PMID- 29529550
OWN - NLM
STAT- MEDLINE
DCOM- 20180906
LR  - 20181202
IS  - 1573-2517 (Electronic)
IS  - 0165-0327 (Linking)
VI  - 234
DP  - 2018 Jul
TI  - Effects of transcranial direct current stimulation for treating depression: A 
      modeling study.
PG  - 164-173
LID - S0165-0327(17)32474-6 [pii]
LID - 10.1016/j.jad.2018.02.077 [doi]
AB  - BACKGROUND: Transcranial direct current stimulation (tDCS) above the left 
      dorsolateral prefrontal cortex (lDLPFC) has been widely used to improve symptoms 
      of major depressive disorder (MDD). However, the effects of different stimulation 
      protocols in the entire frontal lobe have not been investigated in a large sample 
      including patient data. METHODS: We used 38 head models created from structural 
      magnetic resonance imaging data of 19 healthy adults and 19 MDD patients and 
      applied computational modeling to simulate the spatial distribution of 
      tDCS-induced electric fields (EFs) in 20 frontal regions. We evaluated effects of 
      seven bipolar and two multi-electrode 4 x 1 tDCS protocols. RESULTS: For bipolar 
      montages, EFs were of comparable strength in the lDLPFC and in the medial 
      prefrontal cortex (MPFC). Depending on stimulation parameters, EF cortical maps 
      varied to a considerable degree, but were found to be similar in controls and 
      patients. 4 x 1 montages produced more localized, albeit weaker effects. 
      LIMITATIONS: White matter anisotropy was not modeled. The relationship between EF 
      strength and clinical response to tDCS could not be evaluated. CONCLUSIONS: In 
      addition to lDLPFC stimulation, excitability changes in the MPFC should also be 
      considered as a potential mechanism underlying clinical efficacy of bipolar 
      montages. MDD-associated anatomical variations are not likely to substantially 
      influence current flow. Individual modeling of tDCS protocols can substantially 
      improve cortical targeting. We make recommendations for future research to 
      explicitly test the contribution of lDLPFC vs. MPFC stimulation to therapeutic 
      outcomes of tDCS in this disorder.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Csifcsak, Gabor
AU  - Csifcsak G
AD  - Department of Psychology, UiT The Arctic University of Norway, Tromso, Norway. 
      Electronic address: gabor.csifcsak@uit.no.
FAU - Boayue, Nya Mehnwolo
AU  - Boayue NM
AD  - Department of Psychology, UiT The Arctic University of Norway, Tromso, Norway.
FAU - Puonti, Oula
AU  - Puonti O
AD  - Center for Magnetic Resonance, Department of Electrical Engineering, Technical 
      University of Denmark, Kgs Lyngby, Denmark; Danish Research Centre for Magnetic 
      Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen 
      University Hospital Hvidovre, Copenhagen, Denmark.
FAU - Thielscher, Axel
AU  - Thielscher A
AD  - Center for Magnetic Resonance, Department of Electrical Engineering, Technical 
      University of Denmark, Kgs Lyngby, Denmark; Danish Research Centre for Magnetic 
      Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen 
      University Hospital Hvidovre, Copenhagen, Denmark.
FAU - Mittner, Matthias
AU  - Mittner M
AD  - Department of Psychology, UiT The Arctic University of Norway, Tromso, Norway.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180228
PL  - Netherlands
TA  - J Affect Disord
JT  - Journal of affective disorders
JID - 7906073
SB  - IM
MH  - Adult
MH  - Computer Simulation
MH  - Depression/*therapy
MH  - Depressive Disorder, Major/therapy
MH  - Female
MH  - Frontal Lobe/physiology
MH  - Humans
MH  - Male
MH  - *Models, Theoretical
MH  - Prefrontal Cortex/*physiology
MH  - Transcranial Direct Current Stimulation/*methods
OTO - NOTNLM
OT  - Computational modeling
OT  - Depression
OT  - Dorsolateral prefrontal cortex
OT  - Medial prefrontal cortex
OT  - Transcranial direct current stimulation
OT  - tDCS
EDAT- 2018/03/13 06:00
MHDA- 2018/09/07 06:00
CRDT- 2018/03/13 06:00
PHST- 2017/12/01 00:00 [received]
PHST- 2018/02/01 00:00 [revised]
PHST- 2018/02/25 00:00 [accepted]
PHST- 2018/03/13 06:00 [pubmed]
PHST- 2018/09/07 06:00 [medline]
PHST- 2018/03/13 06:00 [entrez]
AID - S0165-0327(17)32474-6 [pii]
AID - 10.1016/j.jad.2018.02.077 [doi]
PST - ppublish
SO  - J Affect Disord. 2018 Jul;234:164-173. doi: 10.1016/j.jad.2018.02.077. Epub 2018 
      Feb 28.