PMID- 29524881
OWN - NLM
STAT- MEDLINE
DCOM- 20180924
LR  - 20181202
IS  - 1950-6007 (Electronic)
IS  - 0753-3322 (Linking)
VI  - 101
DP  - 2018 May
TI  - Human umbilical cord mesenchymal stem cells improve irradiation-induced skin 
      ulcers healing of rat models.
PG  - 729-736
LID - S0753-3322(17)36200-5 [pii]
LID - 10.1016/j.biopha.2018.02.093 [doi]
AB  - Irradiation-induced skin ulcers can be resultant from nuclear accident or 
      reaction to radiation therapy of tumor and is intractable for healing. Human 
      umbilical cord mesenchymal stem cells (hUC-MSCs) have been considered to be the 
      potential therapeutic tools for tissue regeneration. However, the underlying 
      mechanisms are still not well understood. This study aims to investigate the 
      effects of hUC-MSCs on irradiation-induced skin ulcers healing and the related 
      mechanisms. The ulcers were induced by irradiating the skin of adult SD rats. The 
      ulcers of SD rats were treated with vehicle or hUC-MSCs donated from mother 
      giving birth. The ulcer healing was measured by imaging the healing rate and the 
      H&E staining. CD31 and VEGF expression was measured with immunohistochemistry 
      assay. iTRAQ proteomics analysis was used to analyze the signaling pathway. The 
      results showed that hUC-MSCs improved healing of irradiation-induced skin ulcers 
      in vivo using a rat model of skin ulcer. Transplantation of hUC-MSCs promoted 
      keratin generation and keratinocytes proliferation of ulcer areas. Furthermore, 
      the results demonstrated that hUC-MSCs increased expression of CD31 and VEGF in 
      ulcers and promoted neovascularization. iTRAQ proteomics analysis results 
      indicated that PI3K/Akt signaling pathway involved in hUC-MSCs-mediated repairing 
      of irradiation-induced skin ulcer. In conclusion, human umbilical cord 
      mesenchymal stem cells promoted neovascularization and re-epithelization, and 
      improved healing of irradiation-induced skin ulcers. This healing improvement may 
      be conducted through activating the PI3K/Akt signaling pathway, however, which 
      needs to be proven by the further investigations.
CI  - Copyright (c) 2018 Elsevier Masson SAS. All rights reserved.
FAU - Liu, Zhongshan
AU  - Liu Z
AD  - Department of Plastic, The Second Affiliated Hospital of Soochow University, 
      Suzhou, China; Department of the Burns and Plastic, The Affiliated Hospital of 
      Guizhou Medical University, Guiyang, China.
FAU - Yu, Daojiang
AU  - Yu D
AD  - Department of Plastic, The Second Affiliated Hospital of Soochow University, 
      Suzhou, China.
FAU - Xu, Jianwei
AU  - Xu J
AD  - The Stem Cell and Tissue Engineering Research Center, Guizhou Medical University, 
      China.
FAU - Li, Xiujie
AU  - Li X
AD  - Department of Plastic, The Second Affiliated Hospital of Soochow University, 
      Suzhou, China.
FAU - Wang, Xianyao
AU  - Wang X
AD  - Department of Cell Biology, Jiangsu Key Laboratory of Stem Cell Research, Suzhou, 
      China.
FAU - He, Zhixu
AU  - He Z
AD  - The Stem Cell and Tissue Engineering Research Center, Guizhou Medical University, 
      China. Electronic address: hzx@gmc.edu.cn.
FAU - Zhao, Tianlan
AU  - Zhao T
AD  - Department of Plastic, The Second Affiliated Hospital of Soochow University, 
      Suzhou, China. Electronic address: tianlanzhao1965@yeah.net.
LA  - eng
PT  - Journal Article
DEP - 20180322
PL  - France
TA  - Biomed Pharmacother
JT  - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
JID - 8213295
SB  - IM
MH  - Animals
MH  - Cells, Cultured
MH  - Female
MH  - Humans
MH  - Male
MH  - Mesenchymal Stem Cell Transplantation/*methods
MH  - Mesenchymal Stem Cells/physiology
MH  - Pregnancy
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Skin Ulcer/pathology/*therapy
MH  - Ultraviolet Rays/*adverse effects
MH  - Umbilical Cord/cytology/*physiology/*transplantation
MH  - Wound Healing/*physiology
OTO - NOTNLM
OT  - Neovascularization
OT  - Radioactive skin ulcer
OT  - Re-epithelization
OT  - hUC-MSCs
EDAT- 2018/03/11 06:00
MHDA- 2018/09/25 06:00
CRDT- 2018/03/11 06:00
PHST- 2017/11/18 00:00 [received]
PHST- 2018/01/19 00:00 [revised]
PHST- 2018/02/20 00:00 [accepted]
PHST- 2018/03/11 06:00 [pubmed]
PHST- 2018/09/25 06:00 [medline]
PHST- 2018/03/11 06:00 [entrez]
AID - S0753-3322(17)36200-5 [pii]
AID - 10.1016/j.biopha.2018.02.093 [doi]
PST - ppublish
SO  - Biomed Pharmacother. 2018 May;101:729-736. doi: 10.1016/j.biopha.2018.02.093. 
      Epub 2018 Mar 22.