PMID- 29534355
OWN - NLM
STAT- MEDLINE
DCOM- 20180323
LR  - 20211204
IS  - 0529-5807 (Print)
IS  - 0529-5807 (Linking)
VI  - 47
IP  - 3
DP  - 2018 Mar 8
TI  - [Correlation between C-MYC protein expression and genetic abnormalities in 
      diffuse large B-cell lymphoma].
PG  - 172-175
LID - 10.3760/cma.j.issn.0529-5807.2018.03.005 [doi]
AB  - Objective: To study the correlation between expression of oncogene C-MYC protein 
      and gene abnormality in diffuse large B-cell lymphoma (DLBCL). Methods: The 
      expression of C-MYC protein and gene abnormality were detected by 
      immunohistochemistry and fluorescence in situ hybridization (FISH), respectively, 
      in 42 cases of paraffin-embedded DLBCL. All cases were collected at Department of 
      Pathology, Weifang People's Hospital during January 2015 to October 2016. 
      Results: The positive rate of C-MYC protein expression was 47.6% (20/42) and the 
      rate of abnormal C-MYC gene by FISH was 26.2%(11/42), including translocation 
      (23.8%, 10/42) and gene amplification (2.4%, 1/42). There was a close 
      relationship between the protein expression and gene translocation (chi(2)=11.813; 
      P=0.001) and gene translocation occurred primarily in GCB (chi(2)=4.029; P=0.045). 
      Conclusion: The high expression (>/=40%) of C-MYC protein is associated with its 
      gene translocation, suggesting that C-MYC protein detection can be used as a 
      surrogate marker for C-MYC gene translocation in DLBCL.
FAU - Yu, H
AU  - Yu H
AD  - Department of Pathology, Weifang Medical University, Shandong Province, Weifang 
      261053, China.
FAU - Wang, H
AU  - Wang H
FAU - Zhang, N
AU  - Zhang N
FAU - Gao, S M
AU  - Gao SM
FAU - Zhang, Y X
AU  - Zhang YX
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhonghua Bing Li Xue Za Zhi
JT  - Zhonghua bing li xue za zhi = Chinese journal of pathology
JID - 0005331
RN  - 0 (MAS1 protein, human)
RN  - 0 (Proto-Oncogene Mas)
RN  - 0 (Proto-Oncogene Proteins c-myc)
SB  - IM
MH  - Gene Amplification
MH  - *Genes, myc
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Lymphoma, Large B-Cell, Diffuse/*genetics/*metabolism
MH  - Proto-Oncogene Mas
MH  - Proto-Oncogene Proteins c-myc/*metabolism
MH  - Translocation, Genetic
OTO - NOTNLM
OT  - Gene amplification
OT  - Lymphoma, large B-cell, diffuse
OT  - Proto-oncogene proteins c-myc
EDAT- 2018/03/14 06:00
MHDA- 2018/03/24 06:00
CRDT- 2018/03/14 06:00
PHST- 2018/03/14 06:00 [entrez]
PHST- 2018/03/14 06:00 [pubmed]
PHST- 2018/03/24 06:00 [medline]
AID - 10.3760/cma.j.issn.0529-5807.2018.03.005 [doi]
PST - ppublish
SO  - Zhonghua Bing Li Xue Za Zhi. 2018 Mar 8;47(3):172-175. doi: 
      10.3760/cma.j.issn.0529-5807.2018.03.005.