PMID- 29530566
OWN - NLM
STAT- MEDLINE
DCOM- 20190923
LR  - 20190923
IS  - 1097-685X (Electronic)
IS  - 0022-5223 (Linking)
VI  - 156
IP  - 1
DP  - 2018 Jul
TI  - Heart failure with preserved ejection fraction as an independent risk factor of 
      mortality after cardiothoracic surgery.
PG  - 188-193.e2
LID - S0022-5223(18)30363-5 [pii]
LID - 10.1016/j.jtcvs.2018.02.011 [doi]
AB  - BACKGROUND: The prognostic role of heart failure with preserved ejection fraction 
      (HFpEF) remains unclear. This study aimed to assess HFpEF prognostic value after 
      cardiothoracic surgery, adjusting for European System for Cardiac Operative Risk 
      (EuroSCORE II) criteria. METHODS: Patients with left ventricular ejection 
      fraction (LVEF) >/= 50% undergoing cardiothoracic surgery between 2012 and 2016 
      were included. Patients with HFpEF were compared to control patients with LVEF >/= 
      50%. HFpEF was defined following 2016 European Society of Cardiology guidelines: 
      LVEF >/= 50%, symptomatic HF with New York Heart Association (NYHA) class 2 or 
      greater, elevated brain natriuretic peptide (BNP) and relevant echocardiographic 
      findings (LV hypertrophy, LA enlargement, or diastolic filling anomaly). The 
      primary endpoint was in-hospital mortality, and the secondary endpoint was 
      postoperative shock. Multivariate analyses were performed to determine mortality 
      and shock risk-factors. RESULTS: Among 1743 patients, 427 (24.5%) presented 
      HFpEF. HFpEF was highly associated with in-hospital mortality (hazard 
      ratio = 1.86; 95% confidence interval [CI], 1.16-2.98; P = .01). This association 
      remained independent when adjusting for EuroSCORE II (adjusted hazard 
      ratio = 1.6; 95% CI, 1.0-2.6; P = .049). Postoperative shock occurred more in 
      HFpEF than in control patients (17.8% vs 6.7%; P < .001). HFpEF was an 
      independent risk factor of postoperative shock (adjusted odds ratio = 2.9; 95% 
      CI, 1.5-3.0; P < .001). CONCLUSIONS: HFpEF was an independent risk-factor of 
      mortality and postoperative shock after cardiothoracic surgery, after adjustment 
      regarding EuroSCORE II.
CI  - Copyright (c) 2018 The American Association for Thoracic Surgery. Published by 
      Elsevier Inc. All rights reserved.
FAU - Nguyen, Lee S
AU  - Nguyen LS
AD  - CMC Ambroise Pare, Critical Care Medicine Department, Neuilly-sur-Seine, France; 
      AP-HP, Pitie-Salpetriere Hospital, Clinical Investigation Center-Paris-Est, 
      Paris, France. Electronic address: nguyen.lee@icloud.com.
FAU - Baudinaud, Pierre
AU  - Baudinaud P
AD  - CMC Ambroise Pare, Critical Care Medicine Department, Neuilly-sur-Seine, France.
FAU - Brusset, Alain
AU  - Brusset A
AD  - CMC Ambroise Pare, Critical Care Medicine Department, Neuilly-sur-Seine, France.
FAU - Nicot, Florence
AU  - Nicot F
AD  - CMC Ambroise Pare, Critical Care Medicine Department, Neuilly-sur-Seine, France.
FAU - Pechmajou, Louis
AU  - Pechmajou L
AD  - AP-HP, Pitie-Salpetriere Hospital, Clinical Investigation Center-Paris-Est, 
      Paris, France.
FAU - Salem, Joe-Elie
AU  - Salem JE
AD  - AP-HP, Mondor Hospital, Cardiology Department, Creteil, France.
FAU - Estagnasie, Philippe
AU  - Estagnasie P
AD  - CMC Ambroise Pare, Critical Care Medicine Department, Neuilly-sur-Seine, France.
FAU - Squara, Pierre
AU  - Squara P
AD  - CMC Ambroise Pare, Critical Care Medicine Department, Neuilly-sur-Seine, France.
LA  - eng
PT  - Journal Article
DEP - 20180213
PL  - United States
TA  - J Thorac Cardiovasc Surg
JT  - The Journal of thoracic and cardiovascular surgery
JID - 0376343
SB  - IM
CIN - J Thorac Cardiovasc Surg. 2018 Jul;156(1):194-195. PMID: 29576259
MH  - Aged
MH  - Aged, 80 and over
MH  - Cardiac Surgical Procedures/adverse effects/*mortality
MH  - Cardiopulmonary Bypass/adverse effects/mortality
MH  - Databases, Factual
MH  - Female
MH  - Heart Failure/diagnosis/*mortality/*physiopathology
MH  - Hospital Mortality
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Registries
MH  - Risk Assessment
MH  - Risk Factors
MH  - Shock, Cardiogenic/diagnosis/etiology/*mortality/physiopathology
MH  - *Stroke Volume
MH  - Time Factors
MH  - Treatment Outcome
MH  - *Ventricular Function, Left
OTO - NOTNLM
OT  - cardiac surgery
OT  - heart failure with preserved ejection fraction
OT  - perioperative management
OT  - risk evaluation
OT  - risk-score
EDAT- 2018/03/14 06:00
MHDA- 2019/09/24 06:00
CRDT- 2018/03/14 06:00
PHST- 2017/07/18 00:00 [received]
PHST- 2018/01/21 00:00 [revised]
PHST- 2018/02/02 00:00 [accepted]
PHST- 2018/03/14 06:00 [pubmed]
PHST- 2019/09/24 06:00 [medline]
PHST- 2018/03/14 06:00 [entrez]
AID - S0022-5223(18)30363-5 [pii]
AID - 10.1016/j.jtcvs.2018.02.011 [doi]
PST - ppublish
SO  - J Thorac Cardiovasc Surg. 2018 Jul;156(1):188-193.e2. doi: 
      10.1016/j.jtcvs.2018.02.011. Epub 2018 Feb 13.