PMID- 29534856 OWN - NLM STAT- MEDLINE DCOM- 20181211 LR - 20181211 IS - 1532-2955 (Electronic) IS - 1087-0792 (Linking) VI - 41 DP - 2018 Oct TI - Delayed sleep phase syndrome and bipolar disorder: Pathogenesis and available common biomarkers. PG - 133-140 LID - S1087-0792(17)30225-3 [pii] LID - 10.1016/j.smrv.2018.02.002 [doi] AB - Circadian rhythm disturbances are common in bipolar affective disorder (BD). Delayed sleep-wake phase syndrome (DSWPD) is the most prevalent circadian rhythm sleep-wake disorder (CRSWDs) and is frequently observed in BD. It is unclear whether DSWPD in BD is an independent process or is a consequence of BD. In this hypothetical review, we discuss the overlap between BD and DSWPD and potential common biomarkers for DSWPD and BD. The review will include a discussion of the genetics of DSWPD and BD. Biomarkers elucidating the pathophysiological processes occurring in these two disorders may offer insight into the etiology and prognosis of both conditions. CI - Copyright (c) 2018 Elsevier Ltd. All rights reserved. FAU - Talih, Farid AU - Talih F AD - Faculty of Medicine, American University of Beirut Medical Center, Beirut, Lebanon; Department of Psychiatry, American University of Beirut Medical Center, Beirut, Lebanon. Electronic address: ft10@aub.edu.lb. FAU - Gebara, Nour Y AU - Gebara NY AD - Faculty of Medicine, American University of Beirut Medical Center, Beirut, Lebanon. Electronic address: nyg00@mail.aub.edu. FAU - Andary, Farah S AU - Andary FS AD - Faculty of Medicine, American University of Beirut Medical Center, Beirut, Lebanon. FAU - Mondello, Stefania AU - Mondello S AD - Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy; Sleep Research Centre, Oasi Research Institute IRCCS, Troina, Italy. FAU - Kobeissy, Firas AU - Kobeissy F AD - Faculty of Medicine, American University of Beirut Medical Center, Beirut, Lebanon. FAU - Ferri, Raffaele AU - Ferri R AD - Sleep Research Centre, Oasi Research Institute IRCCS, Troina, Italy. LA - eng PT - Journal Article PT - Review DEP - 20180213 PL - England TA - Sleep Med Rev JT - Sleep medicine reviews JID - 9804678 RN - 0 (Biomarkers) SB - IM MH - Biomarkers MH - Bipolar Disorder/*complications/*physiopathology MH - Humans MH - Sleep Disorders, Circadian Rhythm/etiology/*physiopathology/psychology OTO - NOTNLM OT - Biomarkers OT - Bipolar disorder OT - Circadian rhythm sleep-wake disorders OT - Delayed sleep wake phase disorder OT - Melatonin OT - Mood disorder OT - Sleep disorders EDAT- 2018/03/15 06:00 MHDA- 2018/12/12 06:00 CRDT- 2018/03/15 06:00 PHST- 2016/10/19 00:00 [received] PHST- 2018/02/03 00:00 [revised] PHST- 2018/02/07 00:00 [accepted] PHST- 2018/03/15 06:00 [pubmed] PHST- 2018/12/12 06:00 [medline] PHST- 2018/03/15 06:00 [entrez] AID - S1087-0792(17)30225-3 [pii] AID - 10.1016/j.smrv.2018.02.002 [doi] PST - ppublish SO - Sleep Med Rev. 2018 Oct;41:133-140. doi: 10.1016/j.smrv.2018.02.002. Epub 2018 Feb 13.