PMID- 29535705
OWN - NLM
STAT- MEDLINE
DCOM- 20190307
LR  - 20190307
IS  - 1664-3224 (Print)
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 9
DP  - 2018
TI  - Immune-Mediated Inflammation Promotes Subclinical Atherosclerosis in Recent-Onset 
      Psoriatic Arthritis Patients without Conventional Cardiovascular Risk Factors.
PG  - 139
LID - 10.3389/fimmu.2018.00139 [doi]
LID - 139
AB  - Studies on the inflammatory burden in recent-onset psoriatic arthritis (PsA) 
      patients without conventional cardiovascular risk factors (CVRFs) are not 
      available. This preliminary study focuses on cardiovascular risk in cutaneous 
      psoriasis (CPs) and recent-onset PsA patients. Blood biochemistry (glucose, 
      cholesterol, uric acid, lipid profile and apolipoprotein B) was analyzed using 
      standard kits. Proatherogenic inflammation markers, C-reactive protein (CRP) and 
      interleukin-6 (IL-6), and endothelial activators monocyte chemoattractant 
      protein-1 (MCP-1) and soluble intercellular adhesion molecule-1 (sICAM-1), were 
      determined by enzyme-linked immunosorbent assay. Ultrasound images allowed 
      measuring carotid intima-media thickness (cIMT). Our study first shows an 
      increase in cIMT, and in serum levels of sICAM-1 and CRP in recent-onset PsA 
      patients not presenting conventional CVRFs over the non-medicated time-period, 
      from disease diagnosis to the beginning of pharmacological treatment, compared 
      with healthy subjects. The outcome highlights the importance of monitoring serum 
      level of sICAM1, CRP, and cIMT, and the value of primary prevention in psoriatic 
      patients even with no history of cardiovascular events.
FAU - Kolliker Frers, Rodolfo A
AU  - Kolliker Frers RA
AD  - Laboratorio de Citoarquitectura y Plasticidad Neuronal (LCPN), Instituto de 
      Investigaciones Cardiologicas, ININCA-UBA-CONICET, Buenos Aires, Argentina.
AD  - Unidad de Reumatologia, Hospital JM Ramos Mejia, Buenos Aires, Argentina.
FAU - Cosentino, Vanesa
AU  - Cosentino V
AD  - Unidad de Reumatologia, Hospital JM Ramos Mejia, Buenos Aires, Argentina.
FAU - Tau, Julia
AU  - Tau J
AD  - Laboratorio de Investigacion Ocular, Departamento de Patologia, Facultad de 
      Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina.
FAU - Kerzberg, Eduardo M
AU  - Kerzberg EM
AD  - Unidad de Reumatologia, Hospital JM Ramos Mejia, Buenos Aires, Argentina.
FAU - Urdapilleta, Adriana
AU  - Urdapilleta A
AD  - Departamento de Radiologia, Hospital JM Ramos Mejia, Buenos Aires, Argentina.
FAU - Chiocconi, Monica
AU  - Chiocconi M
AD  - Laboratorio de determinaciones hormonales, Seccion de metabolismo de lipidos e 
      hidratos de carbono, Division Endocrinologia, Departamento de Diagnostico y 
      Tratamiento, Hospital JM Ramos Mejia, Buenos Aires, Argentina.
FAU - Kogan, Nora
AU  - Kogan N
AD  - Seccion Psoriasis, Division Dermatologia, Departamento de Clinica, Hospital JM 
      Ramos Mejia, Buenos Aires, Argentina.
FAU - Otero-Losada, Matilde
AU  - Otero-Losada M
AD  - Laboratorio de HPLC, Instituto de Investigaciones Cardiologicas, University of 
      Buenos Aires, National Research Council, ININCA-UBA-CONICET, Buenos Aires, 
      Argentina.
FAU - Capani, Francisco
AU  - Capani F
AD  - Laboratorio de Citoarquitectura y Plasticidad Neuronal (LCPN), Instituto de 
      Investigaciones Cardiologicas, ININCA-UBA-CONICET, Buenos Aires, Argentina.
AD  - Departamento de Biologia, Universidad John F Kennedy, Buenos Aires, Argentina.
AD  - Universidad Autonoma de Chile, Santiago, Chile.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180226
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
RN  - 0 (Cytokines)
RN  - 0 (ICAM1 protein, human)
RN  - 126547-89-5 (Intercellular Adhesion Molecule-1)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Arthritis, Psoriatic/blood/diagnostic imaging/*immunology
MH  - Atherosclerosis/blood/diagnostic imaging/*immunology
MH  - C-Reactive Protein/analysis
MH  - Carotid Intima-Media Thickness
MH  - Cytokines/blood
MH  - Female
MH  - Humans
MH  - Intercellular Adhesion Molecule-1/blood
MH  - Male
MH  - Middle Aged
MH  - Risk Factors
MH  - Severity of Illness Index
PMC - PMC5834432
OTO - NOTNLM
OT  - C-reactive protein
OT  - IL-6
OT  - atherogenesis
OT  - atherosclerosis
OT  - carotid intima-media thickness
OT  - chronic inflammation
OT  - psoriatic arthritis
OT  - soluble intercellular adhesion molecule-1
EDAT- 2018/03/15 06:00
MHDA- 2018/03/15 06:01
PMCR- 2018/01/01
CRDT- 2018/03/15 06:00
PHST- 2017/08/23 00:00 [received]
PHST- 2018/01/16 00:00 [accepted]
PHST- 2018/03/15 06:00 [entrez]
PHST- 2018/03/15 06:00 [pubmed]
PHST- 2018/03/15 06:01 [medline]
PHST- 2018/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2018.00139 [doi]
PST - epublish
SO  - Front Immunol. 2018 Feb 26;9:139. doi: 10.3389/fimmu.2018.00139. eCollection 
      2018.