID - 10.1016/j.bbrc.2018.03.018 [doi]
AB  - Atopic dermatitis (AD) is one of the common inflammatory immune disorders. 
      Puerarin is the main isoflavonoid obtained from the root of Pueraria lobata and 
      has been known have ameliorative effects on diverse inflammatory diseases. 
      However, the effects of puerarin on AD have not been uncovered. 
      2,4-dinitrochlorobenzene (DNCB) was used to induce atopic dermatitis(AD)-like 
      skin lesions on BALB/c mice for 17 days. Further, the BALB/c mice were orally 
      administered puerarin. Puerarin ameliorated DNCB-induced AD-like symptoms in the 
      mice by regulating skin thickness, degranulation of mast cells, and serum 
      immunoglobulin E (IgE). Human keratinocytes (HaCaT cells) were also used to 
      clarify the effects of puerarin on the secretion of pro-inflammatory cytokines. 
      Puerarin inhibited the secretion of inflammatory cytokines and chemokines. The 
      aim of this study was to investigate the protective and alleviative effect of 
      puerarin on AD in vitro and in vivo. The results in this study indicated that 
      puerarin ameliorates AD-like skin lesion and skin inflammation via regulation of 
      various atopic and inflammatory mediators. Therefore, puerarin might be useful in 
      treating AD and other skin diseases.
CI  - Copyright (c) 2018 Elsevier Inc. All rights reserved.
FAU - Lee, Ji-Hyun
AU  - Lee JH
AD  - Department of Immunology and Institute for Medical Sciences, Chonbuk National 
      University Medical School, Jeonju, Jeollabuk-do 54907, Republic of Korea.
FAU - Jeon, Yong-Deok
AU  - Jeon YD
AD  - Department of Oriental Medicine Resources, Chonbuk National University, Iksan, 
      Jeollabuk-do 54596, Republic of Korea.
FAU - Lee, Young-Mi
AU  - Lee YM
AD  - Department of Oriental Pharmacy, College of Pharmacy and Wonkwang-Oriental 
      Medicines Research Institute, Wonkwang University, Iksan, Jeonbuk, 54538, 
      Republic of Korea.
FAU - Kim, Dae-Ki
AU  - Kim DK
AD  - Department of Immunology and Institute for Medical Sciences, Chonbuk National 
      University Medical School, Jeonju, Jeollabuk-do 54907, Republic of Korea. 
      Electronic address: daekim@jbnu.ac.kr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180309
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Cytokines)
RN  - 0 (Dinitrochlorobenzene)
RN  - 0 (Isoflavones)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - Z9W8997416 (puerarin)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents/*therapeutic use
MH  - Cell Line
MH  - Cytokines/analysis/immunology
MH  - Dermatitis, Atopic/chemically induced/*drug therapy/immunology/pathology
MH  - Dinitrochlorobenzene
MH  - Humans
MH  - Isoflavones/*therapeutic use
MH  - Keratinocytes/*drug effects/immunology/pathology
MH  - Male
MH  - Mice, Inbred BALB C
MH  - Skin/*drug effects/immunology/pathology
MH  - Tumor Necrosis Factor-alpha/analysis/immunology
OTO - NOTNLM
OT  - 2,4-dinitrochlorobenzene
OT  - Atopic dermatitis
OT  - Inflammation
OT  - Puerarin
EDAT- 2018/03/11 06:00
MHDA- 2018/05/10 06:00
CRDT- 2018/03/11 06:00
PHST- 2018/02/23 00:00 [received]
PHST- 2018/03/05 00:00 [accepted]
PHST- 2018/03/11 06:00 [pubmed]
PHST- 2018/05/10 06:00 [medline]
PHST- 2018/03/11 06:00 [entrez]
AID - S0006-291X(18)30493-5 [pii]
AID - 10.1016/j.bbrc.2018.03.018 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 2018 Apr 15;498(4):707-714. doi: 
      10.1016/j.bbrc.2018.03.018. Epub 2018 Mar 9.