PMID- 29535726
OWN - NLM
STAT- MEDLINE
DCOM- 20190327
LR  - 20190327
IS  - 1664-3224 (Print)
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 9
DP  - 2018
TI  - Mechanisms of Tolerance Induction by Dendritic Cells In Vivo.
PG  - 350
LID - 10.3389/fimmu.2018.00350 [doi]
LID - 350
AB  - Dendritic cells (DCs) are a heterogeneous population playing a pivotal role in 
      immune responses and tolerance. DCs promote immune tolerance by participating in 
      the negative selection of autoreactive T cells in the thymus. Furthermore, to 
      eliminate autoreactive T cells that have escaped thymic deletion, DCs also induce 
      immune tolerance in the periphery through various mechanisms. Breakdown of these 
      functions leads to autoimmune diseases. Moreover, DCs play a critical role in 
      maintenance of homeostasis in body organs, especially the skin and intestine. In 
      this review, we focus on recent developments in our understanding of the 
      mechanisms of tolerance induction by DCs in the body.
FAU - Hasegawa, Hitoshi
AU  - Hasegawa H
AD  - Department of Hematology, Clinical Immunology and Infectious Diseases, Ehime 
      University Graduate School of Medicine, Toon, Japan.
FAU - Matsumoto, Takuya
AU  - Matsumoto T
AD  - Department of Hematology, Clinical Immunology and Infectious Diseases, Ehime 
      University Graduate School of Medicine, Toon, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20180226
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
SB  - IM
MH  - Animals
MH  - Dendritic Cells/cytology/*immunology
MH  - Humans
MH  - Immune Tolerance/*physiology
MH  - Intestines/cytology/*immunology
MH  - Skin/cytology/*immunology
MH  - T-Lymphocytes/cytology/*immunology
MH  - Thymus Gland/cytology/*immunology
PMC - PMC5834484
OTO - NOTNLM
OT  - dendritic cells
OT  - development
OT  - immune tolerance
OT  - intestine
OT  - regulatory T cells
OT  - skin
OT  - thymus
EDAT- 2018/03/15 06:00
MHDA- 2018/03/15 06:01
PMCR- 2018/01/01
CRDT- 2018/03/15 06:00
PHST- 2017/10/08 00:00 [received]
PHST- 2018/02/07 00:00 [accepted]
PHST- 2018/03/15 06:00 [entrez]
PHST- 2018/03/15 06:00 [pubmed]
PHST- 2018/03/15 06:01 [medline]
PHST- 2018/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2018.00350 [doi]
PST - epublish
SO  - Front Immunol. 2018 Feb 26;9:350. doi: 10.3389/fimmu.2018.00350. eCollection 
      2018.