PMID- 29529552
OWN - NLM
STAT- MEDLINE
DCOM- 20180906
LR  - 20181202
IS  - 1573-2517 (Electronic)
IS  - 0165-0327 (Linking)
VI  - 234
DP  - 2018 Jul
TI  - Does ceasing exercise induce depressive symptoms? A systematic review of 
      experimental trials including immunological and neurogenic markers.
PG  - 180-192
LID - S0165-0327(17)31749-4 [pii]
LID - 10.1016/j.jad.2018.02.058 [doi]
AB  - BACKGROUND: Regular exercise in adults improves depressive symptoms (DS) and 
      major depressive disorder (MDD), however the clinical effects of ceasing exercise 
      are largely unknown. METHODS: Seven databases were searched from inception to 
      December 2017. Eligibility criteria included English language studies 
      investigating the effects of ceasing exercise on DS or MDD in regularly active 
      adults with or without prior DS or MDD. Blood based markers related to exercise 
      cessation (EC) were assessed, if recorded. Studies investigating exercise 
      follow-up periods were excluded. RESULTS: No studies investigated EC in MDD. Six 
      studies including two RCTS and three studies investigating neurogenic and immune 
      biological markers associated with DS met inclusion criteria (152 healthy adults, 
      females n = 50/32.89%). Compared to baseline, EC increased DS after three days, 
      one week, and two weeks. Female participants had significantly more DS than male 
      participants. Following EC, no changes in brain derived neurotrophic factor 
      (BDNF) or tumour necrosis factor alpha (TNF) were evident, however C-reactive 
      protein (CRP) at week one and interleukin 6 (IL6) at week two were reduced. 
      LIMITATIONS: Quality concerns including risks of attrition and reporting bias 
      limit our confidence in these results. CONCLUSIONS: Ceasing regular exercise 
      increases DS in healthy adults, with greater DS in females than males. Contrary 
      to the cytokine/inflammatory hypothesis of depression, DS were associated with 
      reduced CRP and IL6 and without increased TNF. High quality trials are needed to 
      extend this field of research in both healthy and MDD populations.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Morgan, Julie A
AU  - Morgan JA
AD  - The University of Adelaide, Adelaide Medical School, Discipline of Psychiatry, 
      Adelaide, Australia.
FAU - Olagunju, Andrew T
AU  - Olagunju AT
AD  - The University of Adelaide, Adelaide Medical School, Discipline of Psychiatry, 
      Adelaide, Australia.
FAU - Corrigan, Frances
AU  - Corrigan F
AD  - The University of Adelaide, Adelaide Medical School, Discipline of Anatomy and 
      Pathology, Adelaide, Australia.
FAU - Baune, Bernhard T
AU  - Baune BT
AD  - The University of Adelaide, Adelaide Medical School, Discipline of Psychiatry, 
      Adelaide, Australia. Electronic address: Bernhard.Baune@adelaide.edu.au.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PT  - Systematic Review
DEP - 20180224
PL  - Netherlands
TA  - J Affect Disord
JT  - Journal of affective disorders
JID - 7906073
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Interleukin-6)
RN  - 0 (TNF protein, human)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adult
MH  - Biomarkers/blood
MH  - Brain-Derived Neurotrophic Factor/blood
MH  - Depressive Disorder, Major/*immunology/physiopathology/*prevention & control
MH  - Exercise/*physiology
MH  - Exercise Therapy/methods
MH  - Female
MH  - Humans
MH  - Interleukin-6/blood
MH  - Male
MH  - Neurogenesis/*immunology
MH  - Tumor Necrosis Factor-alpha/blood
OTO - NOTNLM
OT  - Depression
OT  - Exercise
OT  - Inflammation
OT  - Mental disorders
OT  - Neurogenesis
OT  - Neuroimmunomodulation
EDAT- 2018/03/13 06:00
MHDA- 2018/09/07 06:00
CRDT- 2018/03/13 06:00
PHST- 2017/08/19 00:00 [received]
PHST- 2018/02/01 00:00 [revised]
PHST- 2018/02/19 00:00 [accepted]
PHST- 2018/03/13 06:00 [pubmed]
PHST- 2018/09/07 06:00 [medline]
PHST- 2018/03/13 06:00 [entrez]
AID - S0165-0327(17)31749-4 [pii]
AID - 10.1016/j.jad.2018.02.058 [doi]
PST - ppublish
SO  - J Affect Disord. 2018 Jul;234:180-192. doi: 10.1016/j.jad.2018.02.058. Epub 2018 
      Feb 24.