PMID- 29525890
OWN - NLM
STAT- MEDLINE
DCOM- 20190903
LR  - 20210109
IS  - 1436-6215 (Electronic)
IS  - 1436-6207 (Print)
IS  - 1436-6207 (Linking)
VI  - 58
IP  - 2
DP  - 2019 Mar
TI  - Prospective associations of dietary carbohydrate, fat, and protein intake with 
      beta-cell function in the CODAM study.
PG  - 597-608
LID - 10.1007/s00394-018-1644-y [doi]
AB  - PURPOSE: Type 2 diabetes mellitus (T2DM) is characterized by both impaired 
      pancreatic beta-cell function (BCF) and insulin resistance. In the etiology of T2DM, 
      BCF basically determines whether a person with a certain degree of insulin 
      resistance develops T2DM, as beta-cells are able to compensatorily increase insulin 
      secretion. The effects of dietary intake on BCF are largely unknown. Our study 
      aim was to investigate whether dietary macronutrient intake predicts BCF. 
      METHODS: Prospective data (median follow-up 7 years) of 303 individuals recruited 
      from the CODAM study population (aged 40-70 years, 39% women) were analyzed. BCF 
      was measured by C-peptide deconvolution and physiological modeling of data from a 
      5-point, 75-g, 2-h oral glucose tolerance test. Macronutrient intake was 
      estimated by a 178-item Food Frequency Questionnaire. RESULTS: Associations 
      adjusted for relevant covariates of baseline macronutrient intake with 
      model-derived parameters describing BCF (glucose sensitivity, rate sensitivity or 
      potentiation) or C-peptidogenic index were detected for trans fat [standardized 
      regression coefficient (95%-CI) glucose sensitivity - 0.14 (- 0.26, - 0.01)] per 
      g, cholesterol [potentiation 0.20 (0.02, 0.37)] per 100 mg, dietary fiber 
      [glucose sensitivity 0.21 (0.08, 0.33)] per 10 g, MUFA glucose sensitivity 0.16 
      (0.02, 0.31) per 10 g, and polysaccharide [potentiation - 0.24 (- 0.43, - 0.05), 
      C-peptidogenic index - 0.16 (- 0.29 - 0.03); odds ratio lowest versus highest 
      tertile (95%-CI) rate sensitivity 1.51 (1.06, 2.15)) per 50 g. CONCLUSIONS: In 
      this population at high risk for developing T2DM, polysaccharide and trans fat 
      intake were associated with worse BCF, whereas increased intake of MUFA, dietary 
      cholesterol, and fiber were associated with better BCF.
FAU - den Biggelaar, Louise J C J
AU  - den Biggelaar LJCJ
AD  - Department of Epidemiology, Maastricht University, P.O. Box 616, 6200 MD, 
      Maastricht, The Netherlands.
AD  - School for Cardiovascular Diseases (CARIM), Maastricht University, Maastricht, 
      The Netherlands.
AD  - Department of Internal Medicine, Maastricht University Medical Centre, 
      Maastricht, The Netherlands.
FAU - Eussen, Simone J P M
AU  - Eussen SJPM
AUID- ORCID: 0000-0003-0559-6838
AD  - Department of Epidemiology, Maastricht University, P.O. Box 616, 6200 MD, 
      Maastricht, The Netherlands. simone.eussen@maastrichtuniversity.nl.
AD  - School for Cardiovascular Diseases (CARIM), Maastricht University, Maastricht, 
      The Netherlands. simone.eussen@maastrichtuniversity.nl.
AD  - Care and Public Health Research Institute (CAPHRI), Maastricht University, 
      Maastricht, The Netherlands. simone.eussen@maastrichtuniversity.nl.
AD  - Department of Internal Medicine, Maastricht University Medical Centre, 
      Maastricht, The Netherlands. simone.eussen@maastrichtuniversity.nl.
FAU - Sep, Simone J S
AU  - Sep SJS
AD  - Care and Public Health Research Institute (CAPHRI), Maastricht University, 
      Maastricht, The Netherlands.
AD  - Centre of Expertise in Rehabilitation and Audiology, Adelante, Hoensbroek, The 
      Netherlands.
AD  - Department of Internal Medicine, Maastricht University Medical Centre, 
      Maastricht, The Netherlands.
