PMID- 29535114
OWN - NLM
STAT- MEDLINE
DCOM- 20190709
LR  - 20200108
IS  - 1941-3297 (Electronic)
IS  - 1941-3289 (Print)
IS  - 1941-3289 (Linking)
VI  - 11
IP  - 3
DP  - 2018 Mar
TI  - Long-Term Caloric Restriction Improves Cardiac Function, Remodeling, Adrenergic 
      Responsiveness, and Sympathetic Innervation in a Model of Postischemic Heart 
      Failure.
PG  - e004153
LID - 10.1161/CIRCHEARTFAILURE.117.004153 [doi]
AB  - BACKGROUND: Caloric restriction (CR) has been described to have cardioprotective 
      effects and improve functional outcomes in animal models and humans. Chronic 
      ischemic heart failure (HF) is associated with reduced cardiac sympathetic 
      innervation, dysfunctional beta-adrenergic receptor signaling, and decreased cardiac 
      inotropic reserve. We tested the effects of a long-term CR diet, started late 
      after myocardial infarction on cardiac function, sympathetic innervation, and 
      beta-adrenergic receptor responsiveness in a rat model of postischemic HF. METHODS 
      AND RESULTS: Adult male rats were randomly assigned to myocardial infarction or 
      sham operation and 4 weeks later were further randomized to a 1-year CR or normal 
      diet. One year of CR resulted in a significant reduction in body weight, heart 
      weight, and heart weight/tibia length ratio when compared with normal diet in HF 
      groups. At the end of the study period, echocardiography and histology revealed 
      that HF animals under the CR diet had ameliorated left ventricular remodeling 
      compared with HF rats fed with normal diet. Invasive hemodynamic showed a 
      significant improvement of cardiac inotropic reserve in CR HF rats compared with 
      HF-normal diet animals. Importantly, CR dietary regimen was associated with a 
      significant increase of cardiac sympathetic innervation and with normalized 
      cardiac beta-adrenergic receptor levels in HF rats when compared with HF rats on the 
      standard diet. CONCLUSIONS: We demonstrate, for the first time, that chronic CR, 
      when started after HF established, can ameliorate cardiac dysfunction and improve 
      inotropic reserve. At the molecular level, we find that chronic CR diet 
      significantly improves sympathetic cardiac innervation and beta-adrenergic receptor 
      levels in failing myocardium.
CI  - (c) 2018 American Heart Association, Inc.
FAU - de Lucia, Claudio
AU  - de Lucia C
AD  - From the Division of Geriatrics, Department of Translational Medical Sciences, 
      Federico II University of Naples, Italy (C.d.L., G.G., L.P., A.E., K.K., G.D.F., 
      M.L.D., R.F., D. Liccardo, D. Leosco, N.F., G.R.); Center for Translational 
      Medicine (C.d.L., D. Liccardo, W.J.K.), Department of Pharmacology (C.d.L., D. 
      Liccardo, W.J.K.) and Cardiovascular Research Center (G.B., S.R.H.), Lewis Katz 
      School of Medicine, Temple University, Philadelphia, PA; Salvatore Maugeri 
      Foundation, IRCCS, Scientific Institute of Telese Terme (BN), Italy (G.G., A.E., 
      M.L.D., M.N., N.F., G.R.); and Neurology Imaging Unit, Imperial College London, 
      United Kingdom (G.D.F.).
FAU - Gambino, Giuseppina
AU  - Gambino G
AD  - From the Division of Geriatrics, Department of Translational Medical Sciences, 
      Federico II University of Naples, Italy (C.d.L., G.G., L.P., A.E., K.K., G.D.F., 
      M.L.D., R.F., D. Liccardo, D. Leosco, N.F., G.R.); Center for Translational 
      Medicine (C.d.L., D. Liccardo, W.J.K.), Department of Pharmacology (C.d.L., D. 
