PMID- 29524513
OWN - NLM
STAT- MEDLINE
DCOM- 20190214
LR  - 20190215
IS  - 1878-4216 (Electronic)
IS  - 0278-5846 (Linking)
VI  - 84
IP  - Pt A
DP  - 2018 Jun 8
TI  - Central irisin administration affords antidepressant-like effect and modulates 
      neuroplasticity-related genes in the hippocampus and prefrontal cortex of mice.
PG  - 294-303
LID - S0278-5846(17)30825-4 [pii]
LID - 10.1016/j.pnpbp.2018.03.004 [doi]
AB  - Evidence has indicated that the practice of physical exercise has antidepressant 
      effects that might be associated with irisin release and BDNF signaling. In this 
      study we investigated the effects of the central administration of irisin or BDNF 
      in predictive tests of antidepressant properties paralleled with the gene 
      expression of peroxisome proliferator-activated receptor gamma co-activator 1alpha 
      (PGC-1alpha), fibronectin type III domain-containing protein 5 (FNDC5) and 
      brain-derived neurotrophic factor (BDNF) in the hippocampus and prefrontal cortex 
      of mice. Irisin (0.5-1 ng/mouse, i.c.v.) reduced the immobility time in the tail 
      suspension test (TST) and forced swim test (FST), without altering locomotion in 
      the open field test (OFT). Irisin reduced the immobility time in the TST up to 
      6 h after its administration. Irisin administration (6 h) increased PGC-1alpha mRNA 
      in the hippocampus and prefrontal cortex and reduced (1 h) PGC-1alpha mRNA in the 
      prefrontal cortex. FNDC5 and BDNF mRNA expression was decreased (1 h) in both 
      structures and remained reduced up to 6 h in the prefrontal cortex. Moreover, 
      BDNF administered at 0.25 mug/mouse, i.c.v. (1 and 6 h before the test) reduced 
      the immobility time in the TST. BDNF administration reduced PGC-1alpha mRNA in the 
      hippocampus (6 h) and prefrontal cortex (1 and 6 h). It also increased FNDC5 mRNA 
      expression in the hippocampus (1 and 6 h), but reduced the expression of this 
      gene and also BDNF mRNA in the prefrontal cortex (1 and 6 h). None of the 
      treatments altered BDNF protein levels in both structures. In conclusion, irisin 
      presents a behavioral antidepressant profile similar to BDNF, an effect 
      associated with the modulation of gene expression of PGC-1alpha, FNDC5 and BDNF, 
      reinforcing the pivotal role of these genes in mood regulation.
CI  - Copyright (c) 2018 Elsevier Inc. All rights reserved.
FAU - Siteneski, Aline
AU  - Siteneski A
AD  - Department of Biochemistry, Center of Biological Sciences, Federal University of 
      Santa Catarina, 88040-900 Florianopolis, SC, Brazil.
FAU - Cunha, Mauricio P
AU  - Cunha MP
AD  - Department of Biochemistry, Center of Biological Sciences, Federal University of 
      Santa Catarina, 88040-900 Florianopolis, SC, Brazil.
FAU - Lieberknecht, Vicente
AU  - Lieberknecht V
AD  - Department of Biochemistry, Center of Biological Sciences, Federal University of 
      Santa Catarina, 88040-900 Florianopolis, SC, Brazil.
FAU - Pazini, Francis L
AU  - Pazini FL
AD  - Department of Biochemistry, Center of Biological Sciences, Federal University of 
      Santa Catarina, 88040-900 Florianopolis, SC, Brazil.
FAU - Gruhn, Karen
AU  - Gruhn K
AD  - Department of Biochemistry, Center of Biological Sciences, Federal University of 
      Santa Catarina, 88040-900 Florianopolis, SC, Brazil.
FAU - Brocardo, Patricia S
AU  - Brocardo PS
AD  - Department of Morphological Sciences, Center of Biological Sciences, Federal 
      University of Santa Catarina, 88040-900 Florianopolis, SC, Brazil.
FAU - Rodrigues, Ana Lucia S
AU  - Rodrigues ALS
AD  - Department of Biochemistry, Center of Biological Sciences, Federal University of 
      Santa Catarina, 88040-900 Florianopolis, SC, Brazil. Electronic address: 
      alsrodri@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180307
PL  - England
TA  - Prog Neuropsychopharmacol Biol Psychiatry
JT  - Progress in neuro-psychopharmacology & biological psychiatry
JID - 8211617
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (FNDC5 protein, human)
RN  - 0 (FNDC5 protein, mouse)
RN  - 0 (Fibronectins)
RN  - 0 (Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha)
RN  - 0 (Ppargc1a protein, mouse)
RN  - 0 (RNA, Messenger)
RN  - 0 (Recombinant Proteins)
SB  - IM
MH  - Animals
MH  - Antidepressive Agents/*administration & dosage
MH  - Brain-Derived Neurotrophic Factor/administration & dosage/metabolism
MH  - Depression/drug therapy/metabolism
MH  - Dose-Response Relationship, Drug
MH  - Fibronectins/*administration & dosage/metabolism
MH  - Gene Expression/drug effects
MH  - Hippocampus/*drug effects/*metabolism
MH  - Humans
MH  - Male
MH  - Mice, Inbred C57BL
MH  - Neuronal Plasticity/drug effects/physiology
MH  - Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/metabolism
MH  - Prefrontal Cortex/*drug effects/*metabolism
MH  - RNA, Messenger/metabolism
MH  - Recombinant Proteins/administration & dosage
OTO - NOTNLM
OT  - Antidepressant
OT  - BDNF
OT  - FNDC5
OT  - Irisin
OT  - PGC-1alpha
EDAT- 2018/03/11 06:00
MHDA- 2019/02/15 06:00
CRDT- 2018/03/11 06:00
PHST- 2017/09/27 00:00 [received]
PHST- 2018/02/13 00:00 [revised]
PHST- 2018/03/06 00:00 [accepted]
PHST- 2018/03/11 06:00 [pubmed]
PHST- 2019/02/15 06:00 [medline]
PHST- 2018/03/11 06:00 [entrez]
AID - S0278-5846(17)30825-4 [pii]
AID - 10.1016/j.pnpbp.2018.03.004 [doi]
PST - ppublish
SO  - Prog Neuropsychopharmacol Biol Psychiatry. 2018 Jun 8;84(Pt A):294-303. doi: 
      10.1016/j.pnpbp.2018.03.004. Epub 2018 Mar 7.