PMID- 29532763
OWN - NLM
STAT- MEDLINE
DCOM- 20190725
LR  - 20190725
IS  - 1875-5992 (Electronic)
IS  - 1871-5206 (Linking)
VI  - 18
IP  - 8
DP  - 2018
TI  - Co-delivery of Doxorubicin and D-alpha-Tocopherol Polyethylene Glycol 1000 Succinate 
      by Magnetic Nanoparticles.
PG  - 1138-1147
LID - 10.2174/1871520618666180313154724 [doi]
AB  - BACKGROUND: Although conventional chemotherapy is the most common method for 
      cancer treatment, it has several side effects such as neuropathy, alopecia and 
      cardiotoxicity. Since the drugs are given to body systemically, normal cells are 
      also affected, just like cancer cells. However, in recent years, targeted drug 
      delivery has been developed to overcome these drawbacks. OBJECTIVE: The aim of 
      this study was targeted co-delivery of doxorubicin (Dox) which is an anticancer 
      agent and D-alpha-Tocopherol polyethylene glycol 1000 succinate (vitamin E TPGS or 
      simply TPGS) to breast cancer cells. For this purpose, Magnetic Nanoparticles 
      (MNPs) were synthesized and coated with Oleic Acid (OA). Coated nanoparticles 
      were encapsulated in Poly Lactic-co-Glycolic Acid (PLGA) and TPGS polymers and 
      loaded with Dox. The Nanoparticles (NPs) were characterized by Fourier Transform 
      Infrared (FTIR) spectroscopy, zetapotential analysis, Dynamic Light Scattering 
      (DLS) analysis, Thermal Gravimetric Analysis (TGA) and Scanning Electron 
      Microscope (SEM) analysis. RESULTS: The results showed that NPs were spherical, 
      superparamagnetic and in the desired range for use in drug targeting. The 
      targetability of NPs was confirmed. Moreover, TPGS and Dox loading was shown by 
      TGA and FTIR analyses. NPs were internalized by cells and the cytotoxic effect of 
      drug loaded NPs on sensitive (MCF-7) and drug-resistant (MCF-7/Dox) cells were 
      examined. It was seen that the presence of TPGS increased cytotoxicity 
      significantly. TPGS also enhanced drug loading efficiency, release rate, cellular 
      internalization. In MCF- 7/Dox cells, the drug resistance seems to be decreased 
      when Dox is loaded onto TPGS containing NPs. CONCLUSION: This magnetic PLGA 
      nanoparticle system is important for new generation targeted chemotherapy and 
      could be used for breast cancer treatment after in vivo tests.
CI  - Copyright(c) Bentham Science Publishers; For any queries, please email at 
      epub@benthamscience.net.
FAU - Metin, Esra
AU  - Metin E
AD  - Middle East Technical University, Department of Biotechnology, Ankara, Turkey.
FAU - Mutlu, Pelin
AU  - Mutlu P
AD  - Middle East Technical University, Central Laboratory, Molecular Biology and 
      Biotechnology R&D, Ankara, Turkey.
FAU - Gunduz, Ufuk
AU  - Gunduz U
AD  - Middle East Technical University, Department of Biology, Ankara, Turkey.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Anticancer Agents Med Chem
JT  - Anti-cancer agents in medicinal chemistry
JID - 101265649
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Magnetite Nanoparticles)
RN  - 0 (Succinates)
RN  - 3WJQ0SDW1A (Polyethylene Glycols)
RN  - 80168379AG (Doxorubicin)
RN  - U076Q6Q621 (polyethylene glycol 1000)
MH  - Antineoplastic Agents/chemistry/*pharmacology
MH  - Cell Proliferation/drug effects
MH  - Dose-Response Relationship, Drug
MH  - Doxorubicin/chemistry/*pharmacology
MH  - *Drug Delivery Systems
MH  - Drug Liberation
MH  - Drug Screening Assays, Antitumor
MH  - Humans
MH  - MCF-7 Cells
MH  - Magnetite Nanoparticles/*chemistry
MH  - Molecular Structure
MH  - Particle Size
MH  - Polyethylene Glycols/chemistry/*pharmacology
MH  - Structure-Activity Relationship
MH  - Succinates/chemistry/*pharmacology
MH  - Surface Properties
OTO - NOTNLM
OT  - Breast cancer
OT  - MNP
OT  - PLGA
OT  - doxorubicin
OT  - targeted co-delivery
OT  - vitamin E TPGS.
EDAT- 2018/03/14 06:00
MHDA- 2019/07/26 06:00
CRDT- 2018/03/14 06:00
PHST- 2017/09/19 00:00 [received]
PHST- 2018/03/02 00:00 [revised]
PHST- 2018/03/08 00:00 [accepted]
PHST- 2018/03/14 06:00 [pubmed]
PHST- 2019/07/26 06:00 [medline]
PHST- 2018/03/14 06:00 [entrez]
AID - ACAMC-EPUB-89090 [pii]
AID - 10.2174/1871520618666180313154724 [doi]
PST - ppublish
SO  - Anticancer Agents Med Chem. 2018;18(8):1138-1147. doi: 
      10.2174/1871520618666180313154724.