PMID- 29525096
OWN - NLM
STAT- MEDLINE
DCOM- 20180827
LR  - 20181202
IS  - 1873-0191 (Electronic)
IS  - 0928-4931 (Linking)
VI  - 86
DP  - 2018 May 1
TI  - Preparation and characterization of a novel host-guest complex based on 
      folate-modified beta-cyclodextrin and artesunate.
PG  - 48-55
LID - S0928-4931(17)32442-6 [pii]
LID - 10.1016/j.msec.2017.12.009 [doi]
AB  - The purpose of this study was to develop a novel folate-modified host-guest 
      complex to enhance antitumor activity of the artesunate and improve the 
      solubility and stability by encapsulated in beta-cyclodextrin and linked with 
      folate. In this work, we designed and prepared the inclusion complex of 
      adamantanamine conjugated artesunate (AD-ATS) with folic 
      acid-ethylenediamine-beta-cyclodextrin (FA-EN-beta-CD). This material was characterized 
      by 1D and 2D NMR, XRD, TG and SEM. The results suggested that AD-ATS was 
      encapsulated within the FA-EN-beta-CD cavity to form host-guest inclusion complex, 
      and the water solubility of AD-ATS was improved in the form of inclusion complex 
      with FA-EN-beta-CD. The assessment of antitumor activity showed that cytotoxicity of 
      AD-ATS/FA-EN-beta-CD complex was significantly enhanced in comparison to free 
      AD-ATS, ATS/beta-CD inclusion complex and ATS/FA-EN-beta-CD inclusion complex.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Zhang, Dongjing
AU  - Zhang D
AD  - Faculty of Life Science and Technology, Kunming University of Science and 
      Technology, Kunming 650500, PR China.
FAU - Zhou, Cheng
AU  - Zhou C
AD  - Faculty of Life Science and Technology, Kunming University of Science and 
      Technology, Kunming 650500, PR China.
FAU - Lv, Pin
AU  - Lv P
AD  - Faculty of Life Science and Technology, Kunming University of Science and 
      Technology, Kunming 650500, PR China.
FAU - Zhao, Yulin
AU  - Zhao Y
AD  - Faculty of Chemical Engineering, Kunming University of Science and Technology, 
      Kunming 650500, China.
FAU - Liang, Jing
AU  - Liang J
AD  - Faculty of Life Science and Technology, Kunming University of Science and 
      Technology, Kunming 650500, PR China.
FAU - Liao, Xiali
AU  - Liao X
AD  - Faculty of Life Science and Technology, Kunming University of Science and 
      Technology, Kunming 650500, PR China.
FAU - Yang, Bo
AU  - Yang B
AD  - Faculty of Life Science and Technology, Kunming University of Science and 
      Technology, Kunming 650500, PR China. Electronic address: yangbo6910@sina.com.
LA  - eng
PT  - Journal Article
DEP - 20180117
PL  - Netherlands
TA  - Mater Sci Eng C Mater Biol Appl
JT  - Materials science & engineering. C, Materials for biological applications
JID - 101484109
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Artemisinins)
RN  - 0 (Ethylenediamines)
RN  - 0 (beta-Cyclodextrins)
RN  - 0 (ethylene-diamine-beta-cyclodextrin)
RN  - 42381-05-5 (adamantanine)
RN  - 60W3249T9M (Artesunate)
RN  - 935E97BOY8 (Folic Acid)
RN  - BF4C9Z1J53 (Amantadine)
SB  - IM
MH  - Amantadine/analogs & derivatives/chemistry
MH  - Antineoplastic Agents/chemical synthesis/*chemistry/pharmacology
MH  - Artemisinins/*chemistry
MH  - Artesunate
MH  - Cell Line, Tumor
MH  - Cell Survival/drug effects
MH  - Ethylenediamines/*chemistry
MH  - Folic Acid/*chemistry
MH  - Humans
MH  - Magnetic Resonance Spectroscopy
MH  - Microscopy, Electron, Scanning
MH  - Solubility
MH  - Thermogravimetry
MH  - X-Ray Diffraction
MH  - beta-Cyclodextrins/*chemistry
OTO - NOTNLM
OT  - Antitumor activity
OT  - Artesunate
OT  - Folic acid-ethylenediamine-beta-cyclodextrin
OT  - Inclusion complex
OT  - Solubilization
EDAT- 2018/03/12 06:00
MHDA- 2018/08/28 06:00
CRDT- 2018/03/12 06:00
PHST- 2017/06/27 00:00 [received]
PHST- 2017/08/26 00:00 [revised]
PHST- 2017/12/07 00:00 [accepted]
PHST- 2018/03/12 06:00 [entrez]
PHST- 2018/03/12 06:00 [pubmed]
PHST- 2018/08/28 06:00 [medline]
AID - S0928-4931(17)32442-6 [pii]
AID - 10.1016/j.msec.2017.12.009 [doi]
PST - ppublish
SO  - Mater Sci Eng C Mater Biol Appl. 2018 May 1;86:48-55. doi: 
      10.1016/j.msec.2017.12.009. Epub 2018 Jan 17.