      Liccardo, W.J.K.) and Cardiovascular Research Center (G.B., S.R.H.), Lewis Katz 
      School of Medicine, Temple University, Philadelphia, PA; Salvatore Maugeri 
      Foundation, IRCCS, Scientific Institute of Telese Terme (BN), Italy (G.G., A.E., 
      M.L.D., M.N., N.F., G.R.); and Neurology Imaging Unit, Imperial College London, 
      United Kingdom (G.D.F.).
FAU - Petraglia, Laura
AU  - Petraglia L
AD  - From the Division of Geriatrics, Department of Translational Medical Sciences, 
      Federico II University of Naples, Italy (C.d.L., G.G., L.P., A.E., K.K., G.D.F., 
      M.L.D., R.F., D. Liccardo, D. Leosco, N.F., G.R.); Center for Translational 
      Medicine (C.d.L., D. Liccardo, W.J.K.), Department of Pharmacology (C.d.L., D. 
      Liccardo, W.J.K.) and Cardiovascular Research Center (G.B., S.R.H.), Lewis Katz 
      School of Medicine, Temple University, Philadelphia, PA; Salvatore Maugeri 
      Foundation, IRCCS, Scientific Institute of Telese Terme (BN), Italy (G.G., A.E., 
      M.L.D., M.N., N.F., G.R.); and Neurology Imaging Unit, Imperial College London, 
      United Kingdom (G.D.F.).
FAU - Elia, Andrea
AU  - Elia A
AD  - From the Division of Geriatrics, Department of Translational Medical Sciences, 
      Federico II University of Naples, Italy (C.d.L., G.G., L.P., A.E., K.K., G.D.F., 
      M.L.D., R.F., D. Liccardo, D. Leosco, N.F., G.R.); Center for Translational 
      Medicine (C.d.L., D. Liccardo, W.J.K.), Department of Pharmacology (C.d.L., D. 
      Liccardo, W.J.K.) and Cardiovascular Research Center (G.B., S.R.H.), Lewis Katz 
      School of Medicine, Temple University, Philadelphia, PA; Salvatore Maugeri 
      Foundation, IRCCS, Scientific Institute of Telese Terme (BN), Italy (G.G., A.E., 
      M.L.D., M.N., N.F., G.R.); and Neurology Imaging Unit, Imperial College London, 
      United Kingdom (G.D.F.).
FAU - Komici, Klara
AU  - Komici K
AD  - From the Division of Geriatrics, Department of Translational Medical Sciences, 
      Federico II University of Naples, Italy (C.d.L., G.G., L.P., A.E., K.K., G.D.F., 
      M.L.D., R.F., D. Liccardo, D. Leosco, N.F., G.R.); Center for Translational 
      Medicine (C.d.L., D. Liccardo, W.J.K.), Department of Pharmacology (C.d.L., D. 
      Liccardo, W.J.K.) and Cardiovascular Research Center (G.B., S.R.H.), Lewis Katz 
      School of Medicine, Temple University, Philadelphia, PA; Salvatore Maugeri 
      Foundation, IRCCS, Scientific Institute of Telese Terme (BN), Italy (G.G., A.E., 
      M.L.D., M.N., N.F., G.R.); and Neurology Imaging Unit, Imperial College London, 
      United Kingdom (G.D.F.).
FAU - Femminella, Grazia Daniela
AU  - Femminella GD
AD  - From the Division of Geriatrics, Department of Translational Medical Sciences, 
      Federico II University of Naples, Italy (C.d.L., G.G., L.P., A.E., K.K., G.D.F., 
      M.L.D., R.F., D. Liccardo, D. Leosco, N.F., G.R.); Center for Translational 
      Medicine (C.d.L., D. Liccardo, W.J.K.), Department of Pharmacology (C.d.L., D. 
      Liccardo, W.J.K.) and Cardiovascular Research Center (G.B., S.R.H.), Lewis Katz 
      School of Medicine, Temple University, Philadelphia, PA; Salvatore Maugeri 
      Foundation, IRCCS, Scientific Institute of Telese Terme (BN), Italy (G.G., A.E., 
      M.L.D., M.N., N.F., G.R.); and Neurology Imaging Unit, Imperial College London, 
      United Kingdom (G.D.F.).
