PMID- 29533052
OWN - NLM
STAT- MEDLINE
DCOM- 20191108
LR  - 20191108
IS  - 1764-1489 (Print)
IS  - 1764-1489 (Linking)
VI  - 50
IP  - 4
DP  - 2018 Jul
TI  - Histamine-release test in angioedema patients without urticaria - a retrospective 
      cohort study of 404 patients.
PG  - 163-168
LID - 10.23822/EurAnnACI.1764-1489.58 [doi]
AB  - A subset of patients with angioedema (AE) and urticaria has histamine releasing 
      autoantibodies. The histamine release test (HR-test) has been used as a tool in 
      chronic urticaria to define the autoimmune subgroup and may possibly guide the 
      clinician to a more personalized therapy, like omalizumab and cyclosporine. The 
      prevalence and value of positive histamine releasing autoantibodies in 
      monosymptomatic AE is sparsely described in the literature. The purpose of this 
      study was to report the prevalence of positive histamine releasing autoantibodies 
      in a cohort of patients with recurrent AE and evaluate the usefulness of this 
      test in AE patients. We performed a retrospective cohort study of 612 patients 
      referred due to AE between 1995 and 2013. HR-test results were available in 404 
      patients. In the sub-group of patients with AE and urticaria, 17.3% had a 
      positive HR-test but only 4.3% of patients with mono-symptomatic AE had a 
      positive HR-test. No statistically significant treatment benefits of 
      antihistamines, corticosteroids or adrenaline were found comparing patients with 
      angioedema +/- urticaria based on the result of the HR-test (negative / 
      positive). Thus, the HR-test result cannot be used as predictor of the efficacy 
      of anti-allergic treatment.
FAU - Authried, G
AU  - Authried G
AD  - Department of Dermatology and Allergy Centre, Odense University Hospital, Odense, 
      Den-mark.
FAU - Prasad, S C
AU  - Prasad SC
AD  - Department of Dermatology and Allergy Centre, Odense University Hospital, Odense, 
      Den-mark.
FAU - Rasmussen, E R
AU  - Rasmussen ER
AD  - Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, 
      Rigshospitalet, University of Copenhagen, Kobenhavn, Denmark.
FAU - Bygum, A
AU  - Bygum A
AD  - Department of Dermatology and Allergy Centre, Odense University Hospital, Odense, 
      Den-mark.
LA  - eng
PT  - Journal Article
DEP - 20180219
PL  - Italy
TA  - Eur Ann Allergy Clin Immunol
JT  - European annals of allergy and clinical immunology
JID - 101466614
RN  - 0 (Adrenal Cortex Hormones)
RN  - 0 (Anti-Allergic Agents)
RN  - 0 (Autoantibodies)
RN  - 0 (Histamine Antagonists)
RN  - YKH834O4BH (Epinephrine)
SB  - IM
MH  - Adolescent
MH  - Adrenal Cortex Hormones/therapeutic use
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Angioedema/*diagnosis/*drug therapy
MH  - Anti-Allergic Agents/*therapeutic use
MH  - Autoantibodies/*immunology
MH  - Child
MH  - Child, Preschool
MH  - Epinephrine/therapeutic use
MH  - Female
MH  - Histamine Antagonists/therapeutic use
MH  - Histamine Release/*physiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Urticaria/*diagnosis
MH  - Young Adult
OTO - NOTNLM
OT  - adrenaline
OT  - antihistamines
OT  - corticosteroids
OT  - histamine-release test
OT  - monosymptomatic angioedema
OT  - urticaria
EDAT- 2018/03/14 06:00
MHDA- 2019/11/09 06:00
CRDT- 2018/03/14 06:00
PHST- 2018/03/14 06:00 [pubmed]
PHST- 2019/11/09 06:00 [medline]
PHST- 2018/03/14 06:00 [entrez]
AID - 10.23822/EurAnnACI.1764-1489.58 [doi]
PST - ppublish
SO  - Eur Ann Allergy Clin Immunol. 2018 Jul;50(4):163-168. doi: 
      10.23822/EurAnnACI.1764-1489.58. Epub 2018 Feb 19.