PMID- 29532458 OWN - NLM STAT- MEDLINE DCOM- 20190710 LR - 20190710 IS - 1600-0447 (Electronic) IS - 0001-690X (Linking) VI - 137 IP - 5 DP - 2018 May TI - Brain-derived neurotrophic factor (BDNF) in children with ASD and their parents: a 3-year follow-up. PG - 433-441 LID - 10.1111/acps.12872 [doi] AB - OBJECTIVE: Several lines of evidence point to a probable relationship between brain-derived neurotrophic factor (BDNF) and autism spectrum disorder (ASD), but studies have yielded inconsistent findings on the BDNF serum level in ASD. The study aimed to assess those levels in children with ASD and their families. METHOD: BDNF serum levels were measured in 45 ASD children without intellectual disability (ID) and allergies, age 30-42 months and age-matched normal controls. BDNF serum levels in the parents of the ASD subjects were compared to normal controls. BDNF serum levels in the ASD subjects were followed up for 3 years and correlated with adaptive functioning changes. RESULTS: BDNF serum levels were measured to be lower in children with ASD and independent of all the major baseline characteristics of the subjects. Having a child with ASD raises the BDNF levels in parents comparing to controls. Prospectively, no correlation between the change of BDNF variables in time and the change of the Vineland scores was found. CONCLUSIONS: Our results contradict those from recent published meta-analyses with the age, the presence of ID and allergies being possible contributing factors. The parents' data indeed point to a role of BDNF in the pathophysiology of ASD. CI - (c) 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. FAU - Francis, K AU - Francis K AUID- ORCID: 0000-0002-1352-1732 AD - 2nd Department of Psychiatry, Athens University Medical School, 'Attikon' General Hospital, Athens, Greece. AD - Child and Adolescent Psychiatric Unit, Kuwait Centre for Mental Health, Kuwait, Kuwait. FAU - Dougali, A AU - Dougali A AD - 2nd Department of Psychiatry, Athens University Medical School, 'Attikon' General Hospital, Athens, Greece. FAU - Sideri, K AU - Sideri K AD - Allergy Research Center, Attikon General Hospital, University of Athens Medical School, Athens, Greece. FAU - Kroupis, C AU - Kroupis C AD - Laboratory of Clinical Biochemistry, Attikon University Hospital, Medical School, University of Athens, Athens, Greece. FAU - Vasdekis, V AU - Vasdekis V AD - Department of Statistics, Athens University of Economic and Business, Athens, Greece. FAU - Dima, K AU - Dima K AD - Laboratory of Clinical Biochemistry, Attikon University Hospital, Medical School, University of Athens, Athens, Greece. FAU - Douzenis, A AU - Douzenis A AD - 2nd Department of Psychiatry, Athens University Medical School, 'Attikon' General Hospital, Athens, Greece. LA - eng PT - Journal Article DEP - 20180313 PL - United States TA - Acta Psychiatr Scand JT - Acta psychiatrica Scandinavica JID - 0370364 RN - 0 (Biomarkers) RN - 0 (Brain-Derived Neurotrophic Factor) RN - 7171WSG8A2 (BDNF protein, human) SB - IM MH - Adult MH - Autism Spectrum Disorder/*blood MH - Biomarkers/blood MH - Brain-Derived Neurotrophic Factor/*blood MH - Child MH - Child, Preschool MH - Female MH - Follow-Up Studies MH - Humans MH - Male MH - *Parents OTO - NOTNLM OT - autism spectrum disorder (ASD) OT - brain-derived neurotrophic factor (BDNF) OT - follow-up OT - parents' correlates EDAT- 2018/03/14 06:00 MHDA- 2019/07/11 06:00 CRDT- 2018/03/14 06:00 PHST- 2018/02/13 00:00 [accepted] PHST- 2018/03/14 06:00 [pubmed] PHST- 2019/07/11 06:00 [medline] PHST- 2018/03/14 06:00 [entrez] AID - 10.1111/acps.12872 [doi] PST - ppublish SO - Acta Psychiatr Scand. 2018 May;137(5):433-441. doi: 10.1111/acps.12872. Epub 2018 Mar 13.