PMID- 2952590
OWN - NLM
STAT- MEDLINE
DCOM- 19870605
LR  - 20190722
IS  - 0194-911X (Print)
IS  - 0194-911X (Linking)
VI  - 9
IP  - 5
DP  - 1987 May
TI  - Atrial natriuretic factor inhibits central angiotensin II pressor responses.
PG  - 473-7
AB  - Intracerebroventricular (i.c.v.) administration of human atrial natriuretic 
      factor (ANF), fragment 1-25, in the dose range 3 to 20 micrograms/kg did not 
      alter resting arterial pressure or heart rate in rats anesthetized with 
      chloralose/urethan (60:600 mg/kg i.p.), while angiotensin II (ANG II), 1 
      microgram/kg, produced a significant increase in arterial pressure after i.c.v. 
      application. This pressor effect induced by ANG II was abolished by simultaneous 
      administration of ANF (3 micrograms/kg i.c.v.). In isolated strips of rabbit 
      aorta preconstricted with ANG II (10 nM), ANF caused a dose-dependent relaxation. 
      In intact rats, the increase in blood pressure following intravenously 
      administered ANG II (0.1 and 1 microgram/kg) was not altered by the highest dose 
      of ANF (20 micrograms/kg) given intracerebroventricularly. These results suggest 
      that atrial peptides may play an important role in the regulation of blood 
      pressure by interacting with both the central and peripheral actions of ANG II. 
      Inhibition of the central pressor action of angiotensin by ANF appears to be 
      independent of any direct peripheral effect of the atrial peptides.
FAU - Casto, R
AU  - Casto R
FAU - Hilbig, J
AU  - Hilbig J
FAU - Schroeder, G
AU  - Schroeder G
FAU - Stock, G
AU  - Stock G
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Hypertension
JT  - Hypertension (Dallas, Tex. : 1979)
JID - 7906255
RN  - 11128-99-7 (Angiotensin II)
RN  - 85637-73-6 (Atrial Natriuretic Factor)
SB  - IM
MH  - Angiotensin II/*antagonists & inhibitors/pharmacology
MH  - Animals
MH  - Atrial Natriuretic Factor/*pharmacology
MH  - Blood Pressure/*drug effects
MH  - Heart Rate/drug effects
MH  - In Vitro Techniques
MH  - Injections, Intraventricular
MH  - Male
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Vasoconstriction/drug effects
EDAT- 1987/05/01 00:00
MHDA- 1987/05/01 00:01
CRDT- 1987/05/01 00:00
PHST- 1987/05/01 00:00 [pubmed]
PHST- 1987/05/01 00:01 [medline]
PHST- 1987/05/01 00:00 [entrez]
AID - 10.1161/01.hyp.9.5.473 [doi]
PST - ppublish
SO  - Hypertension. 1987 May;9(5):473-7. doi: 10.1161/01.hyp.9.5.473.