PMID- 29535036
OWN - NLM
STAT- MEDLINE
DCOM- 20190415
LR  - 20190415
IS  - 1878-4216 (Electronic)
IS  - 0278-5846 (Linking)
VI  - 91
DP  - 2019 Apr 20
TI  - Interactive effects of genetic polymorphisms and childhood adversity on brain 
      morphologic changes in depression.
PG  - 4-13
LID - S0278-5846(18)30049-6 [pii]
LID - 10.1016/j.pnpbp.2018.03.009 [doi]
AB  - The etiology of depression is characterized by the interplay of genetic and 
      environmental factors and brain structural alteration. Childhood adversity is a 
      major contributing factor in the development of depression. Interactions between 
      childhood adversity and candidate genes for depression could affect brain 
      morphology via the modulation of neurotrophic factors, serotonergic 
      neurotransmission, or the hypothalamus-pituitary-adrenal (HPA) axis, and this 
      pathway may explain the subsequent onset of depression. Childhood adversity is 
      associated with structural changes in the hippocampus, amygdala, anterior 
      cingulate cortex (ACC), and prefrontal cortex (PFC), as well as white matter 
      tracts such as the corpus callosum, cingulum, and uncinate fasciculus. Childhood 
      adversity showed an interaction with the brain-derived neurotrophic factor (BDNF) 
      gene Val66Met polymorphism, serotonin transporter-linked promoter region 
      (5-HTTLPR), and FK506 binding protein 51 (FKBP5) gene rs1360780 in brain 
      morphologic changes in patients with depression and in a non-clinical population. 
      Individuals with the Met allele of BDNF Val66Met and a history of childhood 
      adversity had reduced volume in the hippocampus and its subfields, amygdala, and 
      PFC and thinner rostral ACC in a study of depressed patients and healthy 
      controls. The S allele of 5-HTTLPR combined with exposure to childhood adversity 
      or a poorer parenting environment was associated with a smaller hippocampal 
      volume and subsequent onset of depression. The FKBP5 gene rs160780 had a 
      significant interaction with childhood adversity in the white matter integrity of 
      brain regions involved in emotion processing. This review identified that imaging 
      genetic studies on childhood adversity may deepen our understanding on the 
      neurobiological background of depression by scrutinizing complicated pathways of 
      genetic factors, early psychosocial environments, and the accompanying 
      morphologic changes in emotion-processing neural circuitry.
CI  - Copyright (c) 2018 Elsevier Inc. All rights reserved.
FAU - Kim, Yong-Ku
AU  - Kim YK
AD  - Department of Psychiatry, College of Medicine, Korea University, Seoul, Republic 
      of Korea.
FAU - Ham, Byung-Joo
AU  - Ham BJ
AD  - Department of Psychiatry, College of Medicine, Korea University, Seoul, Republic 
      of Korea.
FAU - Han, Kyu-Man
AU  - Han KM
AD  - Department of Psychiatry, College of Medicine, Korea University, Seoul, Republic 
      of Korea. Electronic address: drkyumanhan@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20180310
PL  - England
TA  - Prog Neuropsychopharmacol Biol Psychiatry
JT  - Progress in neuro-psychopharmacology & biological psychiatry
JID - 8211617
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (SLC6A4 protein, human)
RN  - 0 (Serotonin Plasma Membrane Transport Proteins)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - *Adverse Childhood Experiences/trends
MH  - Brain/*diagnostic imaging
MH  - Brain-Derived Neurotrophic Factor/genetics
MH  - Depression/*diagnostic imaging/*genetics
MH  - Genetic Variation/genetics
MH  - Humans
MH  - Polymorphism, Genetic/*genetics
MH  - Serotonin Plasma Membrane Transport Proteins/genetics
OTO - NOTNLM
OT  - 5-HTTLPR
OT  - BDNF Val66Met
OT  - Childhood adversity
OT  - Depression
OT  - FKBP5
OT  - Gene-environment interaction
OT  - Imaging genetics
EDAT- 2018/03/15 06:00
MHDA- 2019/04/16 06:00
CRDT- 2018/03/15 06:00
PHST- 2018/01/22 00:00 [received]
PHST- 2018/02/27 00:00 [revised]
PHST- 2018/03/09 00:00 [accepted]
PHST- 2018/03/15 06:00 [pubmed]
PHST- 2019/04/16 06:00 [medline]
PHST- 2018/03/15 06:00 [entrez]
AID - S0278-5846(18)30049-6 [pii]
AID - 10.1016/j.pnpbp.2018.03.009 [doi]
PST - ppublish
SO  - Prog Neuropsychopharmacol Biol Psychiatry. 2019 Apr 20;91:4-13. doi: 
      10.1016/j.pnpbp.2018.03.009. Epub 2018 Mar 10.