FAU - D'Amico, Maria Loreta
AU  - D'Amico ML
AD  - From the Division of Geriatrics, Department of Translational Medical Sciences, 
      Federico II University of Naples, Italy (C.d.L., G.G., L.P., A.E., K.K., G.D.F., 
      M.L.D., R.F., D. Liccardo, D. Leosco, N.F., G.R.); Center for Translational 
      Medicine (C.d.L., D. Liccardo, W.J.K.), Department of Pharmacology (C.d.L., D. 
      Liccardo, W.J.K.) and Cardiovascular Research Center (G.B., S.R.H.), Lewis Katz 
      School of Medicine, Temple University, Philadelphia, PA; Salvatore Maugeri 
      Foundation, IRCCS, Scientific Institute of Telese Terme (BN), Italy (G.G., A.E., 
      M.L.D., M.N., N.F., G.R.); and Neurology Imaging Unit, Imperial College London, 
      United Kingdom (G.D.F.).
FAU - Formisano, Roberto
AU  - Formisano R
AD  - From the Division of Geriatrics, Department of Translational Medical Sciences, 
      Federico II University of Naples, Italy (C.d.L., G.G., L.P., A.E., K.K., G.D.F., 
      M.L.D., R.F., D. Liccardo, D. Leosco, N.F., G.R.); Center for Translational 
      Medicine (C.d.L., D. Liccardo, W.J.K.), Department of Pharmacology (C.d.L., D. 
      Liccardo, W.J.K.) and Cardiovascular Research Center (G.B., S.R.H.), Lewis Katz 
      School of Medicine, Temple University, Philadelphia, PA; Salvatore Maugeri 
      Foundation, IRCCS, Scientific Institute of Telese Terme (BN), Italy (G.G., A.E., 
      M.L.D., M.N., N.F., G.R.); and Neurology Imaging Unit, Imperial College London, 
      United Kingdom (G.D.F.).
FAU - Borghetti, Giulia
AU  - Borghetti G
AD  - From the Division of Geriatrics, Department of Translational Medical Sciences, 
      Federico II University of Naples, Italy (C.d.L., G.G., L.P., A.E., K.K., G.D.F., 
      M.L.D., R.F., D. Liccardo, D. Leosco, N.F., G.R.); Center for Translational 
      Medicine (C.d.L., D. Liccardo, W.J.K.), Department of Pharmacology (C.d.L., D. 
      Liccardo, W.J.K.) and Cardiovascular Research Center (G.B., S.R.H.), Lewis Katz 
      School of Medicine, Temple University, Philadelphia, PA; Salvatore Maugeri 
      Foundation, IRCCS, Scientific Institute of Telese Terme (BN), Italy (G.G., A.E., 
      M.L.D., M.N., N.F., G.R.); and Neurology Imaging Unit, Imperial College London, 
      United Kingdom (G.D.F.).
FAU - Liccardo, Daniela
AU  - Liccardo D
AD  - From the Division of Geriatrics, Department of Translational Medical Sciences, 
      Federico II University of Naples, Italy (C.d.L., G.G., L.P., A.E., K.K., G.D.F., 
      M.L.D., R.F., D. Liccardo, D. Leosco, N.F., G.R.); Center for Translational 
      Medicine (C.d.L., D. Liccardo, W.J.K.), Department of Pharmacology (C.d.L., D. 
      Liccardo, W.J.K.) and Cardiovascular Research Center (G.B., S.R.H.), Lewis Katz 
      School of Medicine, Temple University, Philadelphia, PA; Salvatore Maugeri 
      Foundation, IRCCS, Scientific Institute of Telese Terme (BN), Italy (G.G., A.E., 
      M.L.D., M.N., N.F., G.R.); and Neurology Imaging Unit, Imperial College London, 
      United Kingdom (G.D.F.).
