PMID- 29535092
OWN - NLM
STAT- MEDLINE
DCOM- 20180926
LR  - 20220408
IS  - 1757-790X (Electronic)
IS  - 1757-790X (Linking)
VI  - 2018
DP  - 2018 Mar 13
TI  - Ovarian teratoma associated with anti-NMDA (N-methyl D-aspartate) receptor 
      encephalitis.
LID - bcr-2017-220333 [pii]
LID - 10.1136/bcr-2017-220333 [doi]
LID - bcr2017220333
AB  - Anti-N-methyl D-aspartate receptor (NMDAR) encephalitis is a paraneoplastic, 
      immune-mediated encephalopathy with a known association with ovarian teratomas. 
      We present the first case in the UK of a 7-year-old patient presenting with this 
      condition. Having been previously fit and healthy, the patient presented with an 
      acute onset of cognitive disturbances. The initial suspicion was that of an 
      infective encephalopathy; however, the lumbar puncture results were negative. 
      Electroencephalography reported diffuse background slowing, supporting a 
      diagnosis of encephalopathy. Extensive autoimmune screening was done and found to 
      be positive for anti-NMDAR antibodies. A whole body MRI found a right adnexal 
      lesion consistent with ovarian teratoma. At laparoscopy, the right ovary was 
      excised and histology confirmed a mature cystic teratoma with neural tissue. 
      There were no postoperative complications with the patient's neurology recovering 
      progressively at follow-up.
CI  - (c) BMJ Publishing Group Ltd (unless otherwise stated in the text of the article) 
      2018. All rights reserved. No commercial use is permitted unless otherwise 
      expressly granted.
FAU - Leel, Nellihela
AU  - Leel N
AD  - Department of Paediatric Surgery, Guy's and St Thomas's NHS Foundation Trust, 
      London, UK.
FAU - Thakkar, Hemanshoo S
AU  - Thakkar HS
AD  - Department of Paediatric Surgery, Guy's and St Thomas's NHS Foundation Trust, 
      London, UK.
FAU - Drake, David
AU  - Drake D
AD  - Paediatric Surgery, Evelina Children's Hospital, London, UK.
FAU - Bouhadiba, Nordeen
AU  - Bouhadiba N
AD  - Department of Paediatric Surgery, Guy's and St Thomas's NHS Foundation Trust, 
      London, UK.
AD  - Evelina London Children's Hospital, Guy's and St Thomas NHS foundation Trust, 
      London, UK.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20180313
PL  - England
TA  - BMJ Case Rep
JT  - BMJ case reports
JID - 101526291
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - Teratoma, Ovarian
SB  - IM
MH  - Anti-N-Methyl-D-Aspartate Receptor 
      Encephalitis/*diagnosis/physiopathology/therapy
MH  - Child
MH  - Cognitive Dysfunction/diagnostic imaging/etiology
MH  - Dystonia/diagnostic imaging/etiology
MH  - Electroencephalography
MH  - Female
MH  - Humans
MH  - *Laparoscopy
MH  - Magnetic Resonance Imaging
MH  - Ovarian Neoplasms/*diagnosis/physiopathology/therapy
MH  - *Ovariectomy
MH  - Paraneoplastic Syndromes/*diagnosis/physiopathology/therapy
MH  - *Plasmapheresis
MH  - Receptors, N-Methyl-D-Aspartate/*immunology
MH  - Teratoma/*diagnosis/physiopathology/therapy
MH  - Treatment Outcome
PMC - PMC5878397
OTO - NOTNLM
OT  - neurology (drugs and medicines)
OT  - obstetrics, gynaecology and fertility
OT  - paediatric surgery
COIS- Competing interests: None declared.
EDAT- 2018/03/15 06:00
MHDA- 2018/09/27 06:00
PMCR- 2020/03/13
CRDT- 2018/03/15 06:00
PHST- 2018/03/15 06:00 [entrez]
PHST- 2018/03/15 06:00 [pubmed]
PHST- 2018/09/27 06:00 [medline]
PHST- 2020/03/13 00:00 [pmc-release]
AID - bcr-2017-220333 [pii]
AID - 10.1136/bcr-2017-220333 [doi]
PST - epublish
SO  - BMJ Case Rep. 2018 Mar 13;2018:bcr2017220333. doi: 10.1136/bcr-2017-220333.