FAU - Mari, Andrea
AU  - Mari A
AD  - CNR Institute of Clinical Physiology, Pisa, Italy.
AD  - Department of Internal Medicine, Maastricht University Medical Centre, 
      Maastricht, The Netherlands.
FAU - Ferrannini, Ele
AU  - Ferrannini E
AD  - CNR Institute of Neuroscience, Padova, Italy.
AD  - Department of Internal Medicine, Maastricht University Medical Centre, 
      Maastricht, The Netherlands.
FAU - van Greevenbroek, Marleen M
AU  - van Greevenbroek MM
AD  - School for Cardiovascular Diseases (CARIM), Maastricht University, Maastricht, 
      The Netherlands.
AD  - Department of Internal Medicine, Maastricht University Medical Centre, 
      Maastricht, The Netherlands.
FAU - van der Kallen, Carla J
AU  - van der Kallen CJ
AD  - School for Cardiovascular Diseases (CARIM), Maastricht University, Maastricht, 
      The Netherlands.
AD  - Department of Internal Medicine, Maastricht University Medical Centre, 
      Maastricht, The Netherlands.
FAU - Schalkwijk, Casper G
AU  - Schalkwijk CG
AD  - School for Cardiovascular Diseases (CARIM), Maastricht University, Maastricht, 
      The Netherlands.
AD  - Department of Internal Medicine, Maastricht University Medical Centre, 
      Maastricht, The Netherlands.
FAU - Arts, Ilja C W
AU  - Arts ICW
AD  - School for Cardiovascular Diseases (CARIM), Maastricht University, Maastricht, 
      The Netherlands.
AD  - Maastricht Centre for Systems Biology (MaCSBio), Maastricht University, 
      Maastricht, The Netherlands.
FAU - Stehouwer, Coen D A
AU  - Stehouwer CDA
AD  - School for Cardiovascular Diseases (CARIM), Maastricht University, Maastricht, 
      The Netherlands.
AD  - Department of Internal Medicine, Maastricht University Medical Centre, 
      Maastricht, The Netherlands.
FAU - Dagnelie, Pieter C
AU  - Dagnelie PC
AD  - Department of Epidemiology, Maastricht University, P.O. Box 616, 6200 MD, 
      Maastricht, The Netherlands.
AD  - School for Cardiovascular Diseases (CARIM), Maastricht University, Maastricht, 
      The Netherlands.
AD  - Care and Public Health Research Institute (CAPHRI), Maastricht University, 
      Maastricht, The Netherlands.
AD  - Department of Internal Medicine, Maastricht University Medical Centre, 
      Maastricht, The Netherlands.
LA  - eng
PT  - Journal Article
DEP - 20180310
PL  - Germany
TA  - Eur J Nutr
JT  - European journal of nutrition
JID - 100888704
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Dietary Fats)
RN  - 0 (Dietary Proteins)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cohort Studies
MH  - Diabetes Mellitus, Type 2/*metabolism
MH  - Dietary Carbohydrates/metabolism/*pharmacology
MH  - Dietary Fats/metabolism/*pharmacology
MH  - Dietary Proteins/metabolism/*pharmacology
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Insulin-Secreting Cells/*metabolism
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
PMC - PMC6437317
OTO - NOTNLM
OT  - Carbohydrate
OT  - Fat
OT  - Protein
OT  - Type 2 diabetes mellitus
OT  - beta-Cell function
COIS- The authors declare that they have no conflict of interest.
EDAT- 2018/03/12 06:00
MHDA- 2019/09/04 06:00
PMCR- 2018/03/10
CRDT- 2018/03/12 06:00
PHST- 2017/07/20 00:00 [received]
PHST- 2018/02/19 00:00 [accepted]
PHST- 2018/03/12 06:00 [pubmed]
PHST- 2019/09/04 06:00 [medline]
PHST- 2018/03/12 06:00 [entrez]
PHST- 2018/03/10 00:00 [pmc-release]
AID - 10.1007/s00394-018-1644-y [pii]
AID - 1644 [pii]
AID - 10.1007/s00394-018-1644-y [doi]
PST - ppublish
SO  - Eur J Nutr. 2019 Mar;58(2):597-608. doi: 10.1007/s00394-018-1644-y. Epub 2018 Mar 
      10.