FAU - Nolano, Maria
AU  - Nolano M
AD  - From the Division of Geriatrics, Department of Translational Medical Sciences, 
      Federico II University of Naples, Italy (C.d.L., G.G., L.P., A.E., K.K., G.D.F., 
      M.L.D., R.F., D. Liccardo, D. Leosco, N.F., G.R.); Center for Translational 
      Medicine (C.d.L., D. Liccardo, W.J.K.), Department of Pharmacology (C.d.L., D. 
      Liccardo, W.J.K.) and Cardiovascular Research Center (G.B., S.R.H.), Lewis Katz 
      School of Medicine, Temple University, Philadelphia, PA; Salvatore Maugeri 
      Foundation, IRCCS, Scientific Institute of Telese Terme (BN), Italy (G.G., A.E., 
      M.L.D., M.N., N.F., G.R.); and Neurology Imaging Unit, Imperial College London, 
      United Kingdom (G.D.F.).
FAU - Houser, Steven R
AU  - Houser SR
AD  - From the Division of Geriatrics, Department of Translational Medical Sciences, 
      Federico II University of Naples, Italy (C.d.L., G.G., L.P., A.E., K.K., G.D.F., 
      M.L.D., R.F., D. Liccardo, D. Leosco, N.F., G.R.); Center for Translational 
      Medicine (C.d.L., D. Liccardo, W.J.K.), Department of Pharmacology (C.d.L., D. 
      Liccardo, W.J.K.) and Cardiovascular Research Center (G.B., S.R.H.), Lewis Katz 
      School of Medicine, Temple University, Philadelphia, PA; Salvatore Maugeri 
      Foundation, IRCCS, Scientific Institute of Telese Terme (BN), Italy (G.G., A.E., 
      M.L.D., M.N., N.F., G.R.); and Neurology Imaging Unit, Imperial College London, 
      United Kingdom (G.D.F.).
FAU - Leosco, Dario
AU  - Leosco D
AD  - From the Division of Geriatrics, Department of Translational Medical Sciences, 
      Federico II University of Naples, Italy (C.d.L., G.G., L.P., A.E., K.K., G.D.F., 
      M.L.D., R.F., D. Liccardo, D. Leosco, N.F., G.R.); Center for Translational 
      Medicine (C.d.L., D. Liccardo, W.J.K.), Department of Pharmacology (C.d.L., D. 
      Liccardo, W.J.K.) and Cardiovascular Research Center (G.B., S.R.H.), Lewis Katz 
      School of Medicine, Temple University, Philadelphia, PA; Salvatore Maugeri 
      Foundation, IRCCS, Scientific Institute of Telese Terme (BN), Italy (G.G., A.E., 
      M.L.D., M.N., N.F., G.R.); and Neurology Imaging Unit, Imperial College London, 
      United Kingdom (G.D.F.).
FAU - Ferrara, Nicola
AU  - Ferrara N
AD  - From the Division of Geriatrics, Department of Translational Medical Sciences, 
      Federico II University of Naples, Italy (C.d.L., G.G., L.P., A.E., K.K., G.D.F., 
      M.L.D., R.F., D. Liccardo, D. Leosco, N.F., G.R.); Center for Translational 
      Medicine (C.d.L., D. Liccardo, W.J.K.), Department of Pharmacology (C.d.L., D. 
      Liccardo, W.J.K.) and Cardiovascular Research Center (G.B., S.R.H.), Lewis Katz 
      School of Medicine, Temple University, Philadelphia, PA; Salvatore Maugeri 
      Foundation, IRCCS, Scientific Institute of Telese Terme (BN), Italy (G.G., A.E., 
      M.L.D., M.N., N.F., G.R.); and Neurology Imaging Unit, Imperial College London, 
      United Kingdom (G.D.F.).
FAU - Koch, Walter J
AU  - Koch WJ
AD  - From the Division of Geriatrics, Department of Translational Medical Sciences, 
      Federico II University of Naples, Italy (C.d.L., G.G., L.P., A.E., K.K., G.D.F., 
      M.L.D., R.F., D. Liccardo, D. Leosco, N.F., G.R.); Center for Translational 
      Medicine (C.d.L., D. Liccardo, W.J.K.), Department of Pharmacology (C.d.L., D. 
