PMID- 29525545
OWN - NLM
STAT- MEDLINE
DCOM- 20180816
LR  - 20190307
IS  - 1873-5800 (Electronic)
IS  - 0968-0160 (Print)
IS  - 0968-0160 (Linking)
VI  - 25
IP  - 2
DP  - 2018 Mar
TI  - Time between anterior cruciate ligament injury and reconstruction and cartilage 
      metabolism six-months following reconstruction.
PG  - 296-305
LID - S0968-0160(18)30030-9 [pii]
LID - 10.1016/j.knee.2018.01.009 [doi]
AB  - BACKGROUND: To determine the association between time from injury to ACL 
      reconstruction (Time(Injury-ACLR)) and biochemical markers of cartilage 
      metabolism and inflammation six months following ACL reconstruction (ACLR). 
      METHODS: Individuals with a unilateral ACL injury were enrolled at initial 
      presentation in the orthopedic clinic; blood was collected six months following 
      ACLR. Enzyme-linked immunosorbent assays were used to analyze the ratio of serum 
      concentrations of type-II collagen breakdown (C2C) to synthesis (CPII), plasma 
      matrix metalloproteinase-3 (MMP-3), interleukin-6 (IL-6), and serum aggrecan 
      neoepitope (ARGS). We used separate linear regressions to assess associations 
      between biochemical markers and Time(Injury-ACLR). RESULTS: Twenty-two 
      participants (50% females, mean [SD], age 21.9 [4.5] years old; BMI 23.8 [2.6] 
      kg/m(2)) completed the study. Time(Injury-ACLR) ranged from nine to 67days (31.0 
      [14.4days]). Greater Time(Injury-ACLR) predicted greater serum C2C:CPII ratios 
      six months following ACLR (C2C:CPII=0.15 [0.02], R(2)=0.213, P=0.030). Males 
      (R(2)=0.733, P=0.001) but not females (R(2)=0.030, P=0.609) demonstrated a 
      significant association between greater C2C:CPII and Time(Injury-ACLR) at the 
      six-month follow-up exam. Time(Injury-ACLR) did not associate with IL-6, MMP-3, 
      or ARGS at six months. CONCLUSIONS: Greater time between injury and ACL 
      reconstruction was associated with greater serum C2C:CPII six months following 
      ACLR in males but not females, and IL-6, MMP-3, and ARGS levels were not 
      associated with Time(Injury-ACLR) in males or females. The time between ACL 
      injury and ACLR may affect collagen metabolism in males and should be further 
      investigated in a larger study along with other patient-relevant outcomes.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Davis, Hope C
AU  - Davis HC
AD  - Human Movement Science Curriculum, University of North Carolina at Chapel Hill, 
      Chapel Hill, NC, United States. Electronic address: davishc@live.unc.edu.
FAU - Spang, Jeffery T
AU  - Spang JT
AD  - Department of Orthopaedics, School of Medicine, University of North Carolina at 
      Chapel Hill, NC, United States.
FAU - Loeser, Richard F
AU  - Loeser RF
AD  - Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, 
      NC, United States.
FAU - Larsson, Staffan
AU  - Larsson S
AD  - Lund University, Department of Clinical Sciences, Orthopaedics, Lund, Sweden.
FAU - Ulici, Veronica
AU  - Ulici V
AD  - Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, 
      NC, United States.
FAU - Troy Blackburn, J
AU  - Troy Blackburn J
AD  - Human Movement Science Curriculum, University of North Carolina at Chapel Hill, 
      Chapel Hill, NC, United States; Department of Exercise and Sport Science, 
      University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
FAU - Creighton, R Alexander
AU  - Creighton RA
AD  - Department of Orthopaedics, School of Medicine, University of North Carolina at 
      Chapel Hill, NC, United States.
FAU - Kamath, Ganesh M
AU  - Kamath GM
AD  - Department of Orthopaedics, School of Medicine, University of North Carolina at 
      Chapel Hill, NC, United States.
FAU - Jordan, Joanne M
AU  - Jordan JM
AD  - Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, 
      NC, United States.
FAU - Marshall, Stephen W
AU  - Marshall SW
AD  - Injury Prevention Research Center, University of North Carolina at Chapel Hill, 
      NC, United States.
FAU - Pietrosimone, Brian
AU  - Pietrosimone B
AD  - Human Movement Science Curriculum, University of North Carolina at Chapel Hill, 
      Chapel Hill, NC, United States; Department of Exercise and Sport Science, 
      University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
LA  - eng
GR  - R03 AR066840/AR/NIAMS NIH HHS/United States
PT  - Journal Article
DEP - 20180307
PL  - Netherlands
TA  - Knee
JT  - The Knee
JID - 9430798
RN  - 0 (Aggrecans)
RN  - 0 (Collagen Type II)
RN  - 0 (Interleukin-6)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Aggrecans/blood
MH  - Anterior Cruciate Ligament Injuries/*surgery
MH  - Cartilage, Articular/*metabolism
MH  - Chondrogenesis
MH  - Cohort Studies
MH  - Collagen Type II/blood
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Interleukin-6/blood
MH  - Linear Models
MH  - Male
MH  - Matrix Metalloproteinase 3/blood
MH  - Time-to-Treatment
MH  - Young Adult
PMC - PMC5886724
MID - NIHMS949251
OTO - NOTNLM
OT  - ACLR
OT  - Biomarkers
OT  - C-propeptide of type II procollagen
OT  - C2C
OT  - CPII
OT  - Type-II collagen cleavage product
COIS- Conflicts of Interest We wish to confirm that there are no known conflicts of 
      interest associated with this publication and there has been no significant 
      financial support for this work that could have influenced its outcome.
EDAT- 2018/03/12 06:00
MHDA- 2018/08/17 06:00
PMCR- 2019/03/07
CRDT- 2018/03/12 06:00
PHST- 2017/10/25 00:00 [received]
PHST- 2018/01/02 00:00 [revised]
PHST- 2018/01/28 00:00 [accepted]
PHST- 2018/03/12 06:00 [pubmed]
PHST- 2018/08/17 06:00 [medline]
PHST- 2018/03/12 06:00 [entrez]
PHST- 2019/03/07 00:00 [pmc-release]
AID - S0968-0160(18)30030-9 [pii]
AID - 10.1016/j.knee.2018.01.009 [doi]
PST - ppublish
SO  - Knee. 2018 Mar;25(2):296-305. doi: 10.1016/j.knee.2018.01.009. Epub 2018 Mar 7.