PMID- 29525572
OWN - NLM
STAT- MEDLINE
DCOM- 20180921
LR  - 20210109
IS  - 2352-3964 (Electronic)
IS  - 2352-3964 (Linking)
VI  - 30
DP  - 2018 Apr
TI  - Endogenous Mobilization of Bone-Marrow Cells Into the Murine Retina Induces 
      Fusion-Mediated Reprogramming of Muller Glia Cells.
PG  - 38-51
LID - S2352-3964(18)30077-X [pii]
LID - 10.1016/j.ebiom.2018.02.023 [doi]
AB  - Muller glial cells (MGCs) represent the most plastic cell type found in the 
      retina. Following injury, zebrafish and avian MGCs can efficiently re-enter the 
      cell cycle, proliferate and generate new functional neurons. The regenerative 
      potential of mammalian MGCs, however, is very limited. Here, we showed that 
      N-methyl-d-aspartate (NMDA) damage stimulates murine MGCs to re-enter the cell 
      cycle and de-differentiate back to a progenitor-like stage. These events are 
      dependent on the recruitment of endogenous bone marrow cells (BMCs), which, in 
      turn, is regulated by the stromal cell-derived factor 1 (SDF1)-C-X-C motif 
      chemokine receptor type 4 (CXCR4) pathway. BMCs mobilized into the damaged retina 
      can fuse with resident MGCs, and the resulting hybrids undergo reprogramming 
      followed by re-differentiation into cells expressing markers of ganglion and 
      amacrine neurons. Our findings constitute an important proof-of-principle that 
      mammalian MGCs retain their regenerative potential, and that such potential can 
      be activated via cell fusion with recruited BMCs. In this perspective, our study 
      could contribute to the development of therapeutic strategies based on the 
      enhancement of mammalian endogenous repair capabilities.
CI  - Copyright (c) 2018 German Center for Neurodegenerative Diseases (DZNE). Published 
      by Elsevier B.V. All rights reserved.
FAU - Pesaresi, Martina
AU  - Pesaresi M
AD  - Center for Genomic Regulation (CRG), The Barcelona Institute of Science and 
      Technology, Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain.
FAU - Bonilla-Pons, Sergi A
AU  - Bonilla-Pons SA
AD  - Center for Genomic Regulation (CRG), The Barcelona Institute of Science and 
      Technology, Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain.; 
      Universitat de Barcelona (UB), Barcelona, Spain.
FAU - Simonte, Giacoma
AU  - Simonte G
AD  - Center for Genomic Regulation (CRG), The Barcelona Institute of Science and 
      Technology, Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain.
FAU - Sanges, Daniela
AU  - Sanges D
AD  - Center for Genomic Regulation (CRG), The Barcelona Institute of Science and 
      Technology, Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain.
FAU - Di Vicino, Umberto
AU  - Di Vicino U
AD  - Center for Genomic Regulation (CRG), The Barcelona Institute of Science and 
      Technology, Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain.
FAU - Cosma, Maria Pia
AU  - Cosma MP
AD  - Center for Genomic Regulation (CRG), The Barcelona Institute of Science and 
      Technology, Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain.; 
      ICREA, Barcelona, Spain.. Electronic address: pia.cosma@crg.es.
LA  - eng
PT  - Journal Article
DEP - 20180228
PL  - Netherlands
TA  - EBioMedicine
JT  - EBioMedicine
JID - 101647039
RN  - 0 (Chemokine CXCL12)
RN  - 0 (Cxcl12 protein, mouse)
RN  - 0 (Receptors, CXCR4)
RN  - 6384-92-5 (N-Methylaspartate)
SB  - IM
MH  - Amacrine Cells/cytology/drug effects
MH  - Animals
MH  - Bone Marrow Cells/*cytology/drug effects/metabolism
MH  - Cell Dedifferentiation/drug effects
MH  - Cell Fusion
MH  - Cell Proliferation/drug effects
MH  - *Cellular Reprogramming/drug effects
MH  - Chemokine CXCL12/metabolism
MH  - Mice, Transgenic
MH  - N-Methylaspartate/toxicity
MH  - Neuroglia/*cytology/drug effects
MH  - Receptors, CXCR4/metabolism
MH  - Retina/*cytology
MH  - Retinal Ganglion Cells/cytology/drug effects
MH  - Signal Transduction
PMC - PMC5952225
OTO - NOTNLM
OT  - Bone-marrow cells
OT  - Cell fusion-mediated reprogramming
OT  - Endogenous migration
OT  - Muller glial cells
OT  - NMDA-damage
OT  - Retinal damage
OT  - SDF1/CXCR4 pathway
EDAT- 2018/03/12 06:00
MHDA- 2018/09/22 06:00
PMCR- 2018/02/28
CRDT- 2018/03/12 06:00
PHST- 2017/06/06 00:00 [received]
PHST- 2018/02/02 00:00 [revised]
PHST- 2018/02/26 00:00 [accepted]
PHST- 2018/03/12 06:00 [pubmed]
PHST- 2018/09/22 06:00 [medline]
PHST- 2018/03/12 06:00 [entrez]
PHST- 2018/02/28 00:00 [pmc-release]
AID - S2352-3964(18)30077-X [pii]
AID - 10.1016/j.ebiom.2018.02.023 [doi]
PST - ppublish
SO  - EBioMedicine. 2018 Apr;30:38-51. doi: 10.1016/j.ebiom.2018.02.023. Epub 2018 Feb 
      28.