PMID- 29527489 OWN - NLM STAT- MEDLINE DCOM- 20190130 LR - 20231112 IS - 2213-1582 (Electronic) IS - 2213-1582 (Linking) VI - 17 DP - 2018 TI - Dynamic functional connectivity in Parkinson's disease patients with mild cognitive impairment and normal cognition. PG - 847-855 LID - S2213-1582(17)30318-2 [pii] LID - 10.1016/j.nicl.2017.12.013 [doi] AB - The objective was to assess dynamic functional connectivity (FC) and local/global connectivity in Parkinson's disease (PD) patients with mild cognitive impairment (PD-MCI) and with normal cognition (PD-NC). The sample included 35 PD patients and 26 healthy controls (HC). Cognitive assessment followed an extensive neuropsychological battery. For resting-state functional MRI (rs-fMRI) analysis, independent component analysis (ICA) was performed and components were located in 7 networks: Subcortical (SC), Auditory (AUD), Somatomotor (SM), visual (VI), cognitive-control (CC), default-mode (DMN), and cerebellar (CB). Dynamic FC analysis was performed using the GIFT toolbox. FC differences between groups in each FC state were analysed with the network-based statistic (NBS) approach. Finally, a graph-theoretical analysis for local/global parameters was performed. The whole sample showed 2 dynamic FC states during the rs-fMRI. PD-MCI patients showed decreased mean dwell time in the hypo-connectivity state (p = 0.030) and showed increased number of state transitions (p = 0.007) compared with the HC. In addition, in the hypo-connectivity state, PD-MCI patients showed reduced inter-network FC between the SM-CC, SM-VI, SM-AUD, CC-VI and SC-DMN compared with the HC (p < 0.05-FDR). These FC alterations in PD-MCI were accompanied by graph-topological alterations in nodes located in the SM network (p < 0.001). In contrast, no differences were found between the PD-NC and HC. Findings suggest the presence of dynamic functional brain deteriorations in PD-MCI that are not present in PD-NC, showing the PD-MCI group dynamic FC dysfunctions, reduced FC mostly between SM-CC networks and graph-topological deteriorations in the SM network. A dynamic FC approach could be helpful to understand cognitive deterioration in PD. FAU - Diez-Cirarda, Maria AU - Diez-Cirarda M AD - Department of Methods and Experimental Psychology, Faculty of Psychology and Education, University of Deusto, Bilbao, Basque Country, Spain. Electronic address: maria.dcirarda@deusto.es. FAU - Strafella, Antonio P AU - Strafella AP AD - Research Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada; Division of Brain, Imaging and Behaviour - Systems Neuroscience, Krembil Research Institute, UHN, University of Toronto, Ontario, Canada. Electronic address: Antonio.Strafella@camh.ca. FAU - Kim, Jinhee AU - Kim J AD - Research Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada; Division of Brain, Imaging and Behaviour - Systems Neuroscience, Krembil Research Institute, UHN, University of Toronto, Ontario, Canada. Electronic address: jin-hee.kim@camhpet.ca. FAU - Pena, Javier AU - Pena J AD - Department of Methods and Experimental Psychology, Faculty of Psychology and Education, University of Deusto, Bilbao, Basque Country, Spain. Electronic address: javier.pena@deusto.es. FAU - Ojeda, Natalia AU - Ojeda N AD - Department of Methods and Experimental Psychology, Faculty of Psychology and Education, University of Deusto, Bilbao, Basque Country, Spain. Electronic address: nojeda@deusto.es. FAU - Cabrera-Zubizarreta, Alberto AU - Cabrera-Zubizarreta A AD - OSATEK, MR Unit, Hospital of Galdakao, Galdakao, Basque Country, Spain. Electronic address: acabrera@osatek.net. FAU - Ibarretxe-Bilbao, Naroa AU - Ibarretxe-Bilbao N AD - Department of Methods and Experimental Psychology, Faculty of Psychology and Education, University of Deusto, Bilbao, Basque Country, Spain. Electronic address: naroa.ibarretxe@deusto.es. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Research Support, U.S. Gov't, Non-P.H.S. DEP - 20171209 PL - Netherlands TA - Neuroimage Clin JT - NeuroImage. Clinical JID - 101597070 RN - S88TT14065 (Oxygen) SB - IM MH - Aged MH - Brain/diagnostic imaging/*physiopathology MH - *Brain Mapping MH - Cognition Disorders/complications/*pathology MH - Female MH - Humans MH - Image Processing, Computer-Assisted MH - Magnetic Resonance Imaging MH - Male MH - Middle Aged MH - Neural Pathways/diagnostic imaging/*physiopathology MH - Neuropsychological Tests MH - Nonlinear Dynamics MH - Oxygen/blood MH - Parkinson Disease/complications/*pathology MH - Severity of Illness Index PMC - PMC5842729 OTO - NOTNLM OT - Dynamic functional connectivity OT - Graph theory OT - Mild cognitive impairment OT - Networks OT - PD-MCI OT - Parkinson's disease EDAT- 2018/03/13 06:00 MHDA- 2019/01/31 06:00 PMCR- 2017/12/09 CRDT- 2018/03/13 06:00 PHST- 2017/07/14 00:00 [received] PHST- 2017/11/24 00:00 [revised] PHST- 2017/12/07 00:00 [accepted] PHST- 2018/03/13 06:00 [entrez] PHST- 2018/03/13 06:00 [pubmed] PHST- 2019/01/31 06:00 [medline] PHST- 2017/12/09 00:00 [pmc-release] AID - S2213-1582(17)30318-2 [pii] AID - 10.1016/j.nicl.2017.12.013 [doi] PST - epublish SO - Neuroimage Clin. 2017 Dec 9;17:847-855. doi: 10.1016/j.nicl.2017.12.013. eCollection 2018.