PMID- 29534932
OWN - NLM
STAT- MEDLINE
DCOM- 20190906
LR  - 20190906
IS  - 1095-953X (Electronic)
IS  - 0969-9961 (Linking)
VI  - 114
DP  - 2018 Jun
TI  - Resveratrol, a natural polyphenol, prevents chemotherapy-induced cognitive 
      impairment: Involvement of cytokine modulation and neuroprotection.
PG  - 164-173
LID - S0969-9961(18)30072-X [pii]
LID - 10.1016/j.nbd.2018.03.006 [doi]
AB  - Chemotherapy-induced cognitive impairment, also known as "chemobrain," is a 
      common side effect. The purpose of this study was to examine whether resveratrol, 
      a natural polyphenol that has nootropic effects, could prevent chemobrain and its 
      underlying mechanisms. Mice received three injections of docetaxel, adriamycin, 
      and cyclophosphamide (DAC) in combination, a common chemotherapy regimen, at 
      two-day intervals within one week. Resveratrol (50 and 100 mg/kg per day) was 
      orally administered for three weeks, beginning one week before the DAC treatment. 
      Water maze test and manganese-enhanced magnetic resonance imaging were used to 
      evaluate animals' cognitive performance and brain neuronal activity, 
      respectively. Blood and brain tissues were collected for measurement of 
      cytokines, cytokine regulators, and biomarkers for neuroplasticity. DAC treatment 
      produced a striking cognitive impairment. Cotreatment with 100 mg/kg resveratrol 
      ameliorated DAC-induced cognitive impairment and decreases in prefrontal and 
      hippocampal neuronal activity. Mice co-treated with both doses of resveratrol 
      displayed significantly lower levels of the proinflammatory cytokines tumor 
      necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6), but markedly higher levels of 
      the anti-inflammatory cytokines IL-4 and IL-10 in several sera and brain tissues 
      than those co-treated with vehicle. Resveratrol modulated the cytokine-regulating 
      pathway peroxisome proliferator activated receptor (PPAR)-gamma/nuclear factor 
      kappa-light-chain-enhancer of activated B cells (NF-kappaB), and protected against 
      DAC-induced decreases in the expression of the neuroplasticity biomarkers, 
      brain-derived neurotrophic factor (BDNF), tropomyosin receptor kinase B (TrkB), 
      amino acid neurotransmitter receptors, and calmodulin-dependent protein kinase II 
      (CaMKII). These results demonstrate the efficacy of resveratrol in preventing 
      chemobrain and its association with cytokine modulation and neuroprotection.
CI  - Copyright (c) 2018 Elsevier Inc. All rights reserved.
FAU - Shi, Dong-Dong
AU  - Shi DD
AD  - School of Chinese Medicine, LKS Faculty of Medicine, The University of Hong Kong, 
      Hong Kong, China.
FAU - Dong, Celia M
AU  - Dong CM
AD  - Laboratory of Biomedical Imaging and Signal Processing, Department of Electrical 
      and Electronic Engineering, The University of Hong Kong, Hong Kong, China.
FAU - Ho, Leon C
AU  - Ho LC
AD  - Laboratory of Biomedical Imaging and Signal Processing, Department of Electrical 
      and Electronic Engineering, The University of Hong Kong, Hong Kong, China.
FAU - Lam, C T W
AU  - Lam CTW
AD  - School of Chinese Medicine, LKS Faculty of Medicine, The University of Hong Kong, 
      Hong Kong, China.
FAU - Zhou, Xi-Dan
AU  - Zhou XD
AD  - School of Chinese Medicine, LKS Faculty of Medicine, The University of Hong Kong, 
      Hong Kong, China.
FAU - Wu, Ed X
AU  - Wu EX
AD  - Laboratory of Biomedical Imaging and Signal Processing, Department of Electrical 
      and Electronic Engineering, The University of Hong Kong, Hong Kong, China.
FAU - Zhou, Zhong-Jun
AU  - Zhou ZJ
AD  - School of Biomedical Sciences, LKS Faculty of Medicine, The University of Hong 
      Kong, Hong Kong, China.
FAU - Wang, Xiao-Min
AU  - Wang XM
AD  - Department of Anesthesiology, LKS Faculty of Medicine, The University of Hong 
      Kong, Hong Kong, China.
FAU - Zhang, Zhang-Jin
AU  - Zhang ZJ
AD  - School of Chinese Medicine, LKS Faculty of Medicine, The University of Hong Kong, 
      Hong Kong, China. Electronic address: zhangzj@hku.hk.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180310
PL  - United States
TA  - Neurobiol Dis
JT  - Neurobiology of disease
JID - 9500169
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Antioxidants)
RN  - 0 (Cytokines)
RN  - 0 (Polyphenols)
RN  - Q369O8926L (Resveratrol)
SB  - IM
MH  - Animals
MH  - Antineoplastic Agents/*toxicity
MH  - Antioxidants/pharmacology/therapeutic use
MH  - Cognitive Dysfunction/chemically induced/*drug therapy/metabolism
MH  - Cytokines/*antagonists & inhibitors/metabolism
MH  - Female
MH  - Maze Learning/drug effects/physiology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Neuroprotection/*drug effects/physiology
MH  - Polyphenols/pharmacology/*therapeutic use
MH  - Resveratrol/pharmacology/*therapeutic use
OTO - NOTNLM
OT  - Chemobrain
OT  - Chemotherapy
OT  - Cognitive impairment
OT  - Cytokines
OT  - Neuroplasticity
OT  - Neuroprotection
OT  - Resveratrol
EDAT- 2018/03/15 06:00
MHDA- 2019/09/07 06:00
CRDT- 2018/03/15 06:00
PHST- 2018/01/23 00:00 [received]
PHST- 2018/03/06 00:00 [revised]
PHST- 2018/03/08 00:00 [accepted]
PHST- 2018/03/15 06:00 [pubmed]
PHST- 2019/09/07 06:00 [medline]
PHST- 2018/03/15 06:00 [entrez]
AID - S0969-9961(18)30072-X [pii]
AID - 10.1016/j.nbd.2018.03.006 [doi]
PST - ppublish
SO  - Neurobiol Dis. 2018 Jun;114:164-173. doi: 10.1016/j.nbd.2018.03.006. Epub 2018 
      Mar 10.