PMID- 29530824
OWN - NLM
STAT- MEDLINE
DCOM- 20180720
LR  - 20180720
IS  - 1532-0456 (Print)
IS  - 1532-0456 (Linking)
VI  - 209
DP  - 2018 Jul
TI  - Toxicological effects of trichlorfon on hematological and biochemical parameters 
      in Cyprinus carpio L. following thermal stress.
PG  - 18-27
LID - S1532-0456(18)30017-6 [pii]
LID - 10.1016/j.cbpc.2018.03.001 [doi]
AB  - Trichlorfon is a moderately toxic organophosphate pesticide that is widely used 
      in aquaculture. This study investigated the effects of trichlorfon on 
      hematological parameters, biochemical factors, and stress reaction in Cyprinus 
      carpio L. The fish were exposed to acute concentrations of trichlorfon (0, 0.5, 
      1.0, 2.0, and 4.0 mg L(-1)) at 25  degrees C and 15  degrees C for 1 and 2 weeks, after which 
      several parameters were evaluated to assess the effects of the pesticide. 
      Significant decreases were observed in red blood cell (RBC) Count, hemoglobin 
      (Hb) level, hematocrit (Ht), and plasma protein levels after each exposure 
      period. In contrast, notable increases in mean corpuscular volume (MCV), mean 
      cell hemoglobin (MCH), calcium, and glucose levels were observed in the 
      trichlorfon-treated groups. Additionally, there were significant increases in the 
      plasma levels of glutamate-oxaloacetate transaminase (GOT), glutamate-pyruvate 
      transaminase (GPT), and alkaline phosphatase (ALP) following the exposure to 
      trichlorfon. Furthermore, the results showed a relationship between toxic stress 
      and increment in HSP70 and cytochrome P450 1A (CYP1A) expression over time. Ht, 
      MCV, MCH, and the value of other biochemical parameters were quite lower at 15  degrees C 
      than their corresponding values were at 25  degrees C, which indicated the decreased 
      physical activity at 15  degrees C. The results of the present work indicate that acute 
      exposure to trichlorfon and thermal stimulus could damage erythropoietic tissue. 
      Additionally, hepatocytes function and physiological mechanisms could be 
      impaired. Ht, glucose, GOT, GPT, HSP70, and CYP1A levels might be useful 
      biomarkers of trichlorfon toxicity in contaminated aquatic ecosystems.
CI  - Copyright (c) 2018 Elsevier Inc. All rights reserved.
FAU - Woo, Soo Ji
AU  - Woo SJ
AD  - Department of Aquatic Life Medicine, Pukyong National University, Busan 48513, 
      Republic of Korea.
FAU - Kim, Na Young
AU  - Kim NY
AD  - Pathology Research Division, National Institute of Fisheries Science (NIFS), 
      Busan 46083, Republic of Korea.
FAU - Kim, Shin Hu
AU  - Kim SH
AD  - Department of Aquatic Life Medicine, Pukyong National University, Busan 48513, 
      Republic of Korea.
FAU - Ahn, Sang Jung
AU  - Ahn SJ
AD  - Fisheries R&D Management Center, Korea Institute of Marine Science & Technology 
      Promotion (KIMST), Seoul 06775, Republic of Korea.
FAU - Seo, Jung Soo
AU  - Seo JS
AD  - Aquatic Disease Control Division, National Institute of Fisheries Science (NIFS), 
      Busan 46083, Republic of Korea.
FAU - Jung, Sung Hee
AU  - Jung SH
AD  - Pathology Research Division, National Institute of Fisheries Science (NIFS), 
      Busan 46083, Republic of Korea.
FAU - Cho, Mi Young
AU  - Cho MY
AD  - Pathology Research Division, National Institute of Fisheries Science (NIFS), 
      Busan 46083, Republic of Korea.
FAU - Chung, Joon Ki
AU  - Chung JK
AD  - Department of Aquatic Life Medicine, Pukyong National University, Busan 48513, 
      Republic of Korea. Electronic address: jkchung@pknu.ac.kr.
LA  - eng
PT  - Journal Article
DEP - 20180310
PL  - United States
TA  - Comp Biochem Physiol C Toxicol Pharmacol
JT  - Comparative biochemistry and physiology. Toxicology & pharmacology : CBP
JID - 100959500
RN  - 0 (Cytochrome P-450 Enzyme Inducers)
RN  - 0 (Environmental Biomarkers)
RN  - 0 (Fish Proteins)
RN  - 0 (HSP70 Heat-Shock Proteins)
RN  - 0 (Pesticides)
RN  - 0 (Water Pollutants, Chemical)
RN  - DBF2DG4G2K (Trichlorfon)
RN  - EC 1.14.14.1 (Cytochrome P450 Family 1)
RN  - EC 2.6.1.1 (Aspartate Aminotransferases)
RN  - EC 2.6.1.2 (Alanine Transaminase)
SB  - IM
MH  - Alanine Transaminase/blood/metabolism
MH  - Animals
MH  - Aquaculture
MH  - Aspartate Aminotransferases/blood/metabolism
MH  - Carps/blood/growth & development/*physiology
MH  - Cytochrome P-450 Enzyme Inducers/toxicity
MH  - Cytochrome P450 Family 1/genetics/metabolism
MH  - Environmental Biomarkers/drug effects
MH  - Erythrocyte Indices/drug effects
MH  - Fish Proteins/blood/chemistry/genetics/metabolism
MH  - Gene Expression Regulation, Developmental/drug effects
MH  - HSP70 Heat-Shock Proteins/agonists/antagonists & inhibitors/genetics/metabolism
MH  - Heat-Shock Response/*drug effects
MH  - Hot Temperature
MH  - Liver/*drug effects/enzymology/metabolism
MH  - Osmolar Concentration
MH  - Pesticides/*toxicity
MH  - Republic of Korea
MH  - Toxicity Tests, Acute
MH  - Trichlorfon/*toxicity
MH  - Water Pollutants, Chemical/*toxicity
MH  - Water Pollution/*adverse effects
OTO - NOTNLM
OT  - Common carp
OT  - Cytochrome P450 1A
OT  - Glutamate-oxaloacetate transaminase
OT  - Glutamate-pyruvate transaminase
OT  - Heat shock protein 70
OT  - Hematocrit
OT  - Hemoglobin
OT  - Trichlorfon
EDAT- 2018/03/14 06:00
MHDA- 2018/07/22 06:00
CRDT- 2018/03/14 06:00
PHST- 2017/11/20 00:00 [received]
PHST- 2018/02/14 00:00 [revised]
PHST- 2018/03/08 00:00 [accepted]
PHST- 2018/03/14 06:00 [pubmed]
PHST- 2018/07/22 06:00 [medline]
PHST- 2018/03/14 06:00 [entrez]
AID - S1532-0456(18)30017-6 [pii]
AID - 10.1016/j.cbpc.2018.03.001 [doi]
PST - ppublish
SO  - Comp Biochem Physiol C Toxicol Pharmacol. 2018 Jul;209:18-27. doi: 
      10.1016/j.cbpc.2018.03.001. Epub 2018 Mar 10.