      Liccardo, W.J.K.) and Cardiovascular Research Center (G.B., S.R.H.), Lewis Katz 
      School of Medicine, Temple University, Philadelphia, PA; Salvatore Maugeri 
      Foundation, IRCCS, Scientific Institute of Telese Terme (BN), Italy (G.G., A.E., 
      M.L.D., M.N., N.F., G.R.); and Neurology Imaging Unit, Imperial College London, 
      United Kingdom (G.D.F.). walter.koch@temple.edu giuseppe.rengo@unina.it.
FAU - Rengo, Giuseppe
AU  - Rengo G
AD  - From the Division of Geriatrics, Department of Translational Medical Sciences, 
      Federico II University of Naples, Italy (C.d.L., G.G., L.P., A.E., K.K., G.D.F., 
      M.L.D., R.F., D. Liccardo, D. Leosco, N.F., G.R.); Center for Translational 
      Medicine (C.d.L., D. Liccardo, W.J.K.), Department of Pharmacology (C.d.L., D. 
      Liccardo, W.J.K.) and Cardiovascular Research Center (G.B., S.R.H.), Lewis Katz 
      School of Medicine, Temple University, Philadelphia, PA; Salvatore Maugeri 
      Foundation, IRCCS, Scientific Institute of Telese Terme (BN), Italy (G.G., A.E., 
      M.L.D., M.N., N.F., G.R.); and Neurology Imaging Unit, Imperial College London, 
      United Kingdom (G.D.F.). walter.koch@temple.edu giuseppe.rengo@unina.it.
LA  - eng
GR  - P01 HL108806/HL/NHLBI NIH HHS/United States
GR  - P01 HL075443/HL/NHLBI NIH HHS/United States
GR  - R37 HL061690/HL/NHLBI NIH HHS/United States
GR  - P01 HL091799/HL/NHLBI NIH HHS/United States
GR  - R01 HL085503/HL/NHLBI NIH HHS/United States
GR  - R01 HL061690/HL/NHLBI NIH HHS/United States
GR  - R01 HL071818/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Circ Heart Fail
JT  - Circulation. Heart failure
JID - 101479941
RN  - 0 (Adrenergic Agents)
SB  - IM
CIN - Circ Heart Fail. 2018 Mar;11(3):e004930. PMID: 29535115
MH  - Adrenergic Agents
MH  - Animals
MH  - Caloric Restriction/methods
MH  - Disease Models, Animal
MH  - Heart/innervation
MH  - Heart Failure/*physiopathology
MH  - Hemodynamics/physiology
MH  - Male
MH  - Myocardial Contraction/physiology
MH  - Myocardial Infarction/*physiopathology
MH  - Rats, Sprague-Dawley
MH  - *Time
MH  - Ventricular Function, Left/physiology
MH  - Ventricular Remodeling/*physiology
PMC - PMC5858906
MID - NIHMS942966
OTO - NOTNLM
OT  - caloric restriction
OT  - heart failure
OT  - myocardial infarction
OT  - receptors, adrenergic
OT  - sympathetic nervous system
EDAT- 2018/03/15 06:00
MHDA- 2019/07/10 06:00
PMCR- 2019/03/01
CRDT- 2018/03/15 06:00
PHST- 2017/04/21 00:00 [received]
PHST- 2018/01/26 00:00 [accepted]
PHST- 2018/03/15 06:00 [entrez]
PHST- 2018/03/15 06:00 [pubmed]
PHST- 2019/07/10 06:00 [medline]
PHST- 2019/03/01 00:00 [pmc-release]
AID - CIRCHEARTFAILURE.117.004153 [pii]
AID - 10.1161/CIRCHEARTFAILURE.117.004153 [doi]
PST - ppublish
SO  - Circ Heart Fail. 2018 Mar;11(3):e004153. doi: 
      10.1161/CIRCHEARTFAILURE.117.004153.