PMID- 29526852
OWN - NLM
STAT- MEDLINE
DCOM- 20181009
LR  - 20181009
IS  - 1878-3627 (Electronic)
IS  - 0922-6028 (Linking)
VI  - 36
IP  - 2
DP  - 2018
TI  - Plantar stimulation in parkinsonians: From biomarkers to mobility - 
      randomized-controlled trial.
PG  - 195-205
LID - 10.3233/RNN-170744 [doi]
AB  - BACKGROUND: The decrease of Brain-Derived Neurotrophic Factor (BDNF) serum levels 
      has been related to the pathophysiology of several neurodegenerative diseases as 
      well as to neural plasticity and rehabilitation. Automated Mechanical Peripheral 
      Stimulation (AMPS) has been investigated as a complementary therapy for Parkinson 
      Disease (PD). OBJECTIVES: (1) to investigate the effects of AMPS on BDNF and 
      Cortisol serum levels of subjects with PD; (2) to evidence the interplay between 
      BDNF and Cortisol serum levels and the functional mobility improvement after AMPS 
      treatment. METHODS: Thirty-three subjects with PD were randomized into two 
      groups: effective stimulation (AMPS, n = 16) or placebo stimulation (AMPS SHAM, 
      n = 17). Fourteen healthy aged-matched subjects were included as a reference 
      group. Each AMPS group received eight sessions of treatment using a commercial 
      medical device (Gondola). BDNF and Cortisol serum levels, spatiotemporal gait 
      parameters and TUG test were assessed at baseline and after eight sessions of 
      treatment. RESULTS: After the treatment, AMPS group showed significantly higher 
      levels of BDNF and lower levels of Cortisol compared to AMPS SHAM. AMPS group 
      also showed a positive effect on gait pattern as a higher improvement on gait 
      velocity, stride length, and TUG performance was shown. CONCLUSION: Effective 
      AMPS treatment increased BDNF and decreased Cortisol serum levels and produced 
      improvements in functional mobility.
FAU - Pagnussat, Aline Souza
AU  - Pagnussat AS
AD  - Graduate Program in Rehabilitation Sciences, Universidade Federal de Ciencias da 
      Saude de Porto Alegre (UFCSPA), Porto Alegre, Brazil.
AD  - Movement Analysis and Neurological Rehabilitation Laboratory, Universidade 
      Federal de Ciencias da Saude de Porto Alegre (UFCSPA), Porto Alegre, Brazil.
FAU - Kleiner, Ana F R
AU  - Kleiner AFR
AD  - Politecnico di Milano, Dipartimento di Elettronica, Informazione e Bioingegneria, 
      Milan, Italy.
FAU - Rieder, Carlos R M
AU  - Rieder CRM
AD  - Graduate Program in Rehabilitation Sciences, Universidade Federal de Ciencias da 
      Saude de Porto Alegre (UFCSPA), Porto Alegre, Brazil.
FAU - Frantz, Anapaula
AU  - Frantz A
AD  - Movement Analysis and Neurological Rehabilitation Laboratory, Universidade 
      Federal de Ciencias da Saude de Porto Alegre (UFCSPA), Porto Alegre, Brazil.
FAU - Ehlers, Jaira
AU  - Ehlers J
AD  - Movement Analysis and Neurological Rehabilitation Laboratory, Universidade 
      Federal de Ciencias da Saude de Porto Alegre (UFCSPA), Porto Alegre, Brazil.
FAU - Pinto, Camila
AU  - Pinto C
AD  - Movement Analysis and Neurological Rehabilitation Laboratory, Universidade 
      Federal de Ciencias da Saude de Porto Alegre (UFCSPA), Porto Alegre, Brazil.
FAU - Dorneles, Gilson
AU  - Dorneles G
AD  - Cellular and Molecular Immunology Laboratory, Universidade Federal de Ciencias da 
      Saude de Porto Alegre (UFCSPA), Porto Alegre, Brazil.
FAU - Netto, Carlos Alexandre
AU  - Netto CA
AD  - Department of Biochemistry, Universidade Federal de Ciencias da Saude de Porto 
      Alegre (UFCSPA), Porto Alegre, Brazil.
FAU - Peres, Alessandra
AU  - Peres A
AD  - Cellular and Molecular Immunology Laboratory, Universidade Federal de Ciencias da 
      Saude de Porto Alegre (UFCSPA), Porto Alegre, Brazil.
AD  - Research Center, Methodist University Center IPA, Porto Alegre, Brazil.
FAU - Galli, Manuela
AU  - Galli M
AD  - Politecnico di Milano, Dipartimento di Elettronica, Informazione e Bioingegneria, 
      Milan, Italy.
AD  - "Gait Analysis Lab" IRCCS San Raffaele Pisana, Rome, Italy.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - Netherlands
TA  - Restor Neurol Neurosci
JT  - Restorative neurology and neuroscience
JID - 9005499
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - Aged
MH  - Brain-Derived Neurotrophic Factor/blood
MH  - Case-Control Studies
MH  - Double-Blind Method
MH  - Female
MH  - Foot/*innervation
MH  - Gait/physiology
MH  - Humans
MH  - Hydrocortisone/blood
MH  - Male
MH  - Middle Aged
MH  - Parkinson Disease/blood/*physiopathology/*rehabilitation
MH  - Physical Stimulation/*methods
MH  - Retrospective Studies
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Gondola
OT  - Parkinson Disease
OT  - automated mechanical peripheral stimulation
OT  - brain-derived neurotrophic factor
OT  - glucocorticoids
OT  - rehabilitation
EDAT- 2018/03/13 06:00
MHDA- 2018/10/10 06:00
CRDT- 2018/03/13 06:00
PHST- 2018/03/13 06:00 [entrez]
PHST- 2018/03/13 06:00 [pubmed]
PHST- 2018/10/10 06:00 [medline]
AID - RNN170744 [pii]
AID - 10.3233/RNN-170744 [doi]
PST - ppublish
SO  - Restor Neurol Neurosci. 2018;36(2):195-205. doi: 10.3233/RNN-170744.