PMID- 29526693
OWN - NLM
STAT- MEDLINE
DCOM- 20190619
LR  - 20190619
IS  - 1095-8304 (Electronic)
IS  - 0195-6663 (Linking)
VI  - 125
DP  - 2018 Jun 1
TI  - Beverages containing low energy sweeteners do not differ from water in their 
      effects on appetite, energy intake and food choices in healthy, non-obese French 
      adults.
PG  - 557-565
LID - S0195-6663(18)30066-7 [pii]
LID - 10.1016/j.appet.2018.03.007 [doi]
AB  - The usefulness of replacement of caloric sugars by low-calorie sweeteners (LCS) 
      for weight management has been questioned on the grounds that the uncoupling of 
      LCS sweet taste and dietary energy may confuse physiological mechanisms, leading 
      potentially to higher energy and sugar intake. The aim of the present study was 
      to determine whether LCS beverages compared to water, when consumed with meals, 
      differ in their effects on energy and food intake in acute trials and after 
      long-term habituation. Ad libitum food intake of 166 (80 women; 86 men) healthy 
      non-obese adults (BMI between 19 and 28 kg/m2), infrequent consumers of LCS was 
      measured in four 2-consecutive-day testing sessions (Day 1 in the laboratory, Day 
      2 free-living). During the first 3 sessions, held one-week apart, participants 
      were required to drink either water or commercial non-carbonated LCS lemonade 
      (330 ml) with their main meals (randomised cross-over design). On Day 1, 
      motivational ratings were obtained using visual analogue scales and ad libitum 
      food intakes (amounts and types of foods selected) were measured using the plate 
      waste method. On Day 2, participants reported their ad libitum intakes using a 
      food diary. After Session 3, participants were randomly assigned to the LCS 
      habituation group or to the water control group. The habituation (660 ml LCS 
      lemonade daily vs 660 ml water) lasted 5 weeks. The fourth and final test session 
      measured food intakes and motivational ratings after habituation. Water and LCS 
      beverage did not differ in their effects on total energy intake, macronutrient 
      intakes or the selection of sweet foods and on motivational ratings. Similar 
      results were obtained in both LCS-naive and LCS-habituated individuals.
FAU - Fantino, Marc
AU  - Fantino M
AD  - CreaBio-Rhone-Alpes Research Centre, Centre Hospitalier Regional de Montgelas, 9 
      Avenue Professeur Fleming, F-69700 Givors, France. Electronic address: 
      marc.fantino@creabio-ra.com.
FAU - Fantino, Agnes
AU  - Fantino A
AD  - CreaBio-Rhone-Alpes Research Centre, Centre Hospitalier Regional de Montgelas, 9 
      Avenue Professeur Fleming, F-69700 Givors, France.
FAU - Matray, Marie
AU  - Matray M
AD  - CreaBio-Rhone-Alpes Research Centre, Centre Hospitalier Regional de Montgelas, 9 
      Avenue Professeur Fleming, F-69700 Givors, France.
FAU - Mistretta, Frederic
AU  - Mistretta F
AD  - RCTS Ltd, 38 rue du Plat, F-69002 Lyon, France.
LA  - eng
SI  - ClinicalTrials.gov/NCT02297880
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20180309
PL  - England
TA  - Appetite
JT  - Appetite
JID - 8006808
RN  - 0 (Non-Nutritive Sweeteners)
RN  - 0 (Thiazines)
RN  - 059QF0KO0R (Water)
RN  - 57-50-1 (Sucrose)
RN  - 96K6UQ3ZD4 (trichlorosucrose)
RN  - MA3UYZ6K1H (acetosulfame)
RN  - Z0H242BBR1 (Aspartame)
SB  - IM
RPI - Appetite. 2018 Oct 1;129:103-112. doi: 10.1016/j.appet.2018.06.036. PMID: 
      30005211
MH  - Adult
MH  - Appetite/*drug effects
MH  - Aspartame/pharmacology
MH  - *Beverages
MH  - *Choice Behavior
MH  - Citrus
MH  - Diet
MH  - Drinking
MH  - Energy Intake/*drug effects
MH  - Female
MH  - Food Preferences/*drug effects
MH  - France
MH  - Humans
MH  - Male
MH  - Meals
MH  - Non-Nutritive Sweeteners/*pharmacology
MH  - Nutrition Surveys
MH  - Reference Values
MH  - Sucrose/analogs & derivatives/pharmacology
MH  - Thiazines/pharmacology
MH  - Water/*pharmacology
OTO - NOTNLM
OT  - Energy intake
OT  - Human subjects
OT  - Low calories sweeteners (LCS)
OT  - Not habitual LCS users
OT  - Sugar intake
OT  - Sweet/savory food choices
EDAT- 2018/03/13 06:00
MHDA- 2019/06/20 06:00
CRDT- 2018/03/13 06:00
PHST- 2018/01/16 00:00 [received]
PHST- 2018/03/07 00:00 [revised]
PHST- 2018/03/07 00:00 [accepted]
PHST- 2018/03/13 06:00 [pubmed]
PHST- 2019/06/20 06:00 [medline]
PHST- 2018/03/13 06:00 [entrez]
AID - S0195-6663(18)30066-7 [pii]
AID - 10.1016/j.appet.2018.03.007 [doi]
PST - ppublish
SO  - Appetite. 2018 Jun 1;125:557-565. doi: 10.1016/j.appet.2018.03.007. Epub 2018 Mar 
      9.