PMID- 29526844
OWN - NLM
STAT- MEDLINE
DCOM- 20180601
LR  - 20181202
IS  - 1875-8622 (Electronic)
IS  - 1386-0291 (Linking)
VI  - 68
IP  - 4
DP  - 2018
TI  - Effects of endurance training on hsa-miR-223, P2RY12 receptor expression and 
      platelet function in type 2 diabetic patients.
PG  - 391-399
LID - 10.3233/CH-170300 [doi]
AB  - BACKGROUND: Type 2 diabetes mellitus (T2DM) is associated with thrombotic events 
      due to platelets' defects. OBJECTIVE: The aim of this study was to investigate 
      the effects of endurance training on expressions of platelet hsa-miR-223 and 
      P2RY12 receptor, as well as platelet function in T2DM patients. METHODS: Twenty 
      female T2DM patients (age, 62.25+/-3.81 yr; weight, 73.53+/-9.04 kg; height, 
      154.7+/-4.3 cm) were randomly divided into two groups (Control (CONT) and endurance 
      training (ET)). Subjects in ET group performed eight weeks of running on 
      treadmill at 60-75% of VO2peak (moderate intensity), 3 sessions per week, while, 
      the subjects in control group were not involved in any kind of exercise training. 
      Two blood samples were taken before and 48 h after the training and were analyzed 
      for platelet aggregation, and hsa-miR-223 and P2RY12 expressions. RESULTS: 
      Although platelet aggregation decreased significantly in ET group (P <  0.05), 
      these changes were not significantly different between two groups. Expression of 
      platelet hsa-miR-223 increased and P2RY12 mRNA reduced following ET 
      non-significantly. However, decreases in fasting blood glucose, glycated 
      hemoglobin and body weight, and increases in VO2peak following ET were 
      significantly different when compared to control group (P <  0.05). CONCLUSIONS: 
      Short-term endurance training dose not induce up-regulation of hsa-miR-223 and 
      down-regulation of P2RY12, while it has a positive impact on platelet function, 
      glycemic indices, physical fitness and body composition in female T2DM patients.
FAU - Taghizadeh, Mahmoudreza
AU  - Taghizadeh M
AD  - Department of Biological Sciences in Sport, Faculty of Sports Sciences and 
      Health, Shahid Beheshti University, Iran.
FAU - Ahmadizad, Sajad
AU  - Ahmadizad S
AD  - Department of Biological Sciences in Sport, Faculty of Sports Sciences and 
      Health, Shahid Beheshti University, Iran.
FAU - Naderi, Mahmood
AU  - Naderi M
AD  - Cell-Based Therapies Research Center, Digestive Disease Research Institute, 
      Tehran University of Medical Science, Tehran, Iran.
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Clin Hemorheol Microcirc
JT  - Clinical hemorheology and microcirculation
JID - 9709206
RN  - 0 (MIRN223 microRNA, human)
RN  - 0 (MicroRNAs)
RN  - 0 (P2RY12 protein, human)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Purinergic P2Y12)
SB  - IM
MH  - Blood Platelets/*metabolism
MH  - Diabetes Mellitus, Type 2/*blood/genetics
MH  - Female
MH  - Humans
MH  - MicroRNAs/*biosynthesis/blood
MH  - Middle Aged
MH  - Platelet Aggregation/*physiology
MH  - Platelet Function Tests
MH  - RNA, Messenger/blood/genetics
MH  - Receptors, Purinergic P2Y12/*biosynthesis/blood/genetics
OTO - NOTNLM
OT  - ADP receptor
OT  - Diabetes
OT  - aerobic training
OT  - microRNA
OT  - platelet aggregation
EDAT- 2018/03/13 06:00
MHDA- 2018/06/02 06:00
CRDT- 2018/03/13 06:00
PHST- 2018/03/13 06:00 [pubmed]
PHST- 2018/06/02 06:00 [medline]
PHST- 2018/03/13 06:00 [entrez]
AID - CH170300 [pii]
AID - 10.3233/CH-170300 [doi]
PST - ppublish
SO  - Clin Hemorheol Microcirc. 2018;68(4):391-399. doi: 10.3233/CH-170300.